Malaria and Treatment

Abstract

Abstract

The number of people travelling to malaria-endemic countries continues to increase, and malaria remains the commonest cause of serious imported infection innonendemic areas. Severe malaria, mostly caused by Plasmodium falciparum, often requires intensive care unit (ICU) admission and can be complicated by cerebral malaria, respiratory distress, acute kidney injury, bleeding complications, and coinfection. This article reviews the manifestations, complications and principles of management of malaria.

Keywords

• Malaria,children,anti-malarial therapy.

Sıtma (Malarya) ve Tedavisi

Öz

Öz

Sıtma malaryanın endemik olduğu ülkelere seyahatler arttıkça önemli bir sağlık sorunu olarak karşımıza çıkmaktadır. Ciddi malarya Plasmodium falciparum’un neden olduğu, sıklıkla yoğun bakım yatışı gerektiren, serebral malarya, solunum sıkıntısı, akut böbrek yetersizliği, kanamalar ve koenfeksiyonlarla komplike olabilen bir tablodur. Bu yazıda sıtmanın klinik bulguları, komplikasyonları ve tedavi prensip-leri gözden geçirilmektedir.

Anahtar Kelimeler

• Sıtma,çocuk,antimalaryal tedavi

Kaynakça

1. Kaynaklar 1.World Health Organization. World Malaria Report 2012.WHO. Geneva, 2012. 2.Mali S, Kachur SP, Arguin PM. Malaria surveillance—Uni-ted States, 2009. MMWR Surveill Summ 2012; 61: 1. 3.Odolini S, Parola P, Gkrania-Klotsas E, et al. Travel-rela-ted imported infections in Europe, EuroTravNet 2009. ClinMicrobiol Infect 2012; 18: 468–74. 4.Leder K, Torresi J, Libman MD, et al. GeoSentinel surve-illance of illness in returned travelers, 2007–2011. Ann In-tern Med 2013; 158: 456–68. 5.Agarwal A, McMorrow M, Arguin PM. PlasmodiumSpe-cies (Malaria). In: Long SS, Pickering LK, Prober CG, eds.Principles and Practice of Pediatric Infectious Diseases, 4thed. New York: Saunders, 2012: 1298-306. 6.Warrell D, Gilles H. Essential Malariology, 4th Ed. Lon-don: Hodder Arnold, 2002. 7.Daneshvar C, Davis TME, Cox-Singh J, et al. Clinical andlaboratory features of human Plasmodiumknowlesi infec-tion. Clin Infect Dis 2009; 49: 852–60. 8.Roberts C, Armstrong M, Zatyka E. Gametocyte carria-ge in Plasmodiumfalciparum-infected travellers. Malar J2013; 12: 31. 9.Marks ME, Armstrong M, Suvari MM, et al. Severe im-ported falciparum malaria among adults requiring intensi-ve care: a retrospective study at the hospital for tropical di-seases, London. BMC Infect Dis 2013; 13: 118. 10.World Health Organization. Severe falciparum malaria.Trans R Soc Trop Med Hyg 2000; 94(Suppl.): 1–90. 11.Lalloo DG, Shingadia D, Pasvol G, et al. UK malaria tre-atment guidelines. J Infect 2007; 54: 111–21. 12.World Health Organization. Guidelines for the Treatmentof Malaria, 2nd ed. Geneva, 2011.