Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis

Halil İbrahim Gökçe

doi:10.24998/maeusabed.1944050

EN

Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis

Abstract

The aim of this study is to investigate kidney damage and dysfunction in cats with Feline Infectious Peritonitis (FIP). Feline infectious peritonitis is a highly contagious and fatal Coronavirus infection in cats. It causes lesions in various organs such as the brain, liver, kidneys, and eyes. Therefore, in this study, kidney damage and dysfunction in cats with FIP were investigated using renal biomarkers. Nested-PCR was used to identify Feline Coronavirus (FCoV) positive and negative cats. Twenty cats showing clinical symptoms of either the wet or dry form of FIP, and testing positive for FCoV, were considered to have FIP and used as the study group. Additionally, 10 clinically healthy and FCoV-negative cats were used as a control group. Serum (s) and urine (u) samples were collected from all cats, and concentrations of symmetric dimethylarginine (SDMA), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule 1 (KIM-1) were determined using cat-specific ELISA kits. In the study, sSDMA, sKIM-1, and uSDMA, uKIM-1, and uNGAL values were significantly higher in cats with FIP compared to healthy cats. High NGAL, KIM-1, and SDMA levels indicate that acute tubular damage develops in 65-75% and decreased glomerular filtration rate in 40-50% of cats with FIP, respectively. Furthermore, it reveals that SDMA, KIM-1, and NGAL are more sensitive than creatinine in the early diagnosis of kidney damage in cats with FIP.

Keywords

References

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Details

Primary Language

English

Subjects

Veterinary Medicine

Journal Section

Research Article

Authors

Halil İbrahim Gökçe ^*
0000-0002-4458-0671
Türkiye

Publication Date

October 20, 2026

Submission Date

May 4, 2026

Acceptance Date

September 17, 2026

Published in Issue

Year 2026 Number: 2026

DOI

https://doi.org/10.24998/maeusabed.1944050

IZ

https://izlik.org/JA66WF67PS

Cite

RIS / Bibtex

APA

Gökçe, H. İ. (2026). Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis. Mehmet Akif Ersoy University Journal of Health Sciences Institute, 2026. https://doi.org/10.24998/maeusabed.1944050

AMA

1.Gökçe Hİ. Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2026;(2026). doi:10.24998/maeusabed.1944050

Chicago

Gökçe, Halil İbrahim. 2026. “Determination of Renal Dysfunction in Cats With Feline Infectious Peritonitis”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, nos. 2026. https://doi.org/10.24998/maeusabed.1944050.

EndNote

Gökçe Hİ (October 20, 2026) Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis. Mehmet Akif Ersoy University Journal of Health Sciences Institute 2026

IEEE

[1]H. İ. Gökçe, “Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis”, Mehmet Akif Ersoy University Journal of Health Sciences Institute, no. 2026, Oct. 2026, doi: 10.24998/maeusabed.1944050.

ISNAD

Gökçe, Halil İbrahim. “Determination of Renal Dysfunction in Cats With Feline Infectious Peritonitis”. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2026 (October 20, 2026). https://doi.org/10.24998/maeusabed.1944050.

JAMA

1.Gökçe Hİ. Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2026. doi:10.24998/maeusabed.1944050.

MLA

Gökçe, Halil İbrahim. “Determination of Renal Dysfunction in Cats With Feline Infectious Peritonitis”. Mehmet Akif Ersoy University Journal of Health Sciences Institute, no. 2026, Oct. 2026, doi:10.24998/maeusabed.1944050.

