Besin Alerjilerinde Bileşene Dayalı Tanı Yöntemi
Yıl 2020,
Cilt: 12 Sayı: 2, 96 - 102, 01.04.2020
Sevgi Sipahi Çimen
Cevdet Özemir
Öz
Tüm dünyada sıklığı giderek artan besin alerjilerinin tanı ve takibine yönelik araştırmalar
çoğalmakta, yeni tanısal yöntemler geliştirilmektedir. Bileşene dayalı tanı
yöntemi, tanı aşamasında daha yüksek duyarlılığa sahip olması ile gerçek duyarlılığın
çapraz reaksiyondan ayrımında kullanılabileceği gibi hastaların takibinde tolerans
gelişimi ile ilgili öngörü sağlaması ve besin yükleme testi sırasında ortaya çıkabilecek
reaksiyonları öngörmesi nedeni ile besin alerjilerinde tanı ve takip amaçlı
kullanılması önerilen yeni tanısal testlerdendir. Bu derlemede sık görülen besin alerjilerinde
bileşene dayalı tanı yönteminin klinik kullanımı özetlenmiştir.
Kaynakça
- 1. Ozdemir C. Alerjide in vitro tanı yöntemleri. Astım Allerji Immünoloji.
2008;6:27-8.
- 2. Federly TJ, Jones BL, Dai H, Dinakar C. Interpretation of food
specific immunoglobulin E levels in the context of total IgE.
Ann Allergy Asthma Immunol. 2013;111:20-4.
- 3. Treudler R, Simon JC. Overview of component resolved diagnostics.
Curr Allergy Asthma Rep. 2013;13:110-7.
- 4. Gupta M, Cox A, Nowak-Wegrzyn A, Wang J. Diagnosis of Food
Allergy. Immunol Allergy Clin North Am. 2018;38:39-52.
- 5. Shreffler WG. Microarrayed recombinant allergens for diagnostic
testing. J Allergy Clin Immunol. 2011;127:843-9; quiz 50-1.
- 6. Besin Alerjisi Türk Ulusal Rehberi 2017. Asthma Allergy Immunol.
2017:1-81.
- 7. Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger
C, Hofmaier S, et al. EAACI Molecular Allergology User's
Guide. Pediatr Allergy Immunol. 2016;27 Suppl 23:1-250.
- 8. Kucukosmanoglu E, Yazi D, Yesil O, Akkoc T, Gezer M, Ozdemir
C, et al. Prevalence of immediate hypersensitivity reactions
- to cow's milk in infants based on skin prick test and questionnaire.
Allergol Immunopathol (Madr). 2008;36:254-8.
- 9. Fiocchi A, Schunemann HJ, Brozek J, Restani P, Beyer K, Troncone
R, et al. Diagnosis and Rationale for Action Against Cow's
- Milk Allergy (DRACMA): a summary report. J Allergy Clin
Immunol. 2010;126:1119-28 e12.
- 10. Sastre J. Molecular diagnosis in allergy. Clin Exp Allergy.
2010;40:1442-60.
- 11. Borres MP, Maruyama N, Sato S, Ebisawa M. Recent advances
in component resolved diagnosis in food allergy. Allergol Int. 2016;65:378-87.
- 12. Ito K, Futamura M, Moverare R, Tanaka A, Kawabe T, Sakamoto
T, et al. The usefulness of casein-specific IgE and IgG4 antibodies
in cow's milk allergic children. Clin Mol Allergy. 2012;10:1.
- 13. Ahrens B, Lopes de Oliveira LC, Grabenhenrich L, Schulz G,
Niggemann B, Wahn U, et al. Individual cow's milk allergens
- as prognostic markers for tolerance development? Clin Exp
Allergy. 2012;42:1630-7.
- 14. Martorell-Aragones A, Echeverria-Zudaire L, Alonso-Lebrero
E, Bone-Calvo J, Martin-Munoz MF, Nevot-Falco S, et al.
- Position document: IgE-mediated cow's milk allergy. Allergol
Immunopathol (Madr). 2015;43:507-26.
- 15. Boyano-Martinez T, Garcia-Ara C, Pedrosa M, Diaz-Pena
JM, Quirce S. Accidental allergic reactions in children allergic
- to cow's milk proteins. J Allergy Clin Immunol.
2009;123:883-8.
- 16. Nowak-Wegrzyn A, Muraro A. Cow’s milk allergy. EAACI Molecular
Allergology User’s guide2016. p. 157-65.
