Yaygın Anksiyete Bozukluğu Olan Hastaların Trombosit Parametreleri ve Elektrokardiyogram Verilerinin Sağlıklı Kontrol Grubu ile Karşılaştırılması

Öz

Amaç: Yaygın anksiyete bozukluğu (YAB) olan hastalarda artmış kalp hastalığı tehdidi hakkında sınırlı veri bulunmaktadır. Geniş frontal QRS-T açısı (fQRS-T), birçok farklı hasta grubunda kardiyovasküler hastalık riskinin artmasıyla ilişkilendirilmiştir. Materyal ve Metot: Bu çalışmada YAB tanısı almış 70 hastanın sosyodemografik özellikleri, elektrokardiyogram (EKG) parametreleri ve laboratuvar değerleri 80 sağlıklı kontrol (SK) ile karşılaştırıldı. YAB'de kardiyovasküler hastalık riskini EKG parametreleri üzerinden yorumlamayı amaçladık. Bulgular: İstatistiksel analize göre, YAB'li hastalarda fQRS-T, SK'ye göre daha genişti (p<0,001). Buna göre YAB'li hastalarda bazofil sayısı istatistiksel olarak daha düşüktü (p<0,001). Eozinofil sayısı ve ortalama trombosit hacmi (MPV) YAB'li hastalarda anlamlı olarak yüksekti (sırasıyla p=0,019 ve p=0,003). Buna göre, fQRS-T ve MPV yüksek derecede koreledir (p<0,001). Yaygın Anksiyete Bozukluğu Testi-7 skoru (GAD-7) ve fQRS-T arasında pozitif korelasyon vardı (p=0,001). fQRS-T için lineer regresyon analizine göre MPV ve YAB-7 puanları fQRS-T'yi pozitif ve anlamlı olarak yordamaktadır (sırasıyla p<0,001 ve p=0,036). Sonuç: Bu çalışma literatürde YAB'li hastalarda fQRS-T'yi inceleyen ilk çalışmadır. Bu çalışmada, MPV'nin YAB'de fQRS-T'yi öngördüğünü keşfettik. Gelecekteki çalışmalar, anksiyete bozukluklarında trombosit disfonksiyonunu gösteren yöntemleri kullanarak kardiyovasküler riski öngörmede önemli olacaktır.

Anahtar Kelimeler

• Yaygın anksiyete bozukluğu
• ortalama trombosit hacmi
• frontal QRS-T açısı

Comparison of Platelet Parameters and Electrocardiogram Data in Patients with Generalized Anxiety Disorder with Healthy Control Group

Abstract

Aim: Generalized anxiety disorder (GAD) refers to the intense stress and tension felt in the face of various life events. Various studies have shown that cardiovascular diseases are more common in patients with anxiety. Frontal QRS-T (fQRS-T) has been shown to be elevated in cardiovascular diseases. In this study, the fQRS-T, hemogram, and biochemistry values of patients with GAD were compared with healthy controls (HC) and the cardiovascular risk status of GAD patients was evaluated. Material and Methods: Seventy patients with a diagnosis of GAD and no comorbidity followed in the district state hospital's psychiatry outpatient clinic were included in this study. Sociodemographic data, disease severity, hemogram, biochemistry values, electrocardiogram (ECG) data of these patients were recorded. Disease severity was evaluated with The Generalized Anxiety Disorder Test-7 (GAD-7). These values were compared with 80 HCs without any psychiatric or organic disease. The correlation of fQRS-T value with platelet parameters and age was investigated in GAD patients. Results: According to the statistical analysis, fQRS-T was wider in patients with GAD than in HC (p<.001). Accordingly, basophil count was statistically lower in patients with GAD (p<.001). Eosinophil count and mean platelet volume (MPV) were significantly elevated in patients with GAD (p=.019 and p=.003 respectively). Accordingly, fQRS-T and MPV are highly correlated (p<.001). The GAD-7 score and fQRS-T were positively correlated (p=.001). According to the linear regression analysis for fQRS-T, MPV and GAD-7 scores positively and significantly predict fQRS-T (p<.001 and p=.036 respectively). Conclusion: This study is the first in the literature to examine fQRS-T in patients with GAD. In this study, we discovered that MPV predicts fQRS-T in GAD. Future studies are essential in predicting cardiovascular risk using methods demonstrating platelet dysfunction in anxiety disorders.

Keywords

• Generalized anxiety disorder
• mean platelet volume
• frontal QRS-T angle

Kaynakça

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