D Vitamini Seviyesi Preeklampsinin Şiddetini Değiştirir mi? Tek Merkezli Vaka Kontrol Çalışması

Öz

Amaç: D vitamini eksikliği ile preeklampsinin şiddeti arasındaki ilişkiyi araştırmayı amaçladık. Materyal Metot: Preeklampsi(PE), şiddetli preeklampsi, eklampsi ve HELLP sendromu (Hemoliz, Yüksek Karaciğer enzimleri, Düşük Trombosit) hastalarında D vitamini serum düzeylerini değerlendirmeyi amaçlayan bir vaka-kontrol çalışması gerçekleştirdik. 18-40 yaşları arasında spontan vajinal doğum veya sezaryen olan toplam 69 hasta çalışmaya dahil edildi. Bulgular: Hstaların demografik verileri benzer olup şiddetli PE de yaş diğer gruplardan yüksek olarak bulundu. BMI değerlendirildiğinde şiddetli PE de hafif pe ye göre anlamlı olarak yüksek olup diğer gruplarla benzer bulundu. Tüm grupların d vit değeri ortalama 8,75±3,5 olup şiddetli PEi nin ortalaması 6,69±3 olup diğer gruplara göre anlamlı olarak düşük bulundu. Hafif PE de d vitamini seviyesi ortalama 10,99±2.91 olup tüm gruplardan yüksek olup.şiddetli PE ve HELLP sendromlu hastalara göre anlamlı olarak yüksek bulundu. Sonuç: Gebelikte yeni başlayan hipertansif bozuklukların şiddeti ile D vitamini eksikliği derecesi arasında anlamlı bir ilişki olduğunu düşünmekteyiz. Bunları önlemek ve şiddetini azaltmak içim d vitamini seviyesinin kontrolü ve tedaviye eklenmesinin hastalık seyrini olumlu etkileyeceğini düşünmekteyiz.

Does Vitamin D Status Alter the Severity af Preeclampsia? A Single-Center Case-Control Study

Abstract

Aim: We aimed to investigate the association between vitamin D deficiency and severity of preeclampsia. Material and Methods: We conducted a case-control study aiming to evaluate vitamin D serum levels in patients with preeclampsia(PE), severe preeclampsia, eclampsia and HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets). Total number of 69 patients between the ages of 18 and 40 either had a spontaneous vaginal delivery or C-section were included in the study. Results: The demographic data of the patients were similar, and age was higher in severe PE than in the other groups. When body mass index (BMI) was evaluated, the average BMI of the patients in the severe PE group was found to be significantly higher than PE and similar to the other groups. The average vitamin D levels of all groups was 8.75±3.5 and the mean of severe PE was 6.69±3, which was significantly lower than the other groups. The average vitamin D level in PE was 10.99±2.91, and it was higher than all groups and was significantly higher than patients with severe PE and HELLP syndrome. Conclusion: We think that there is a significant relationship between the severity of hypertensive disorders that begin during pregnancy and the degree of vitamin D deficiency. We think that the control of vitamin D level and its addition to the treatment will positively affect the course of the disease in order to prevent hypertensive disorders and reduce the severity of disease.

Keywords

• Pregnancy
• Pre-Eclampsia
• Hypertension
• Vitamin D

Kaynakça

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