The Effects of Taste Changes on the Quality of Life of Patients Receiving Chemotherapy Treatment

Öz

Aim: The aim of this study is to determine the effect of taste changes on quality of life in cancer patients taking chemotherapy Material and Methods: This descriptive study was conducted between January 2020 and September 2020 with cancer patients receiving chemotherapy in the inpatient and outpatient unit of a university hospital. The sample consisted of 466 cancer patients who met the inclusion criteria and received the same treatment at the same university hospital. Data were collected using the Introductory Information Form, the European Organization for Cancer Research and Treatment Quality of Life Scale Version 3 (EORTC QLQ-C30 Version 3.0), and the Chemotherapy-Induced Taste Change Scale (CiTAS). Results: While the mean total score of EORTC QLQ-C30 was 62.97±13.31, the mean total score of CiTAS was found to be 40.43±17.84. Statistically significant correlations were found between total scores of EORTC QLQ-C30 and CiTAS scales and sub-dimension scores (p<0.001). In the regression analysis, it was found that the EORTC QLQ-C30 total score average of the individuals had a statistically significant and negative effect on the CiTAS total score average. Conclusion: As a consequence, it was determined that taste changes in cancer patients receiving chemotherapy treatment negatively affect the quality of life.

Anahtar Kelimeler

• Cancer
• chemotherapy
• taste changes
• quality of life

Kaynakça

1. Referans1. Gundogan NU. Protein synthesis, cell function and genetic control of cell proliferation. In: Yegen BC, ed, Guyton and Hall Textbook of Medical Physiology Thirteenth Edition. 13th edition. Ankara: Gunes Medical Bookstores. 2017;27-43.
2. Referans2. World Health Organization. The International Agency for Research on Cancer (IARC) Cancer Tomorrow 2020. https://gco.iarc.fr/tomorrow/en/dataviz/isotype access date 20.06.2022.
3. Referans3. Turkish Statistical Institute. Death and Cause of Death Statistics, 2019 https://data.tuik.gov.tr/Bulten/Index?p=Olum-ve-Olum-Nedeni-Istatistikleri-2019-33710 access date 20.06.2022.
4. Referans4. Yıldız I. Chemotherapy. In: Can G, ed, Oncology Nursing. 2nd edition. Istanbul: Nobel Medical Bookstores. 2019;135-56.
5. Referans5. Ovayolu O, Ovayolu N. Evidence-based complementary methods in symptom management. Erciyes University Journal of Health Sciences. 2013;1:83-98.
6. Referans6. Mollaoglu M, Erdogan G. Effect on symptom control of structured information given to patients receiving chemotherapy. Eur J Oncol Nurs. 2014;18:78-84.
7. Referans7. Sozeri E, Kutluturkan S. Taste alteration in patients receiving chemotherapy. J Breast Health. 2015;11:81-7.
8. Referans8. Gamper EM, Giesinger JM, Oberguggenberger A, et al. Taste alterations in breast and gynaecological cancer patients receiving chemotherapy: prevalence, course of severity, and quality of life correlates. Acta Oncol. 2012;51:490-6.

