Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review

Mazlum Çöpür; Sidar Çöpür

doi:10.35365/ctjpp.20.2.8

Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review

Öz

Risperidone is a second generation anti-psychotic drug that is commonly preferred in the treatment of schizophrenia, attention deficit hyperactivity disorder and bipolar disorders. Risperidone-associated hepatic adverse effects have long been investigated and continues to be unclear. In this review, our aim is to establish the possible hepatic adverse effects linked to risperidone treatment in children and adolescent in terms of severities and reversibility. We performed literature search via electronic databases (PubMed, Embase and the Cochrane Library) in August 2019. Risperidone treatment may lead to alterations in liver function test (LFT), mostly asymptomatic and reversible with the discontinuation or normalizes with time. Furthermore, there are few cases reporting risperidone-induced cholestatic hepatitis and immunoallergic hepatitis. Although exact mechanism of action of risperidone on liver remains unknown, there are growing evidences that link alterations of fatty acid biosynthesis to hepatic adverse effects. We recommend physicians to take basal LFT prior to risperidone treatment and monitor LFT during treatment. Additionally, physicians should be aware that most alterations at LFT associated with risperidone use are asymptomatic and reversible. However, more comprehensive studies investigating risperidone-associated hepatic adverse effects should be performed to reach a definitive outcome.

Anahtar Kelimeler

Risperidone,liver function tests,reversibility,antipsychotic agents,adverse effect

Kaynakça

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Ayrıntılar

Birincil Dil

İngilizce

Konular

Psikiyatri

Bölüm

Derleme

Yazarlar

Mazlum Çöpür Bu kişi benim
Türkiye

Sidar Çöpür Bu kişi benim
Türkiye

Yayımlanma Tarihi

4 Nisan 2020

Gönderilme Tarihi

27 Eylül 2019

Kabul Tarihi

10 Ocak 2020

Yayımlandığı Sayı

Yıl 2020 Cilt: 2 Sayı: 1

DOI

https://doi.org/10.35365/ctjpp.20.2.8

IZ

https://izlik.org/JA86NX64UD

Kaynak Göster

RIS / Bibtex

APA

Çöpür, M., & Çöpür, S. (2020). Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi, 2(1), 54-58. https://doi.org/10.35365/ctjpp.20.2.8

AMA

1.Çöpür M, Çöpür S. Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review. KTPP Dergisi. 2020;2(1):54-58. doi:10.35365/ctjpp.20.2.8

Chicago

Çöpür, Mazlum, ve Sidar Çöpür. 2020. “Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review”. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi 2 (1): 54-58. https://doi.org/10.35365/ctjpp.20.2.8.

EndNote

Çöpür M, Çöpür S (01 Nisan 2020) Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi 2 1 54–58.

IEEE

[1]M. Çöpür ve S. Çöpür, “Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review”, KTPP Dergisi, c. 2, sy 1, ss. 54–58, Nis. 2020, doi: 10.35365/ctjpp.20.2.8.

ISNAD

Çöpür, Mazlum - Çöpür, Sidar. “Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review”. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi 2/1 (01 Nisan 2020): 54-58. https://doi.org/10.35365/ctjpp.20.2.8.

JAMA

1.Çöpür M, Çöpür S. Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review. KTPP Dergisi. 2020;2:54–58.

MLA

Çöpür, Mazlum, ve Sidar Çöpür. “Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review”. Kıbrıs Türk Psikiyatri ve Psikoloji Dergisi, c. 2, sy 1, Nisan 2020, ss. 54-58, doi:10.35365/ctjpp.20.2.8.

Vancouver

1.Mazlum Çöpür, Sidar Çöpür. Risperidone and Hepatotoxicity in Children and Adolescent: A Literature Review. KTPP Dergisi. 01 Nisan 2020;2(1):54-8. doi:10.35365/ctjpp.20.2.8