Araştırma Makalesi
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Yıl 2022, Cilt: 35 Sayı: 2, 127 - 131, 30.05.2022
https://doi.org/10.5472/marumj.1089689

Öz

Kaynakça

  • [1] Tanrivermis Sayit A, Aslan K, Elmali M, et al. Methanolinduced toxic optic neuropathy with diffusion weighted MRI findings. Cutan Ocul Toxicol 2016;35: 337-40. doi: 10.3109/15569.527.2015.1122031
  • [2] Liesivuori J, Savolainen H. Methanol and formic acid toxicity: biochemical mechanisms. Pharmacol Toxicol 1991;69: 157-63. doi: 10.1111/j.1600-0773.1991.tb01290.x
  • [3] Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 2008;3:208-25. doi: 10.2215/CJN.03220807
  • [4] Karayel F, Turan AA, Sav A, Pakis I, Akyildiz EU, Ersoy G. Methanol intoxication: pathological changes of central nervous system (17 cases). Am J Forensic Med Pathol 2010;31: 34-6. doi: 10.1097/PAF.0b013e3181c160d9
  • [5] Rajamani R, Muthuvel A, Senthilvelan M, Sheeladevi R. Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve. Toxicol Lett 2006; 165:265-73. doi: 10.1016/j.toxlet.2006.05.005
  • [6] Farbiszewski R, Witek A, Skrzydlewska E. N-acetyl cysteine ortrolox derivative mitigatethe toxic effects of methanol on the antioxidant system of rat brain. Toxicology 2000;156: 47- 55. doi: 10.1016/s0300-483x(00)00333-4
  • [7] Kanter M. Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure. J Mol Histol 2011; 42:39-46. doi: 10.1007/s10735.010.9305-3
  • [8] Dariani S, Baluchnejadmojarad T, Roghani M. Thymoquinone attenuates astrogliosis, neurodegeneration, mossy fiber sprouting, and oxidative stress in a model of temporal lobe epilepsy. J Mol Neurosci 2013; 51:679-86. doi: 10.1007/ s12031.013.0043-3
  • [9] Dur A, Kose H, Kocyigit A, Kocaman O, Ismayilova M, Sonmez FC. The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats. Bratisl Lek Listy 2016;117:614-8. doi: 10.4149/ bll_2016_119
  • [10] Gokce EC, Kahveci R, Gokce A, et al. Neuroprotective effects of thymoquinone against spinal cord ischemiareperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis. J Neurosurg Spine 2016;24:949-59. doi: 10.3171/2015.10.SPINE15612
  • [11] Ghani MA, Barril C, Bedgood DR Jr, Prenzler PD. Measurement of antioxidant activity with the thiobarbituric acid reactive substances assay. Food Chem 2017;230:195-207. doi: 10.1016/j.foodchem.2017.02.127
  • [12] Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 2015;11:1164-78. doi: 10.5114/aoms.2015.56342
  • [13] Liu DM, Zhou S, Chen JM, Peng SY, Xia WT. The intoxication effects of methanol and formic acid on rat retina function. J Ophthalmol 2016;2016:4087096. doi: 10.1155/2016/4087096
  • [14] Diz JBM, de Souza Moreira B, Felício DC, et al. Brain-derived neurotrophic factor plasma levels are increased in older women after an acute episode of low back pain. Arch Gerontol Geriatr 2017;71:75-82. doi: 10.1016/j.archger.2017.03.005
  • [15] Kim DJ, Roh S, Kim Y, et al. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Neurosci Lett 2005;388:112-5. doi: 10.1016/j. neulet.2005.06.042
  • [16] Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation. Mol Neurobiol 2019;56:3295-312. doi: 10.1007/s12035.018.1283-6
  • [17] Gama CS, Berk M, Andreazza AC, Kapczinski F, Belmontede- Abreu P. Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation. Braz J Psychiatry 2008;30:337-40. doi: 10.1590/ s1516.444.6200800.040.0006
  • [18] Gabaizadeh R, Staecker H, Liu W, Van De Water TR. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione. Brain Res Mol Res 1997;50:71-8. doi: 10.1016/ s0169-328x(97)00173-3
  • [19] Radak Z, Toldy A, Szabo Z, et al. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int 2006;49:387-92. doi: 10.1016/j.neuint.2006.02.004

Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model

Yıl 2022, Cilt: 35 Sayı: 2, 127 - 131, 30.05.2022
https://doi.org/10.5472/marumj.1089689

Öz

Objectives: Previous studies have shown the role of oxidative stress in methanol (MeOH) neurotoxicity. In clinical practice ethanol
(EtOH) was used for the treatment of MeOH intoxication. Treatment with EtOH results in depression of the central nervous system,
which may occur even at therapeutic doses. It also induces oxidative stress. Antioxidant and neuroprotective effects of thymoquinone
(TQ) are known in different models of neurotoxicity. There are no studies investigating the protective effect of TQ against acute
MeOH intoxication. We aimed to evaluate the effect of TQ administration on serum thiobarbituric acid reactive substances (TBARS)
and Brain-Derived Neurotrophic Factor (BDNF) levels in rats with experimentally-induced MeOH intoxication.

