SULU SARIMSAK ÖZÜTÜNÜN SUDAN KAÇINMA STRESİNİN TETİKLEDİĞİ DERİDEKİ MAST HÜCRE DEGRANÜLASYONUNA KARŞI KORUYUCU ETKİSİ

Yıl 2005, Cilt: 18 Sayı: 3, 103 - 108, 29.06.2015

Esra Çikler Beyhan Sağlam Ali Zeybek Feriha Ercan Şule Çetinel Göksel Şener

Öz

Amaç: Bu çalışmanın amacı sulu sarımsak özütü (=aqueaous garlic extract, AGE)’ nün, sudan kaçınma stresi (SKS)’ nin tetiklediği derideki mast hücre degranülasyonu üzerindeki etkilerinin araştırılmasıdır.

Gereç ve Yöntem: Wistar albino sıçanlar, kronik sudan kaçınma stresi (SKS grubu)’ ne maruz bırakıldı. Hayvanlar SKS’ne maruz bırakıldıktan sonra 250mg/kg AGE i.p. olarak enjekte edildi (SKS + AGE grubu). Dermal mast hücreleri toluidin mavisi ile boyanarak ışık mikroskopi düzeyinde incelendi.

Sonuçlar: SKS grubunda hem granüllü hem de degranüle olmuş mast hücrelerinin sayısı kontrol grubundakilere oranla artmıştır. SKS + AGE grubundaki granüllü ve degranüle olmuş olgun mast hücrelerinin sayısı SKS grubundakilere oranla azalmıştır.

Tartışma: Kronik AGE tedavisi SKS’nin tetiklediği dermisteki mast hücre artışını ve yoğunluğunu azaltmıştır ve stresin tetiklediği deri rahatsızlıklarında tedavi edici ajan olarak kullanımı çalışmalara açık görülmektedir.

Anahtar Kelimeler: Deri, Mast hücresi, Sudan kaçınma stresi, Sulu sarımsak özütü

Anahtar Kelimeler

Deri, Mast hücresi, Sudan kaçınma stresi, Sulu sarımsak özütü

Kaynakça

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