Vancouver

1.Halil İbrahim Gökçe. Determination of Renal Dysfunction in Cats with Feline Infectious Peritonitis. Mehmet Akif Ersoy University Journal of Health Sciences Institute. 2026 Oct. 20;(2026). doi:10.24998/maeusabed.1944050

Templates

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📝 Title Page.docx

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Artificial intelligence (AI)

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Generative AI tools can not be listed as authors or share responsibility of the submitted manuscript.
If generative AI is used while preparing the manuscript, authors have the full responsibility of factual accuracy of the manuscript and they are responsible for any possible plagiarism.
If authors used a written, visual, or other type of generative AI-created content in the manuscript, this use should be acknowledged in the acknowledgments section with an explanation of the used methods.
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Title page

Title

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Authors and affiliations

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Example:

Isaac Newton¹

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Correspondence

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Acknowledgments

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Anonymised Manuscript

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Page Setup:

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Font: Aptos (default font for MS Word) or Calibri (Previous default font for MS Word) in 12 pt size for all text including heading, tables, captions, and references)

Language:

Manuscript must be in English and preferably in US English

Titles and headings:

Main title should be bold, in all capital letters and aligned middle
All headings and subheadings should be numbered, bold and each word capitalized (Just Like in This Example)

Main Text Structure and Formatting

Abstract should be 250 words or less

Introduction should be concise with no subheadings.

Structure should follow IMRaD guidelines (Introduction, Methods, Results, Discussion)

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Reference style should follow APA guidelines (https://apastyle.apa.org/)

Using a reference manager such as Mendeley, Zotero or Paperpile is highly encouraged to streamline this processes.

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Supplementary Materials

Data that are not central to the main text or cannot be included in the article due to size or format limitations (e.g., videos, raw data traces, PowerPoint presentations) can be uploaded as supplementary material during submission. These files will be displayed alongside the published article with a link.

Each supplementary material should be submitted as separate files

Each supplementary material should be listed in a separate file (docx or odt) labeled with their description

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Data sheets (word, excel documents or other open source alternatives)
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Images
Audio files (mp3, wav, wma)
Video files (avi, flv, mov, mp4, mpg)

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The Mehmet Akif Ersoy University Journal of Health Sciences Institute uses the Creative Commons Attribution License (CC BY) for all published articles. This means authors keep their copyright but allow us to publish their work. We collaborate with authors to ensure accurate attribution and citation, enabling readers to freely share, adapt, and build upon the articles with proper acknowledgment. Our use of the CC BY license reflects our commitment to open access and open science, fostering collaboration and knowledge sharing within the scientific community. This ensures free access to our articles and promotes the advancement of research.

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Originality, high scientific quality, and citation potential are the most important criteria for a manuscript to be accepted for publication. Manuscripts submitted for evaluation should not have been previously presented or already published in an electronic or printed medium. The journal should be informed of manuscripts that have been submitted to another journal for evaluation and rejected for publication. Manuscripts that have been presented in a meeting should be submitted with detailed information on the organization, including the name, date, and location of the organization.

On receipt of the paper by the Editorial Board, the paper is evaluated for compliance with the format rules and the authors are informed about the result in four weeks. In the event that the paper is not found to comply with the general publication principles of the journal from the standpoint of either technical characteristics or general scope, the paper is rejected. Alternatively, the author(s) may be asked to re-submit the paper in accordance with the writing requirements. Papers resubmitted are passed through a similar technical examination and, if found to comply with the rules, are passed on for peer review. The paper is sent to two reviewers selected by the board without the title-page to maintain anonymity of the applicants. Reviewers then assess the paper for scientific content and format compliance. When necessary the Editorial Advisory Board can send the paper to third reviewers. The selection of reviewers is ultimately at the discretion of the editor, associate Editors and/or the editorial board. The appropriate reviewers can be selected from journal’s international database of reviewers listing or, if needed; independent reviewers can be determined from inland or abroad. Thereafter the Editorial Advisory Board carries out the final editing, taking the reports of the reviewers into consideration, and, when necessary, communicating with the author(s).

The Editorial Board assumes that the author(s) are obliged not to submit the paper to another journal before completion of the assessment process. The authors should inform the editorial board if they decide to withdraw the manuscript. The editor may consult editorial executive board about a manuscript if they deem necessary.

