Yıl 1998, Cilt 11 , Sayı 3, Sayfalar 152 - 155 1998-07-01

The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis

S. Şimşek [1] , P. Göktaş [2] , D. COŞKUN [3]


Objective: To determine the in vitro activity and place of fluoroquinolones in combination therapy of brucellosis and to compare these results with the results of doxycycline plus rifampicin combination which is the current regimen of therapy.

Method: Eight blood isolates of Brucella melitensis were used. Minimal inhibitory concentration (MIC) values of doxycycline, rifampicin, ofloxacin and ciprofloxacin were determined by agar dilution method and the effect of combination was tested by simplified checkerboard method.

Results: The MIC values for doxycycline, rifampicin, ofloxacin and ciprofloxacin were found as 1.0, 4.0, 0.5 and 1.0 pg/ml respectively. The effect of combination of ofloxacin with doxycycline or rifampicin was found to be indifferent, when combinations of ciprofloxacin with doxycycline or rifampicin and doxycycline with rifampicin were additive.

Conclusion: These results may encourage clinical use of a fluoroquinolone in the combination therapy of brucellosis.

Brucella melitensis, in vitro susceptibility
  • Young EJ. Brucella species. In: Man del I GL, Bennett JE, Dolin R, eds. Principles and practice of infectious diseases, 4th ed, Vol 2. Hewyork: Churchill Livingstone Inc, 1995:2053-2060.
Konular Tıp
Bölüm Derleme
Yazarlar

Yazar: S. Şimşek
Ülke: Turkey


Yazar: P. Göktaş
Ülke: Turkey


Yazar: D. COŞKUN
Ülke: Turkey


Tarihler

Yayımlanma Tarihi : 1 Temmuz 1998

Bibtex @araştırma makalesi { marumj267999, journal = {Marmara Medical Journal}, issn = {1019-1941}, eissn = {1309-9469}, address = {}, publisher = {Marmara Üniversitesi}, year = {1998}, volume = {11}, pages = {152 - 155}, doi = {}, title = {The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis}, key = {cite}, author = {Şimşek, S. and Göktaş, P. and COŞKUN, D.} }
APA Şimşek, S , Göktaş, P , COŞKUN, D . (1998). The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis. Marmara Medical Journal , 11 (3) , 152-155 . Retrieved from https://dergipark.org.tr/tr/pub/marumj/issue/25403/267999
MLA Şimşek, S , Göktaş, P , COŞKUN, D . "The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis". Marmara Medical Journal 11 (1998 ): 152-155 <https://dergipark.org.tr/tr/pub/marumj/issue/25403/267999>
Chicago Şimşek, S , Göktaş, P , COŞKUN, D . "The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis". Marmara Medical Journal 11 (1998 ): 152-155
RIS TY - JOUR T1 - The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis AU - S. Şimşek , P. Göktaş , D. COŞKUN Y1 - 1998 PY - 1998 N1 - DO - T2 - Marmara Medical Journal JF - Journal JO - JOR SP - 152 EP - 155 VL - 11 IS - 3 SN - 1019-1941-1309-9469 M3 - UR - Y2 - 1998 ER -
EndNote %0 Marmara Medical Journal The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis %A S. Şimşek , P. Göktaş , D. COŞKUN %T The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis %D 1998 %J Marmara Medical Journal %P 1019-1941-1309-9469 %V 11 %N 3 %R %U
ISNAD Şimşek, S. , Göktaş, P. , COŞKUN, D. . "The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis". Marmara Medical Journal 11 / 3 (Temmuz 1998): 152-155 .
AMA Şimşek S , Göktaş P , COŞKUN D . The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis. Marmara Med J. 1998; 11(3): 152-155.
Vancouver Şimşek S , Göktaş P , COŞKUN D . The in vitro effect of some antibiotic combinations including ofloxacin and ciprofloxacin against brucella melitensis. Marmara Medical Journal. 1998; 11(3): 155-152.