The effects of various hormone replacement therapy regimens on bone mineral density after 2 years of treatment

Yıl 1996, Cilt: 9 Sayı: 4, 165 - 168, 01.10.1996

H. Çelikkanat P. Moröy S. Şenöz í. Çetindağ O. Gökmen

Öz

Objective: The effects of various hormone replacement therapies on bone mineral density after 2 years of treatment were evaluated in this study.

Methods: A total of 138 patients treated with either conjugated equine estrogen or transdermal 17-(3 estradiol alone or in combination with medroxyprogesterone acetate or dydrogesterone had bone mineral density measurements of the first four lumbar vertebrae by using a Dual X-ray Hologic 1000 quantitative digital radiography densitometer.

Results: After 2 years of treatment, a significant increase in spinal bone mineral density was found in all groups. No significant differences were found among 6 treatment groups.

Conclusion: There were no differences between estrogen replacement therapies and combined hormone replacement therapies. Progesterone did not have any additional effect on bone mineral density.

Anahtar Kelimeler

Menopause, Osteoporosis, Bone mineral density, Hormone replacement therapy, Conjugated equine estrogen, Transdermal estradiol, Dydrogesterone, Medroxyprogesterone acetate

Kaynakça

• Lindsay H, Hart DM, Aitken JM, Mac Donald EB, Anderson JB, Clarke AC. Longterm prevention of postmenopausal osteoporosis by oestrogen. Evidence for an increased bone mass after delayed onset of oestrogen treatment Lancet 1976:1 (7968); 1038-1041.