- 17. Nowak-Wegrzyn A, Bloom KA, Sicherer SH, Shreffler WG, Noone
S, Wanich N, et al. Tolerance to extensively heated milk in
- children with cow's milk allergy. J Allergy Clin Immunol.
2008;122:342-7, 7 e1-2.
- 18. Ford LS, Bloom KA, Nowak-Wegrzyn AH, Shreffler WG, Masilamani
M, Sampson HA. Basophil reactivity, wheal size, and
- immunoglobulin levels distinguish degrees of cow's milk tolerance.
J Allergy Clin Immunol. 2013;131:180-6 e1-3.
- 19. Caubet JC, Nowak-Wegrzyn A, Moshier E, Godbold J, Wang
J, Sampson HA. Utility of casein-specific IgE levels in predicting
- reactivity to baked milk. J Allergy Clin Immunol.
2013;131:222-4 e1-4.
- 20. Petersen TH, Mortz CG, Bindslev-Jensen C, Eller E. Cow's
milk allergic children-Can component-resolved diagnostics predict
- duration and severity? Pediatr Allergy Immunol.
2018;29:194-9.
- 21. Pajno GB, Fernandez-Rivas M, Arasi S, Roberts G, Akdis CA, Alvaro-
Lozano M, et al. EAACI Guidelines on allergen immunotherapy: IgE-mediated food allergy. Allergy. 2018;73:799-815.
- 22. Kuitunen M, Englund H, Remes S, Moverare R, Pelkonen A,
Borres MP, et al. High IgE levels to alpha-lactalbumin, betalactoglobulin
- and casein predict less successful cow's milk oral
immunotherapy. Allergy. 2015;70:955-62.
- 23. Mann K. The chicken egg white proteome. Proteomics.
2007;7:3558-68.
- 24. Andersen MB, Hall S, Dragsted LO. Identification of european
allergy patterns to the allergen families PR-10, LTP, and
- profilin from Rosaceae fruits. Clin Rev Allergy Immunol.
2011;41:4-19.
- 25. Bartnikas LM, Sheehan WJ, Tuttle KL, Petty CR, Schneider
LC, Phipatanakul W. Ovomucoid specific immunoglobulin E
- as a predictor of tolerance to cooked egg. Allergy Rhinol (Providence).
2015;6:198-204.
- 26. Saifi M, Swamy N, Crain M, Brown LS, Bird JA. Tolerance
of a high-protein baked-egg product in egg-allergic children.
Ann Allergy Asthma Immunol. 2016;116:415-9.
- 27. Miceli Sopo S, Greco M, Cuomo B, Bianchi A, Liotti L, Monaco
S, et al. Matrix effect on baked egg tolerance in children
- with IgE-mediated hen's egg allergy. Pediatr Allergy Immunol.
2016;27:465-70.
- 28. Calamelli E, Liotti L, Beghetti I, Piccinno V, Serra L, Bottau
P. Component-Resolved Diagnosis in Food Allergies. Medicina (Kaunas). 2019;55.
- 29. Alessandri C, Zennaro D, Scala E, Ferrara R, Bernardi ML,
Santoro M, et al. Ovomucoid (Gal d 1) specific IgE detected
- by microarray system predict tolerability to boiled hen's egg
and an increased risk to progress to multiple environmental allergen sensitisation. Clin Exp Allergy. 2012;42:441-50.
- 30. Ohtani K, Sato S, Syukuya A, Asaumi T, Ogura K, Koike Y, et
al. Natural history of immediate-type hen's egg allergy in Japanese
children. Allergol Int. 2016;65:153-7.
- 31. Ando H, Moverare R, Kondo Y, Tsuge I, Tanaka A, Borres MP,
et al. Utility of ovomucoid-specific IgE concentrations in predicting
- symptomatic egg allergy. J Allergy Clin Immunol.
2008;122:583-8.
- 32. Longo G, Berti I, Burks AW, Krauss B, Barbi E. IgE-mediated
food allergy in children. Lancet. 2013;382:1656-64.
- 33. Sapone A, Bai JC, Ciacci C, Dolinsek J, Green PH, Hadjivassiliou
M, et al. Spectrum of gluten-related disorders: consensus
- on new nomenclature and classification. BMC Med.
2012;10:13.
- 34. Savilahti EM, Rantanen V, Lin JS, Karinen S, Saarinen KM, Goldis
M, et al. Early recovery from cow's milk allergy is associated
- with decreasing IgE and increasing IgG4 binding to cow's
milk epitopes. J Allergy Clin Immunol. 2010;125:1315-21 e9.