Compliance with the Helsinki Declaration Principles is mandatory in all clinical studies (http://www.wma.net/en/30publications/10policies/b3/index.html).
In such studies, the authors are expected to state that they conducted the study in the method section in accordance with the principles and that ethical councils and other persons participating in the study received an "informed consent form".
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Our journal does not publish special issues.

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Authors are required to disclose any existing or potential conflicts of interests, including financial, consultant, and institutional, that might lead to potential bias or a conflict of interest. Any financial grants or other support received for a submitted study from individuals or institutions should be disclosed to the Editorial Board. Cases of a potential conflict of interest of the editors, authors, or reviewers are resolved by the journal’s Editorial Board within the scope of COPE and ICMJE guidelines.

The Editorial Board of the journal handles all appeal and complaint cases within the scope of COPE guidelines. In such cases, authors should get in direct contact with the editorial office regarding their appeals and complaints. The Editor in Chief is the final authority in the decision-making process for all appeals and complaints.

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Publication in this journal is free. There are no publication charges, no submission charges, no article processing charges and no surcharges based on the length of an article, figures or supplementary data. Editorial items (Editorials, Corrections, Additions, Retractions, Letters, Comments, etc.) are published free of charge.

Plagiarism policy

Manuscripts submitted to Mehmet Akif Ersoy University Journal of Health Sciences Institute is evaluated in terms of plagiarism using iThenticate by CrossCheck. Even if you are the author of the phrases or sentences, the text should not have an unacceptable similarity with the previously published data. When you are discussing others' (or your own) previous work, please make sure that you cite the material correctly in every instance.

In the event of alleged or suspected research misconduct, e.g., plagiarism, citation manipulation, and data falsification or fabrication, the Editorial Board will follow and act in accordance with COPE guidelines (https://publicationethics.org/guidance/Guidelines).

Ethical responsibility

The Mehmet Akif Ersoy University Journal of Health Sciences Institute upholds the highest standards of impartiality, respect, and scientific integrity throughout its publication process. Dedicated to the accurate dissemination of knowledge and the advancement of science, the journal expects all participants (authors, reviewers, editors, and advisory board members) to adhere to ethical guidelines. These ethical duties and responsibilities are aligned with the recommendations and policies of the Committee on Publication Ethics (COPE). It an be accesses with this link: https://publicationethics.org/guidance/Guidelines

Responsibility of Authors

The authors are responsible for their compliance with the ethical rules. In experimental studies on animals or humans, it should be noted that the study protocol has been approved by the appropriate experiment ethics committee at the institution where the study was conducted. Authors should submit the ethics committee's approval with the article. If there are previously published text, tables, pictures, etc. in the article, the authors have to get written permission from the copyright holder and the authors should specify and indicate the used material in the manuscript. In the course of the manuscript evaluation, the authors may be requested to submit the research data and / or the ethics committee approval document if deemed necessary.

Responsibility of Section Editors

The final content of the journal must align with its stated aims and scope. A critical aspect of publication is maintaining integrity and objectivity, adhering to established industry standards. This includes selecting expert reviewers in the specific manuscript area to ensure rigorous evaluation. All editorial activities should be conducted in accordance with the COPE short guide to ethical editing, available at https://publicationethics.org/files/A_Short_Guide_to_Ethical_Editing.pdf.

Responsibility of Reviewers

Reviewers play a crucial role in scholarly publishing. Their responsibilities to authors include providing timely, unbiased, and constructive feedback on the work's merits, clarity, conciseness, scientific accuracy, originality, and relevance, while avoiding personal criticism and maintaining confidentiality. Toward editors, reviewers must promptly communicate their availability, disclose any conflicts of interest, adhere to review guidelines, and provide a thorough, fair, and informative critique. This critique should assess the work's scientific merit, originality, and scope, suggest improvements, and, if requested, recommend acceptance or rejection. Reviewers should also identify any ethical concerns, such as violations of research ethics or plagiarism, and refrain from direct contact with the authors.