Yıl 2018, Cilt 30 , Sayı 4, Sayfalar 403 - 414 2018-12-31

HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması

Asuman BUNSUZ [1] , Onur SERÇİNOĞLU [2] , Pemra ÖZBEK [3]


Hücre yüzey glikoproteinleri olan Temel Doku Uygunluk Kompleks (MHC) molekülleri yabancı antijenlere bağlanır ve onları uygun immün tanınma için antijen sunucu hücrelerin yüzeyindeki T lenfosit hücrelerine sunar. İlk olarak insanlarda lökosit hücrelerinde tanımlanmış oldukları için, aynı zamanda İnsan Lökosit Antijenleri (HLA) olarak da isimlendirilirler. Son zamanlarda peptit bazlı aşıların tasarlanması üzerine odaklanan çalışmalar, peptitin sitotoksik T hücre aracılı immün cevabı uyarma yeteneği olarak tanımlanan peptit immunojenite mekanizmasının anlaşılmasına olanak sağlamaktadır. Peptit immünojenisitesinin, peptit-HLA kompleksinin stabilitesi ile ilişkili olduğu bilinmektedir. Bu çalışmada, AIFQSSMTK and QVPLRPMTYK peptitlerine bağlanan HLA-A*03:01 ve HLA-A*11:01 alellerinin stabilitesinin temel moleküler mekanizmalarını ortaya çıkarmak için moleküler dinamik simülasyonları gerçekleştirilmiştir ve ENCOM sunucusu kullanılarak peptit rezidüleri üzerinde gerçekleştirilen tek nokta mutasyonlarının protein termostabilitesine olan tahmini etkisi araştırılmıştır. 

MHC Molekülü, Stabilite, Moleküler Dinamik Simülasyonu, Mutasyon, ENCOM
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Birincil Dil tr
Konular Mühendislik
Bölüm Araştırma Makaleleri
Yazarlar

Yazar: Asuman BUNSUZ

Yazar: Onur SERÇİNOĞLU

Yazar: Pemra ÖZBEK (Sorumlu Yazar)
Kurum: MARMARA ÜNİVERSİTESİ, MÜHENDİSLİK FAKÜLTESİ, BİYOMÜHENDİSLİK BÖLÜMÜ
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 31 Aralık 2018

Bibtex @araştırma makalesi { marufbd368789, journal = {Marmara Fen Bilimleri Dergisi}, issn = {}, eissn = {2146-5150}, address = {}, publisher = {Marmara Üniversitesi}, year = {2018}, volume = {30}, pages = {403 - 414}, doi = {10.7240/marufbd.368789}, title = {HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması}, key = {cite}, author = {BUNSUZ, Asuman and SERÇİNOĞLU, Onur and ÖZBEK, Pemra} }
APA BUNSUZ, A , SERÇİNOĞLU, O , ÖZBEK, P . (2018). HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması. Marmara Fen Bilimleri Dergisi , 30 (4) , 403-414 . DOI: 10.7240/marufbd.368789
MLA BUNSUZ, A , SERÇİNOĞLU, O , ÖZBEK, P . "HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması". Marmara Fen Bilimleri Dergisi 30 (2018 ): 403-414 <https://dergipark.org.tr/tr/pub/marufbd/issue/40256/368789>
Chicago BUNSUZ, A , SERÇİNOĞLU, O , ÖZBEK, P . "HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması". Marmara Fen Bilimleri Dergisi 30 (2018 ): 403-414
RIS TY - JOUR T1 - HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması AU - Asuman BUNSUZ , Onur SERÇİNOĞLU , Pemra ÖZBEK Y1 - 2018 PY - 2018 N1 - doi: 10.7240/marufbd.368789 DO - 10.7240/marufbd.368789 T2 - Marmara Fen Bilimleri Dergisi JF - Journal JO - JOR SP - 403 EP - 414 VL - 30 IS - 4 SN - -2146-5150 M3 - doi: 10.7240/marufbd.368789 UR - https://doi.org/10.7240/marufbd.368789 Y2 - 2018 ER -
EndNote %0 Marmara Fen Bilimleri Dergisi HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması %A Asuman BUNSUZ , Onur SERÇİNOĞLU , Pemra ÖZBEK %T HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması %D 2018 %J Marmara Fen Bilimleri Dergisi %P -2146-5150 %V 30 %N 4 %R doi: 10.7240/marufbd.368789 %U 10.7240/marufbd.368789
ISNAD BUNSUZ, Asuman , SERÇİNOĞLU, Onur , ÖZBEK, Pemra . "HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması". Marmara Fen Bilimleri Dergisi 30 / 4 (Aralık 2019): 403-414 . https://doi.org/10.7240/marufbd.368789
AMA BUNSUZ A , SERÇİNOĞLU O , ÖZBEK P . HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması. MFBD. 2018; 30(4): 403-414.
Vancouver BUNSUZ A , SERÇİNOĞLU O , ÖZBEK P . HLA Moleküllerinde Peptit Ligandlarının Kompleks Stabilitesine Olan Etkisinin Araştırılması. Marmara Fen Bilimleri Dergisi. 2018; 30(4): 414-403.