- 35. Palosuo K, Varjonen E, Kekki OM, Klemola T, Kalkkinen N,
Alenius H, et al. Wheat omega-5 gliadin is a major allergen
- in children with immediate allergy to ingested wheat. J Allergy
Clin Immunol. 2001;108:634-8.
- 36. Makela MJ, Eriksson C, Kotaniemi-Syrjanen A, Palosuo K,
Marsh J, Borres M, et al. Wheat allergy in children - new tools for diagnostics. Clin Exp Allergy. 2014;44:1420-30.
- 37. Gomez-Casado C, Garrido-Arandia M, Pereira C, Catarino
M, Parro V, Armentia A, et al. Component-resolved diagnosis
- of wheat flour allergy in baker's asthma. J Allergy Clin Immunol.
2014;134:480-3.
- 38. Nilsson N, Sjolander S, Baar A, Berthold M, Pahr S, Vrtala
S, et al. Wheat allergy in children evaluated with challenge
- and IgE antibodies to wheat components. Pediatr Allergy Immunol.
2015;26:119-25.
- 39. Tatham AS, Shewry PR. Allergens to wheat and related cereals.
Clin Exp Allergy. 2008;38:1712-26.
- 40. Constantin C, Quirce S, Poorafshar M, Touraev A, Niggemann
B, Mari A, et al. Micro-arrayed wheat seed and grass pollen
- allergens for component-resolved diagnosis. Allergy.
2009;64:1030-7.
- 41. Ito K, Futamura M, Borres MP, Takaoka Y, Dahlstrom J, Sakamoto
T, et al. IgE antibodies to omega-5 gliadin associate
- with immediate symptoms on oral wheat challenge in Japanese
children. Allergy. 2008;63:1536-42.
- 42. Kotaniemi-Syrjanen A, Palosuo K, Jartti T, Kuitunen M, Pelkonen
AS, Makela MJ. The prognosis of wheat hypersensitivity in children. Pediatr Allergy Immunol. 2010;21:e421-8.
- 43. Holzhauser T, Wackermann O, Ballmer-Weber BK, Bindslev-
Jensen C, Scibilia J, Perono-Garoffo L, et al. Soybean
- (Glycine max) allergy in Europe: Gly m 5 (beta-conglycinin)
and Gly m 6 (glycinin) are potential diagnostic markers for
- severe allergic reactions to soy. J Allergy Clin Immunol.
2009;123:452-8.
- 44. Ebisawa M, Brostedt P, Sjolander S, Sato S, Borres MP, Ito
K. Gly m 2S albumin is a major allergen with a high diagnostic
- value in soybean-allergic children. J Allergy Clin Immunol.
2013;132:976-8 e1-5.
- 45. Kattan JD, Sampson HA. Clinical reactivity to soy is best identified
by component testing to Gly m 8. J Allergy Clin Immunol
Pract. 2015;3:970-2 e1.
- 46. Mittag D, Vieths S, Vogel L, Becker WM, Rihs HP, Helbling
A, et al. Soybean allergy in patients allergic to birch pollen:
- clinical investigation and molecular characterization of allergens.
J Allergy Clin Immunol. 2004;113:148-54.
- 47. Berneder M, Bublin M, Hoffmann-Sommergruber K, Hawranek
T, Lang R. Allergen chip diagnosis for soy-allergic patients:
- Gly m 4 as a marker for severe food-allergic reactions
to soy. Int Arch Allergy Immunol. 2013;161:229-33.
- 48. Kosma P, Sjolander S, Landgren E, Borres MP, Hedlin G. Severe
reactions after the intake of soy drink in birch pollen-allergic
- children sensitized to Gly m 4. Acta Paediatr.
2011;100:305-6.
- 49. Rona RJ, Keil T, Summers C, Gislason D, Zuidmeer L, Sodergren
E, et al. The prevalence of food allergy: a meta-analysis. J Allergy Clin Immunol. 2007;120:638-46.
- 50. Dang TD, Tang M, Choo S, Licciardi PV, Koplin JJ, Martin PE,
et al. Increasing the accuracy of peanut allergy diagnosis by using
Ara h 2. J Allergy Clin Immunol. 2012;129:1056-63.
- 51. Ballmer-Weber BK, Lidholm J, Fernandez-Rivas M, Seneviratne
S, Hanschmann KM, Vogel L, et al. IgE recognition patterns
- in peanut allergy are age dependent: perspectives of the
EuroPrevall study. Allergy. 2015;70:391-407.
