Çocukluk Çağında Hematopoetik Kök Hücre Nakli
Yıl 2019,
Cilt: 11 Sayı: 6, 273 - 279, 01.12.2019
Zeynep Karakaş
Tunç Fışgın
Öz
Hematopoietik kök hücre nakli malin ve malin olmayan hastalığı olan çocuklarda
iyileştirici bir tedavi yöntemi olarak kabul edilmektedir. İlk kemik iliği nakli 1957
yılında D Thomas tarafından yapılmıştır. HLA gruplarının tanımlanması ve kullanılmasından
sonra transplantasyon başarısı artmış ve daha yaygın kullanılmaya başlanmıştır.
Bugün hematolojik malignite, immün yetmezlik, hemoglobinopati, kemik iliği
yetmezlikleri ve doğuştan metabolizma hastalıklarında son tedavi modeli olarak
kullanılmaktadır.
Kaynakça
- 1. Sureda A, Bader P, Cesaro S, et al. Indications for allo- and
auto-SCT for haematological diseases, solid tumours and immune
- disorders: current practice in Europe, 2015. Bone Marrow
Transplant 2015; 50 (8): 1037-56.
- 2. Thomas ED, Lochte HL, Lu WC, et al. Intravenous infusion
of bone marrow in patients receiving radiation and chemotherapy.
N Engl J Med 1957; 257: 491-96.
- 3. Buckley RH, Lucas ZJ, Hattler BG, et al. Defective cellular
immunity associated with chronic mucocutaneous moniliasis
- and recurrent staphylococcal botryomycosis: immunological
reconstitution by allogeneic bone marrow. Clin Exp Immunol
1968; 3 (2): 153-69.
- 4. Bach FH, Albertini RJ, Joo P, et al. Bone marrow transplantation
in a patient with Wiskott-Aldrich syndrome. Lancet 1968; 2 (7583): 1364-66.
- 5. Grupp SA, Frangoul H, Wall D, Pulsipher MA, Levine JE,
Schultz KR. Use of G-CSF in matched sibling donor pediatric
- allogeneic transplantation: a consensus statement from the
Children’s Oncology Group (COG) Transplant Discipline Committee
- and Pediatric Blood and Marrow Transplant Consortium
(PBMTC) Executive Committee. Pediatr Blood Cancer 2006; 46 (4): 414-21.
- 6. Yesilipek MA, Hazar V, Küpesiz A, Kizilörs A, Uguz A, Yegin O.
Peripheral blood stem cell transplantation in children with betathalassemia.
Bone Marrow Transplant 2001; 28 (11): 1037-40.
- 7. Pulsipher MA, Levine JE, Hayashi RJ, et al. Safety and efficacy of
allogeneic PBSC collection in normal pediatric donors: the pediatric
- blood and marrow transplant consortium experience (PBMTC)
1996-2003. Bone Marrow Transplant 2005; 35 (4): 361-67.
- 8. Pulsipher MA, Nagler A, Iannone R, Nelson RM. Weighing the risks
of G-CSF administration, leukopheresis, and standard marrow harvest:
- ethical and safety considerations for normal pediatric hematopoietic
cell donors. Pediatr Blood Cancer 2006; 46 (4): 422-33.
- 9. Rocha V, Gluckman E. Eurocord-Netcord registry and European
Blood and Marrow Transplant group. Improving outcomes
- of cord blood transplantation: HLA matching, cell dose
and other graft- and transplantation-related factors. Br J Haematol
2009; 147 (2): 262-74.
- 10. Brunstein CG, Weisdorf DJ. Future of cord blood for oncology
uses. Bone Marrow Transplant 2009; (44): 699-707.
- 11. Kögler G, Critser P, Trapp T, Yoder M. Future of cord blood for
non-oncology uses. Bone Marrow Transplant 2009; (44): 683-97.
- 12. Yeşilipek MA. Çocuklarda hematopoetik kök hücre nakli. Türk
Ped Arş 2014; 49: 91-98.
- 13. Gratwohl A. Principals of conditioning. In: Apperly J, Carreras
E, Gluckman E Grawthol A, Masszi T, (eds). Hematopoetic
- Stem Cell Transplantation, The EBMT Handbook. European
School of Hematology, 2008: 128-44.
- 14. Kansoy S. Çocukluk çağı solid tümörlerinde HKH naklinin yeri.
9. Ulusal Kemik İliği Transplantasyonu ve Kök Hücre Tedavileri
Kongresi, 3-5 Mart 2016, Antalya, s: 32-34.
- 15.Majhail NS, Farnia SH, Carpenter PA, et al. Indications for autologous
and allogeneic hematopoietic cell transplantation: Guidelines
- from the American Society for Blood and Marrow Transplantation.
Biol Blood Marrow Transplant 2015; 21 (11): 1863-69.
- 16. Indications for HSCT in Children- UK Paediatric BMT Group
2015, UK Paediatric BMT Group HSCT Indications, 15 October 2015.
- 17. Sureda A, Bader P, Cesaro S, et al. Indications for allo- and
auto-SCT for haematological diseases, solid tumours and immune
disorders: current practice in Europe, 2015. Bone Marrow
Transplant 2015; 50 (8): 1037-56.
- 18. Nucci M, Andrade F, Vigorito A, et al. Infectious complications
in patients randomized to receive allogeneic bone marrow
or peripheral blood transplantation. Transpl Infect Dis
2003; 5: 167-73.
- 19. Eapen M, Horowitz MM, Klein JP, et al. Higher mortality after
allogeneic peripheral-blood transplantation compared with
bone marrow in children and adolescents: the Histocompatibility
- and Alternate Stem Cell Source Working Committee of
the International Bone Marrow Transplant Registry. J Clin Oncol
2004; 22: 4872-80.
- 20. Cutler C, Giri S, Jeyapalan S, Paniagua D, Viswanathan A, Antin
JH. Acute and chronic graft-versus-host disease after allogeneic
peripheral blood stem-cell and bone marrow transplantation:
a meta-analysis. J Clin Oncol 2001; 19: 3685-91.
- 21. Rizzo JD, Wingard JR, Tichelli A, et al. Recommended screening
and preventive practices for long-term survivors after haematopoietic
cell transplantation: joint recommendations of the
- European Group for Blood and Marrow Transplantation, Centre
for International, Blood and Marrow Transplant Research,
- and the American Society for Blood and Marrow Transplantation
(EBMT/CIBMTR/ASBMT). Bone Marrow Transplant 2006; 37: 249-61.
- 22. Cohen A, Békássy AN, Gaiero A, et al. Endocrinological late
complications after hematopoietic SCT in children. Bone Marrow
Transplant 2008; 41 (Suppl 2): S43-48.
- 23. Baker KS, DeFor TE, Burns LJ, Ramsay NK, Neglia JP, Robison
LL. New malignancies after blood or marrow stem-cell
transplantation in children and adults: incidence and risk factors.
J Clin Oncol 2003; 21: 1352-58.
- 24. Dietz AC, Duncan CN, Alter BP, et al. The Second Pediatric Blood
and Marrow Transplant Consortium International Consensus
Conference on Late Effects after Pediatric Hematopoietic
- Cell Transplantation (HCT): Defining the Unique Late Effects
of Children Undergoing HCT for Immune Deficiencies, Inherited
Marrow Failure Disorders, and Hemoglobinopathies. Biol
Blood Marrow Transplant 2016: S1083-8791 (16) 30396-2.
- Bu Makale Klinik Tıp Pediatri Dergisi’nin Cilt 8 Sayı 6 Kasım - Aralık 2016 saysından alınarak tıpkısının aynısı olarak
yayınlamıştır.