Comparison of Cardiovascular Disease Risk Indicators in Bipolar Disorder Patients with Healthy Controls

Abstract

Aim: It is important to assess the likelihood of cardiovascular disease in patients with bipolar disorder (BD). In this study, indicators of increased cardiovascular disease risk on electrocardiogram (ECG) and laboratory were evaluated. Material and Methods: In the present investigation, we studied the demographic details, ECG variables, and blood test results of 90 healthy controls (HC) and 97 patients we followed for BD diagnosis. Results: Age and gender trends were similar between the BD and HC groups (p=0.844 and p=0.664). BD had a higher mean number of fragmented QRS (fQRS) than the HC group, and fQRS was more frequent (p=0.002 and p=0.007). The frontal QRS-T angle was wider in the BD group than it was in the HC group (p=0.038). Monocyte-to-lymphocyte ratio (MLR), monocytes to high-density lipoprotein cholesterol (HDL-C) ratio (MHR), and atherogenic index of plasma (AIP) were statistically greater in BD patients (p=0.021, p<0.001, and p<0.001). Conclusion: In brief, the report indicates that impaired ventricular repolarization is related to an elevation in the frontal QRS-T angle in BD. As a result, BD patients have a greater risk of cardiovascular mortality and ventricular arrhythmias. As a result, clinicians ought to have a greater understanding of the frontal QRS-T angle and conduct an ECG examination on regular controls.

Keywords

• Bipolar disorder
• frontal QRS-T angle
• fragmented QRS

Bipolar Bozuklukta Frontal QRS-T Açısı ve Fragmante QRS Sağlıklı Olgulardan Farklı mı?

Öz

Amaç: Bipolar bozukluğu (BB) olan hastalarda kardiyovasküler hastalık olasılığını değerlendirmek önemlidir. Literatüre göre frontal QRS-T kardiyovasküler hastalık göstergesi olabilir. Materyal ve Metot: Bu araştırmada, 90 sağlıklı kontrol (SK) ve BB tanısı ile takip ettiğimiz 97 hastanın demografik bilgilerini, elektrokardiyogram (EKG) değişkenlerini ve kan testi sonuçlarını inceledik. Bulgular: Yaş ve cinsiyet dağılımı BB ve SK grupları arasında benzerlik göstermekteydi (p=0,844 ve p=0,664). BB'de SK grubuna göre daha yüksek ortalama fragmente QRS (fQRS) sayısı vardı ve fQRS daha sıktı (p=0,002 ve p=0,007). Frontal QRS-T açısı BB grubunda SK grubuna göre daha genişti (p=0,038). Monosit-lenfosit oranı (MLO), monosit/yüksek yoğunluklu lipoprotein kolesterol (HDL-C) oranı (MHO) ve plazma aterojenik indeksi (PAI) BB hastalarında istatistiksel olarak daha yüksekti (p=0.021, p<0.001 ve p<0.001). Sonuç: Özetle, bu rapor bozulmuş ventriküler repolarizasyonun, BB'de frontal QRS-T açısındaki bir yükselme ile ilişkili olduğunu göstermektedir. Sonuç olarak, BB hastalarında kardiyovasküler mortalite ve ventriküler aritmi riski daha yüksektir. Sonuç olarak klinisyenler frontal QRS-T açısını daha iyi anlamalı ve rutin kontrollerde EKG incelemesi yapmalıdır.

Anahtar Kelimeler

• Bipolar disorder
• frontal QRS-T angle
• fragmented QRS

Kaynakça

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