Öz
Abstract
The most common diseases in the world are upper respiratory tract infections, resulting in substantial morbidity, mortality, and financial loss. Viruses are reportedto be the most important pathogens involved. Several antiviral compounds have beendeveloped. Cystus052, a plant extract from a special variety of Cistus incanus that is rich in polymeric polyphenols, has been shown to exhibit antiviral activity. In thisarticle, the properties and efficacy of Cistus incanusis reviewed.
Anahtar Kelimeler
Cistus polyphenols upperrespiratory infections antiviral agents
Kaynakça
- Kaynaklar 1.Cos P, De Bruyne T, Hermans N, Apers S, Vanden Berghe D,Vlietinck AJ. Proanthocyanidins in health care: current andnew trends. Curr Med Chem 2004; 11: 1345–59. 2.Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shima-mura T. Inhibition of the infectivity of influenza virus by teapolyphenols. Antiviral Res 1993; 21: 289–99. 3.Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxi-dative stress. Biol Res 2000; 33: 55–64. 4.Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K, etal. A polyphenol rich plant extract, CYSTUS052, exerts antiinfluenza virus activity in cell culture without toxic side effectsor the tendency to induce viral resistance. Antiviral Res 2007;76: 38–47. 5.Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiesewet-tera H, Radtkea H. Cistus incanus (CYSTUS052) for treatingpatients with infection of the upper respiratory tract A pros-pective, randomised, placebo-controlled clinical study. Anti-viral Research 2009: 84; 267–71. 6.Ulrich Kalus, Holger Kiesewetter, Hartmut Radtke. Effect ofCYSTUS052 and green tea on subjective symptoms in patientswith infection of the upper respiratory tract. Phytother Res2010: 24; 96–100. 7.Kiesewetter H. Cystussud zur lokalen Behandlung der Ton-sillopharyngitis. Erfahrungsheilkunge 2002; 11: 792–93. 8.Rebensburg S, Helfer M, Schneider M, Herwig Koppenstei-ner H, Eberle J, et al. Potent in vitro antiviral activity of Cis-tus incanus extract against HIV and Filoviruses targets viralenvelope proteins. Scientific Reports 2016; Feb 2; 6: 20394.doi: 10.1038/srep20394. 9.Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, HannigM, Speer K, et al. The polyphenolic composition of Cistus in-canus herbal tea and its antibacterial and anti-adherent ac-tivity against Streptococcus mutans. Planta Med 2015; 81:1727-35. 10.Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mer-cenier A. Guidance for substantiating the evidence for benefi-cial effects of probiotics: prevention and management of aller-gic diseases by probiotics. J Nutr 2010; 140: 713–21. 11.Singh A, Holvoet S, Mercenier A. Dietary polyphenols in theprevention and treatment of allergic diseases. Clinical & Ex-perimental Allergy, 2011; 41: 1346–59.
Öz
Öz
Dünyada en yaygın hastalık olan üst solunum yolu enfeksiyonları (ÜSYE) yüksek morbidite, mortalite ve ekonomik kayıplara yol açmaktadır. ÜSYE etiyolojisinde en sık saptanan patojenler viruslardır. Korunma ve tedavi amaçlı birçok antiviral özellikte madde geliştirilmiştir. Cystus052, Cistus incanus bitkisinden elde edilen bir bitki özütü olup polimerik polifenollerden zengindir ve antiviral etkinliği gösterilmiştir. Bu yazıda Cistus incanus bitki özütünün özellikleri ve etkinliği değerlen-dirilmektedir.
Anahtar Kelimeler
Cistus polifenoller üst solunumyolu enfeksiyonları antiviralajanlar
Kaynakça
- Kaynaklar 1.Cos P, De Bruyne T, Hermans N, Apers S, Vanden Berghe D,Vlietinck AJ. Proanthocyanidins in health care: current andnew trends. Curr Med Chem 2004; 11: 1345–59. 2.Nakayama M, Suzuki K, Toda M, Okubo S, Hara Y, Shima-mura T. Inhibition of the infectivity of influenza virus by teapolyphenols. Antiviral Res 1993; 21: 289–99. 3.Urquiaga I, Leighton F. Plant polyphenol antioxidants and oxi-dative stress. Biol Res 2000; 33: 55–64. 4.Ehrhardt C, Hrincius, ER, Korte V, Mazur I, Droebner K, etal. A polyphenol rich plant extract, CYSTUS052, exerts antiinfluenza virus activity in cell culture without toxic side effectsor the tendency to induce viral resistance. Antiviral Res 2007;76: 38–47. 5.Kalusa U, Grigorova A, Kadeckib O, Jansenc JP, Kiesewet-tera H, Radtkea H. Cistus incanus (CYSTUS052) for treatingpatients with infection of the upper respiratory tract A pros-pective, randomised, placebo-controlled clinical study. Anti-viral Research 2009: 84; 267–71. 6.Ulrich Kalus, Holger Kiesewetter, Hartmut Radtke. Effect ofCYSTUS052 and green tea on subjective symptoms in patientswith infection of the upper respiratory tract. Phytother Res2010: 24; 96–100. 7.Kiesewetter H. Cystussud zur lokalen Behandlung der Ton-sillopharyngitis. Erfahrungsheilkunge 2002; 11: 792–93. 8.Rebensburg S, Helfer M, Schneider M, Herwig Koppenstei-ner H, Eberle J, et al. Potent in vitro antiviral activity of Cis-tus incanus extract against HIV and Filoviruses targets viralenvelope proteins. Scientific Reports 2016; Feb 2; 6: 20394.doi: 10.1038/srep20394. 9.Wittpahl G, Kölling-Speer I, Basche S, Herrmann E, HannigM, Speer K, et al. The polyphenolic composition of Cistus in-canus herbal tea and its antibacterial and anti-adherent ac-tivity against Streptococcus mutans. Planta Med 2015; 81:1727-35. 10.Kalliomaki M, Antoine JM, Herz U, Rijkers GT, Wells JM, Mer-cenier A. Guidance for substantiating the evidence for benefi-cial effects of probiotics: prevention and management of aller-gic diseases by probiotics. J Nutr 2010; 140: 713–21. 11.Singh A, Holvoet S, Mercenier A. Dietary polyphenols in theprevention and treatment of allergic diseases. Clinical & Ex-perimental Allergy, 2011; 41: 1346–59.
Ayrıntılar
| Birincil Dil | Türkçe |
|---|---|
| Bölüm | makale |
| Yazarlar | |
| Yayımlanma Tarihi | 15 Kasım 2018 |
| Yayımlandığı Sayı | Yıl 2018 Cilt: 10 Sayı: 6 |
