Yıl 2018, Cilt 30 , Sayı 1, Sayfalar 94 - 104 2018-03-31

Recent Applications in Inhibition of Notch Signalling Pathway on Breast Cancer Stem Cell
Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar

Selcen ARI [1]


In the world, breast cancer is at the top of the list in deaths due to cancer in women. Although treatments such as chemotherapy, radiotherapy, hormonal therapy are used for the treatment of breast cancer, metastasis and recurrence are frequent cases. The most striking factor in the inability to effectively breast cancer treatment is cancer stem cells, which form a small population of tumor tissue. Studies on the elimination of breast cancer stem cells involve approaches that may be effective on developmental signaling pathways that play a critical role in the forming of stem cell characteristics. One of the most important developmental signaling pathways, the Notch signaling pathway is highly effective on apoptosis, proliferation, angiogenesis and differentiation mechanisms in breast cancer stem cells. Recent studies indicate that inhibition of the Notch signaling pathway, which plays a critical role in the characterization of cancer stem cells, is important for effective treatment approaches. In this review, different approaches will be discussed for inhibition of Notch signalling pathway in breast cancer treatment and methods that may be useful for efficient cancer treatment.

Dünyada kadınlarda kanser sebepli ölümlerde meme kanseri en üst sıralarda yer almaktadır. Kemoterapi, radyoterapi, hormonal tedavi gibi yöntemler meme kanserinin tedavisi için kullanılmasına rağmen metastaz ve nüks sıkça karşılaşılan durumlardır. Meme kanseri tedavisinin etkin olarak sağlanamamasında en çarpıcı etken tümör dokusundaki ufak bir popülasyonu oluşturan kanser kök hücreleridir. Meme kanser kök hücrelerinin eliminasyonu konusundaki çalışmalar kök hücre özelliklerinin ortaya çıkmasında kritik rol oynayan gelişimsel sinyal yolakları üzerinde etkili olabilecek yaklaşımları içermektedir. Gelişimsel sinyal yolaklarından en önemlilerinden biri olan Notch sinyal yolağı meme kanser kök hücrelerinde apoptoz, proliferasyon, anjiyojenez ve farklılaşma mekanizmaları üzerinde oldukça etkilidir. Güncel çalışmalar kanser kök hücrelerinin karakteristiğinde kritik rol oynayan Notch sinyal yolağının inhibisyonun etkili tedavi yaklaşımları için önemli olduğunu göstermektedir. Bu derlemede meme kanserinin tedavisinde Notch sinyal yolağının inhibisyonu için getirilmiş farklı yaklaşımlar ele alınacak ve gelecekte etkin kanser tedavisinin geliştirilmesinde faydalı olabilecek yöntemler tartışılacaktır.

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Birincil Dil tr
Konular Mühendislik
Bölüm Derleme
Yazarlar

Orcid: orcid.org/0000-0002-0028-2453
Yazar: Selcen ARI (Sorumlu Yazar)
Kurum: ALANYA ALAADDİN KEYKUBAT ÜNİVERSİTESİ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Mart 2018

Bibtex @derleme { marufbd336015, journal = {Marmara Fen Bilimleri Dergisi}, issn = {}, eissn = {2146-5150}, address = {}, publisher = {Marmara Üniversitesi}, year = {2018}, volume = {30}, pages = {94 - 104}, doi = {10.7240/marufbd.336015}, title = {Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar}, key = {cite}, author = {ARI, Selcen} }
APA ARI, S . (2018). Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar. Marmara Fen Bilimleri Dergisi , 30 (1) , 94-104 . DOI: 10.7240/marufbd.336015
MLA ARI, S . "Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar". Marmara Fen Bilimleri Dergisi 30 (2018 ): 94-104 <https://dergipark.org.tr/tr/pub/marufbd/issue/36224/336015>
Chicago ARI, S . "Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar". Marmara Fen Bilimleri Dergisi 30 (2018 ): 94-104
RIS TY - JOUR T1 - Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar AU - Selcen ARI Y1 - 2018 PY - 2018 N1 - doi: 10.7240/marufbd.336015 DO - 10.7240/marufbd.336015 T2 - Marmara Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 94 EP - 104 VL - 30 IS - 1 SN - -2146-5150 M3 - doi: 10.7240/marufbd.336015 UR - https://doi.org/10.7240/marufbd.336015 Y2 - 2018 ER -
EndNote %0 Marmara Fen Bilimleri Dergisi Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar %A Selcen ARI %T Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar %D 2018 %J Marmara Fen Bilimleri Dergisi %P -2146-5150 %V 30 %N 1 %R doi: 10.7240/marufbd.336015 %U 10.7240/marufbd.336015
ISNAD ARI, Selcen . "Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar". Marmara Fen Bilimleri Dergisi 30 / 1 (Mart 2018): 94-104 . https://doi.org/10.7240/marufbd.336015
AMA ARI S . Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar. MFBD. 2018; 30(1): 94-104.
Vancouver ARI S . Meme Kanser Kök Hücrelerinde Notch Sinyal Yolağının İnhibisyonunda Güncel Yaklaşımlar. Marmara Fen Bilimleri Dergisi. 2018; 30(1): 104-94.