The Correlation of C-Reactive Protein/Albumin, Mii-1 and Mii-2 Indexes With Hospitalization and Mortality in Stanford Type A Aortic Dissection

Abstract

Aim: In this study we aimed to investigate the relationship between C-Reactive Protein (CRP)/albumin ratio, MII-1 and MII-2 indexes in hospitalization and mortality due to aortic dissection. Material and Method: Patients who presented to our emergency department with a sudden-onset, sharp and stabbing chest pain and diagnosed with Stanford type A aortic dissection were included in the study. Patients’ demographics such as age and gender, hemogram parameters, ratios, indexes, hospitalization and mortality status were recorded. Demographic features, hemogram parameters, ratios and indexes were compared between the survivor and exitus patients. Results: A total of 71 patients who presented to the emergency department with sudden-onset stabbing chest pain and subsequently diagnosed with aortic dissection were included in this retrospective study. The median age of the patients was negatively correlated with albumin (r=-0.27, p=0.021), hemoglobin (r=-0.28, p=0.019). Hemoglobin values were significantly higher in male than in female patients. The median length of stay in the hospital was found as 10 (7-14) days. In the correlation analysis of the hemogram parameters, indexes and length of stay in the hospital; CRP and CRP/Albumin ratio were significantly correlated with length of stay in the hospital in positive direction. Conclusion: The results of this study point out a significant correlation between CRP, CRP/albumin ratio and length of stay in hospital. This information might be helpful in rapid decision making process for early diagnosis and treatment of the disease.

Keywords

• C-reactive protein/albumin
• Multi Inflammatory Index
• aortic dissection
• Neutrophil-to-lymphocyte ratio
• Platelet-to-lymphocyte ratio

Stanford Tip A Aort Diseksiyonunda C-Reaktif Protein/Albumin Oranı İle Mii-1 ve Mii-2 İndekslerinin Hastaneye Yatış Süresi ve Mortalite İlişkisi

Öz

Amaç: Bu çalışmamızda hastanede yatış ve aort diseksiyonuna bağlı mortalitede C-Reaktif Protein (CRP)/albümin oranı, MII-1 ve MII-2 indeksleri arasındaki ilişkiyi araştırmayı amaçladık. Material and Methot: Acil servisimize akut başlangıçlı, keskin ve saplayıcı göğüs ağrısı ile başvurup Stanford Tip A aort diseksiyonu tanısı alan hastalar çalışmaya dahil edildi. Hastaların yaş ve cinsiyet gibi demografik bilgileri, hemogram parametreleri, oranları, indeksleri, yatış ve mortalite durumları çalışmaya alındı. Taburcu olanlar ve hayatını kaybeden hastalar arasında demografik özellikler, hemogram parametreleri, oranlar ve indeksler karşılaştırıldı. Bulgular: Bu retrospektif çalışmaya, acil servisimize başvuran ve ardından aort disseksiyonu tanısı konan toplam 71 hasta dahil edildi. Hastaların medyan yaşı albümin (r=-0.27, p=0.021), hemoglobin (r=-0.28, p=0.019) ve prognostik nutrisyonel indeks (PNI) (r=-0.31, p=0.008) ile negatif korelasyon gösterdi. Hemoglobin değerleri erkek hastalarda kadınlara göre anlamlı derecede yüksekti. Hastanede kalış süresi median 10 (7-14) gün olarak bulundu. Hemogram parametrelerinin, indekslerin ve hastanede kalış sürelerinin korelasyon analizinde; CRP ve CRP/Albumin oranı hastanede kalış süresi ile pozitif yönde anlamlı olarak korele idi. Sonuç: Bu çalışmanın sonuçları, CRP, CRP/albümin oranı ve hastanede kalış süresi arasında anlamlı bir ilişkiye işaret etmektedir. Bu bilgiler hastalığın erken teşhisi ve tedavisi için hızlı karar verme sürecinde yardımcı olabilir.

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