Materials and Methods: Six groups were constituted. Methotrexate (Mtx) treatment (0.3 mg/kg/day) intraperitoneally (i.p.) was given
for 7 days to slow down the formate metabolism of all rats except controls in order to create a MeOH intoxication similar to that in
humans. On the 8th day of the experiment, 3 g/kg MeOH was injected i.p. in MeOH, EtOH and TQ groups. Four hours after MeOH
administration, 0.5 g/kg EtOH was injected i.p. in EtOH group and 30 mg/kg TQ was administered i.p. in TQ1 and TQ2 groups. In
addition, a total of 5 doses of 30 mg/kg TQ was injected i.p. 24, 48, 72 and 96 hours after the first dose in TQ2 group. Saline solution
was given i.p. in the other groups. Blood samples were obtained for evaluating serum TBARS and BDNF levels.

Results: The highest TBARS level was found in MeOH+MTx group and this increase was statistically significant as compared to
control and Mtx groups (p<0.001) . A statistically significant reduction was detected in serum TBARS levels in MeOH+Mtx+EtOH,
MeOH+Mtx+TQ1 and MeOH+Mtx+TQ2 groups (p<0.001). Maximum serum BDNF level elevation was found in MeOH+Mtx group
and this increase was statistically significant as compared to control and Mtx groups (p<0.001). Serum BDNF levels were higher in
MeOH+Mtx+EtOH, MeOH+Mtx+TQ1 and MeOH+Mtx+TQ2 groups and the difference was statistically significant (p<0.001).

Conclusions: Thymoquinone could suppress proinflammation and lipid peroxidation in MeOH intoxication, lead to rapid toxicity
adaptation, and play the role of neuroprotection more effectively than EtOH. These results may suggest that TQ could be used as an
alternative treatment option in MeOH intoxication.

Kaynakça

  • [1] Tanrivermis Sayit A, Aslan K, Elmali M, et al. Methanolinduced toxic optic neuropathy with diffusion weighted MRI findings. Cutan Ocul Toxicol 2016;35: 337-40. doi: 10.3109/15569.527.2015.1122031
  • [2] Liesivuori J, Savolainen H. Methanol and formic acid toxicity: biochemical mechanisms. Pharmacol Toxicol 1991;69: 157-63. doi: 10.1111/j.1600-0773.1991.tb01290.x
  • [3] Kraut JA, Kurtz I. Toxic alcohol ingestions: clinical features, diagnosis, and management. Clin J Am Soc Nephrol 2008;3:208-25. doi: 10.2215/CJN.03220807
  • [4] Karayel F, Turan AA, Sav A, Pakis I, Akyildiz EU, Ersoy G. Methanol intoxication: pathological changes of central nervous system (17 cases). Am J Forensic Med Pathol 2010;31: 34-6. doi: 10.1097/PAF.0b013e3181c160d9
  • [5] Rajamani R, Muthuvel A, Senthilvelan M, Sheeladevi R. Oxidative stress induced by methotrexate alone and in the presence of methanol in discrete regions of the rodent brain, retina and optic nerve. Toxicol Lett 2006; 165:265-73. doi: 10.1016/j.toxlet.2006.05.005
  • [6] Farbiszewski R, Witek A, Skrzydlewska E. N-acetyl cysteine ortrolox derivative mitigatethe toxic effects of methanol on the antioxidant system of rat brain. Toxicology 2000;156: 47- 55. doi: 10.1016/s0300-483x(00)00333-4
  • [7] Kanter M. Protective effects of thymoquinone on the neuronal injury in frontal cortex after chronic toluene exposure. J Mol Histol 2011; 42:39-46. doi: 10.1007/s10735.010.9305-3
  • [8] Dariani S, Baluchnejadmojarad T, Roghani M. Thymoquinone attenuates astrogliosis, neurodegeneration, mossy fiber sprouting, and oxidative stress in a model of temporal lobe epilepsy. J Mol Neurosci 2013; 51:679-86. doi: 10.1007/ s12031.013.0043-3
  • [9] Dur A, Kose H, Kocyigit A, Kocaman O, Ismayilova M, Sonmez FC. The anti-inflammatory and antioxidant effects of thymoquinone on ceruleine induced acute pancreatitis in rats. Bratisl Lek Listy 2016;117:614-8. doi: 10.4149/ bll_2016_119
  • [10] Gokce EC, Kahveci R, Gokce A, et al. Neuroprotective effects of thymoquinone against spinal cord ischemiareperfusion injury by attenuation of inflammation, oxidative stress, and apoptosis. J Neurosurg Spine 2016;24:949-59. doi: 10.3171/2015.10.SPINE15612
  • [11] Ghani MA, Barril C, Bedgood DR Jr, Prenzler PD. Measurement of antioxidant activity with the thiobarbituric acid reactive substances assay. Food Chem 2017;230:195-207. doi: 10.1016/j.foodchem.2017.02.127
  • [12] Bathina S, Das UN. Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 2015;11:1164-78. doi: 10.5114/aoms.2015.56342
  • [13] Liu DM, Zhou S, Chen JM, Peng SY, Xia WT. The intoxication effects of methanol and formic acid on rat retina function. J Ophthalmol 2016;2016:4087096. doi: 10.1155/2016/4087096
  • [14] Diz JBM, de Souza Moreira B, Felício DC, et al. Brain-derived neurotrophic factor plasma levels are increased in older women after an acute episode of low back pain. Arch Gerontol Geriatr 2017;71:75-82. doi: 10.1016/j.archger.2017.03.005
  • [15] Kim DJ, Roh S, Kim Y, et al. High concentrations of plasma brain-derived neurotrophic factor in methamphetamine users. Neurosci Lett 2005;388:112-5. doi: 10.1016/j. neulet.2005.06.042
  • [16] Lima Giacobbo B, Doorduin J, Klein HC, Dierckx RAJO, Bromberg E, de Vries EFJ. Brain-derived neurotrophic factor in brain disorders: Focus on neuroinflammation. Mol Neurobiol 2019;56:3295-312. doi: 10.1007/s12035.018.1283-6
  • [17] Gama CS, Berk M, Andreazza AC, Kapczinski F, Belmontede- Abreu P. Serum levels of brain-derived neurotrophic factor and thiobarbituric acid reactive substances in chronically medicated schizophrenic patients: a positive correlation. Braz J Psychiatry 2008;30:337-40. doi: 10.1590/ s1516.444.6200800.040.0006
  • [18] Gabaizadeh R, Staecker H, Liu W, Van De Water TR. BDNF protection of auditory neurons from cisplatin involves changes in intracellular levels of both reactive oxygen species and glutathione. Brain Res Mol Res 1997;50:71-8. doi: 10.1016/ s0169-328x(97)00173-3
  • [19] Radak Z, Toldy A, Szabo Z, et al. The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int 2006;49:387-92. doi: 10.1016/j.neuint.2006.02.004
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Original Articles
Yazarlar

