VAGUS SİNİR STİMÜLASYONU: NON-İNVAZİV VE İNVAZİV YÖNTEMLERİN KLİNİK VE FİZYOLOJİK ETKİLERİ

Öz

Vagus sinir stimülasyonu (VSS), parasempatik sinir sistemi üzerinden merkezi ve periferik mekanizmaları modüle ederek nörolojik, psikiyatrik ve inflamatuvar hastalıklarda terapötik potansiyel sunar. Hem invaziv hem de non-invaziv yaklaşımlarla uygulanabilen VSS, inflamatuar yanıtları düzenleyerek sitokin düzeylerinde azalma sağlamakta ve otonom sinir sistemi dengesini iyileştirmektedir. Randomize kontrollü çalışmalar ve sistematik derlemeler, transkutanöz auriküler VSS’in (taVSS) kardiyovasküler fonksiyonlar, egzersiz kapasitesi, postoperatif ağrı ve depresyon semptomları üzerinde olumlu etkilerini göstermektedir. Bununla birlikte, uygulama parametrelerinin standardizasyonu ve uzun dönem güvenlilik verileri hâlen sınırlıdır. Bu derleme, VSS’in fizyolojik etkilerini, klinik uygulamalarını ve yan etkilerini kapsamlı biçimde ele alarak, tedavi stratejilerinin kişiselleştirilmesi ve multidisipliner yönetimin önemini vurgulamaktadır.

Anahtar Kelimeler

• Ağrı
• İnflamasyon
• Nöromodülasyon
• Transkutanöz Auriküler Vagus Stimülasyonu
• Vagus Sinir Stimülasyonu

Etik Beyan

Sayın hocam,çalışmamız derleme çalışması olduğundan etik kurul raporu alınmamıştır. Saygılarımla

VAGUS NERVE STIMULATION: CLINICAL AND PHYSIOLOGICAL EFFECTS OF NON-INVASIVE AND INVASIVE METHODS

Öz

Vagus nerve stimulation (VNS) offers therapeutic potential in neurological, psychiatric, and inflammatory disorders by modulating central and peripheral mechanisms through the parasympathetic nervous system. Applied via both invasive and non-invasive approaches, VNS regulates inflammatory responses by reducing cytokine levels and improving autonomic nervous system balance. Randomized controlled trials and systematic reviews have demonstrated that transcutaneous auricular VNS (taVNS) exerts positive effects on cardiovascular function, exercise capacity, postoperative pain, and depressive symptoms. However, standardization of stimulation parameters and long-term safety data remain limited. This review comprehensively discusses the physiological effects, clinical applications, and adverse effects of VNS, emphasizing the importance of personalized treatment strategies and multidisciplinary management.

Anahtar Kelimeler

• Pain
• Inflammation
• Neuromodulation
• Transcutaneous Auricular Vagus Nerve Stimulation
• Vagus Nerve Stimulation

Kaynakça

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