9. Referans9. Zabernigg A, Gamper EM, Giesinger JM, et al. Taste alterations in cancer patients receiving chemotherapy: a neglected side effect? Oncologist. 2010;15: 913-20.
10. Referans10. Kano T, Kanda K. Development and validation of a chemotherapy-induced taste alteration scale. Oncol Nurs Forum. 2013;40:79-85.
11. Referans11. Sevryugin O, Kasvis P, Vigano ML, Vigano A. Taste and smell disturbances in cancer patients: a scoping review of available treatments. Support Care Cancer. 2021;29:49-66.
12. Referans12. Boltong A, Keast R. The influence of chemotherapy on taste perception and food hedonics: a systematic review. Cancer Treat Rev. 2012;38:152-63.
13. Referans13. Lyckholm L, Heddinger SP, Parker G, et al. A randomized, placebo controlled trial of oral zinc for chemotherapy-related taste and smell disorders. J Pain Palliat Care Pharmacother. 2012;26:111-4.
14. Referans14. Bilsin E, Yilmaz HB. Approach to taste alteration in cancer patients. Journal of Health Sciences and Professions (HSP). 2018;2:259-66.
15. Referans15. McLaughlin L, Mahon SM. Understanding taste dysfunction in patients with cancer. Clin J Oncol Nurs. 2012;16:171-8.
16. Referans16. Sozeri E, Kutluturkan S. The validity and reliability of Turkish version of the chemotherapy-induced taste alteration scale (CiTAS). Clin Nurs Res. 2018;27:235-49.
17. Referans17. Arslan DT, Ağırbaş İ. Measuring health outcomes: QALY and DALY. Journal of Performance and Quality in Health. 2017;13:99-126.
18. Referans18. Cankurtaran ES, Ozalp E, Soygur H, et al. Understanding the reliability and validity of the EORTC QLQ‐C30 in Turkish cancer patients. Eur J Cancer Care. 2008;17:98-104.
19. Referans19. Berk D, Durna Z, Akın S. Evaluation of oral care knowledge levels and oral care requirements in cancer patients treated with chemotherapy. Health and Society. 2020;1: 61-70.
20. Referans20. Ambaldhage VK, Puttabuddi JH, Nunsavath PN, Tummuru YR. Taste disorders: a review. J Indian Acad Oral Med Radiol. 2014;26:69-76.
21. Referans21. Yagi T, Asakawa A, Ueda H, et al. The role of zinc in the treatment of taste disorders. Recent Pat Food Nutr Agric. 2013;5:44-51.
22. Referans22. Van Oort S, Kramer E, De Groot JW, Visser O. Taste alterations and cancer treatment. Curr Opin Support Palliat Care. 2018;12:162-7.
23. Referans23. Magnani C, Mastroianni C, Giannarelli D, et al. Oral hygiene care in patients with advanced disease: an essential measure to improve oral cavity conditions and symptom management. Am J Hosp Palliat Care. 2019;36:815-9.
24. Referans24. Ozkan I, Eroğlu N. Evaluation of taste changes in lung cancer patients receiving chemotherapy. Journal of Continuing Medical Education. 2022;31:33-42.
25. Referans25. Celik A, Duzgun G, Usta YO, Yıldırım Y. The factors influencing the taste alterations in patients receiving chemotherapy. Int J Caring Sci. 2019;12:1684-90.
26. Referans26. Arikan F, Ergen M, Sozeri OE, Kutluturkan S. Taste alteration in cancer patients receiving chemotherapy: a cross-sectional study. Turk J Oncol. 2019;34:222-30.
27. Referans27. Larsen AK, Thomsen C, Sanden M, et al. Taste alterations and oral discomfort in patients receiving chemotherapy. Support Care Cancer. 2021;29:7431–9.
28. Referans28. Murtaza B, Hichami A, Khan AS, et al. Alteration in taste perception in cancer: causes and strategies of treatment. Front Physiol. 2017;8:1-10.
29. Referans29. Lewis C, Xun P, He K. Effects of adjuvant chemotherapy on recurrence, survival, and quality of life in stage II colon cancer patients: a 24-month follow-up. Support Care Cancer. 2016;24:1463-71.
30. Referans30. Sunderam S, Jeseena KJ, Kashyap V, et al. Study on quality of life of cancer patients in relation to treatment modality in a tertiary health Institute of Jharkhand. IOSR-JDMS. 2016;15:16-20.
31. Referans31. Karczmarek-Borowska B, Pelc M, Rabiej E, Grądalska-Lampart M. The quality of life of non-small cell lung cancer patients treated with chemotherapy. Adv Respir Med. 2014;82:349-57.
32. Referans32. Mohsin S, Rehman MU, Azam N, Mashhadi SF. Comparison of quality of life of cancer patients undergoing chemotherapy in a tertiary care hospital, Rawalpindi. Pak Armed Forces Med J. 2016;66:83-7.
33. Referans33. Hovan AJ, Williams PM, Stevenson-Moore P, et al. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18:1081-7.
34. Referans34. Ponticelli E, Clari M, Frigerio S, et al. Dysgeusia and health-related quality of life of cancer patients receiving chemotherapy: a cross-sectional study. Eur J Cancer Care. 2017;26:1-7.
35. Referans35. Spotten L, Corish C, Lorton C, et al. Subjective taste and smell changes in treatment-naive people with solid tumours. Support Care Cancer. 2016;24:3201-8.
36. Referans36. Braud A, Boucher Y. Taste disorder’s management: a systematic review. Clin Oral Investig. 2020;24:1889-908.
37. Referans37. Imai H, Soeda H, Komine K, et al. Preliminary estimation of the prevalence of chemotherapy-induced dysgeusia in Japanese patients with cancer. BMC Palliat Care. 2013;12: 1-5.