Hasan Huseyın Kozak Bu kişi benim 0000-0001-6904-8545

Ibrahim Kılınc Bu kişi benim 0000-0002-7729-7557

Alpaslan Ozkurkculer Bu kişi benim 0000-0002-1871-3442

Yayımlanma Tarihi 30 Mayıs 2022
Yayımlandığı Sayı Yıl 2022 Cilt: 35 Sayı: 2

Kaynak Göster

APA Huseyın Kozak, H., Kılınc, I., & Ozkurkculer, A. (2022). Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model. Marmara Medical Journal, 35(2), 127-131. https://doi.org/10.5472/marumj.1089689
AMA Huseyın Kozak H, Kılınc I, Ozkurkculer A. Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model. Marmara Med J. Mayıs 2022;35(2):127-131. doi:10.5472/marumj.1089689
Chicago Huseyın Kozak, Hasan, Ibrahim Kılınc, ve Alpaslan Ozkurkculer. “Acute and Subacute Effects of Thymoquinone on Acute Methanol Intoxication: An Assessment Based on Serum TBARS and BDNF Levels in Rat Model”. Marmara Medical Journal 35, sy. 2 (Mayıs 2022): 127-31. https://doi.org/10.5472/marumj.1089689.
EndNote Huseyın Kozak H, Kılınc I, Ozkurkculer A (01 Mayıs 2022) Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model. Marmara Medical Journal 35 2 127–131.
IEEE H. Huseyın Kozak, I. Kılınc, ve A. Ozkurkculer, “Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model”, Marmara Med J, c. 35, sy. 2, ss. 127–131, 2022, doi: 10.5472/marumj.1089689.
ISNAD Huseyın Kozak, Hasan vd. “Acute and Subacute Effects of Thymoquinone on Acute Methanol Intoxication: An Assessment Based on Serum TBARS and BDNF Levels in Rat Model”. Marmara Medical Journal 35/2 (Mayıs 2022), 127-131. https://doi.org/10.5472/marumj.1089689.
JAMA Huseyın Kozak H, Kılınc I, Ozkurkculer A. Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model. Marmara Med J. 2022;35:127–131.
MLA Huseyın Kozak, Hasan vd. “Acute and Subacute Effects of Thymoquinone on Acute Methanol Intoxication: An Assessment Based on Serum TBARS and BDNF Levels in Rat Model”. Marmara Medical Journal, c. 35, sy. 2, 2022, ss. 127-31, doi:10.5472/marumj.1089689.
Vancouver Huseyın Kozak H, Kılınc I, Ozkurkculer A. Acute and subacute effects of thymoquinone on acute methanol intoxication: An assessment based on serum TBARS and BDNF levels in rat model. Marmara Med J. 2022;35(2):127-31.