- 52. Beyer K, Grabenhenrich L, Hartl M, Beder A, Kalb B, Ziegert
M, et al. Predictive values of component-specific IgE for
- the outcome of peanut and hazelnut food challenges in children.
Allergy. 2015;70:90-8.
- 53. Lieberman JA, Glaumann S, Batelson S, Borres MP, Sampson
HA, Nilsson C. The utility of peanut components in the diagnosis
- of IgE-mediated peanut allergy among distinct populations.
J Allergy Clin Immunol Pract. 2013;1:75-82.
- 54. Klemans RJ, van Os-Medendorp H, Blankestijn M, Bruijnzeel-
Koomen CA, Knol EF, Knulst AC. Diagnostic accuracy of
- specific IgE to components in diagnosing peanut allergy: a
systematic review. Clin Exp Allergy. 2015;45:720-30.
- 55. Asarnoj A, Nilsson C, Lidholm J, Glaumann S, Ostblom E, Hedlin
G, et al. Peanut component Ara h 8 sensitization and tolerance
to peanut. J Allergy Clin Immunol. 2012;130:468-72.
- 56. Sicherer SH, Wood RA. Advances in diagnosing peanut allergy.
J Allergy Clin Immunol Pract. 2013;1:1-13; quiz 4.
- 57. Krause S, Reese G, Randow S, Zennaro D, Quaratino D, Palazzo
P, et al. Lipid transfer protein (Ara h 9) as a new peanut
- allergen relevant for a Mediterranean allergic population.
J Allergy Clin Immunol. 2009;124:771-8 e5.
- 58. Kleine-Tebbe J, Beyer K, Ebisawa M. Peanut allergy. EAACI
Molecular Allergology User’s guide2016. p. 235-44.
- 59. Vickery BP, Scurlock AM, Kulis M, Steele PH, Kamilaris J,
Berglund JP, et al. Sustained unresponsiveness to peanut in
- subjects who have completed peanut oral immunotherapy. J
Allergy Clin Immunol. 2014;133:468-75.
- 60. McWilliam V, Koplin J, Lodge C, Tang M, Dharmage S, Allen
K. The Prevalence of Tree Nut Allergy: A Systematic Review. Curr Allergy Asthma Rep. 2015;15:54.
- 61. Kattan JD, Sicherer SH, Sampson HA. Clinical reactivity to
hazelnut may be better identified by component testing than
- traditional testing methods. J Allergy Clin Immunol Pract.
2014;2:633-4 e1.
- 62. Tuano KS, Davis CM. Utility of Component-Resolved Diagnostics
in Food Allergy. Curr Allergy Asthma Rep. 2015;15:32.
- 63. Inoue Y, Sato S, Takahashi K, Yanagida N, Yamamoto H, Shimizu
N, et al. Component-resolved diagnostics can be useful
for identifying hazelnut allergy in Japanese children. Allergol
Int. 2019.
- 64. Buyuktiryaki B, Cavkaytar O, Sahiner UM, Yilmaz EA, Yavuz
ST, Soyer O, et al. Cor a 14, Hazelnut-Specific IgE, and SPT
- as a Reliable Tool in Hazelnut Allergy Diagnosis in Eastern
Mediterranean Children. J Allergy Clin Immunol Pract.
2016;4:265-72 e3.
- 65. Knol E, Wickman M. Tree nut and seed allergy. EAACI Molecular
Allergology User’s guide2016. p. 246-54.
- 66. Imamura T, Kanagawa Y, Ebisawa M. A survey of patients with
self-reported severe food allergies in Japan. Pediatr Allergy
Immunol. 2008;19:270-4.
- 67. Lee J, Jeong K, Jeon SA, Lee S. Component resolved diagnosis
of walnut allergy in young children: Jug r 1 as a major walnut
allergen. Asian Pac J Allergy Immunol. 2019.
- 68. Ciprandi G, Pistorio A, Silvestri M, Rossi GA, Tosca MA. Walnut
anaphylaxis: the usefulness of molecular-based allergy diagnostics.
Immunol Lett. 2014;161:138-9.
- 69. Cabanillas B, Jappe U, Novak N. Allergy to Peanut, Soybean,
and Other Legumes: Recent Advances in Allergen Characterization,
- Stability to Processing and IgE Cross-Reactivity.
Mol Nutr Food Res. 2018;62.