Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris

Year 2018, , 65 - 73, 28.03.2018

Emin Özlü , Ragıp Ertaş Kemal Özyurt , İsmail Karaatlı , Ayşe Serap Karadağ

https://doi.org/10.18521/ktd.378682

Cited By: 2

Abstract

Objective: We
aimed to investigate the effect of isotretinoin treatment on sleep and quality
of life in patients with AV.

Methods: Sixty-six
AV patients, who had attended the dermatology outpatient clinic and started
isotretinoin treatment, and forty-three healthy controls, were enrolled in the
study. Pittsburg Sleep Quality Index (PSQI), short form-36 (SF-36), and Global
Acne Grading System (GAGS) were administered to all patients twice; before and
two months after the treatment. The results were compared with the healthy
control group.

Results: The
pretreatment physical health scores of the patients were significantly higher
than the healthy controls. No
significant differences were observed between before-after isotretinoin
treatment regarding physical and mental health scores in AV patients. While
there were no significant differences between the pretreatment and healthy
control group in terms of total PSQI scores; the scores of sleep duration were
significantly lower in the pretreatment group. No significant differences were
observed between before-after isotretinoin treatment regarding total PSQI and subcomponent
scores in AV patients. There was a statistically significant negative
correlation between pre- and post-treatment total PSQI scores and physical,
mental health scores in patients with AV.

Conclusion:
Results of the present study suggest that
isotretinoin therapy does not affect the sleep quality in patients with AV. The
impairment of sleep quality negatively affects the quality of life in patients
with AV. More comprehensive studies assessing the effect of isotretinoin
treatment on sleep quality are needed.

Keywords

Acne vulgaris, isotretinoin, sleep disorders, quality of life

Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi

Abstract

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