Effect of Folic Acid in Sepsis-induced Lung Damage in Rats

Abstract

Aim: Sepsis-induced lung injury remains a critical concern with significant morbidity and mortality. This study aimed to investigate the potential therapeutic role of Folic Acid in mitigating lung injury induced by sepsis while exploring its interaction with the soluble suppression of tumorigenicity 2 (sST2) protein in an experimental rat model. Material and Methods: Rats were divided into three groups: a normal control group, a group induced with sepsis and treated with saline, and a group induced with sepsis and treated with Folic Acid (5 mg/kg). Biomarkers of oxidative stress, inflammation, respiratory gas exchange, and lung histopathology were assessed. Results: Folic Acid administration resulted in significantly decreased Malondialdehyde (MDA) levels (p<0.01) and reduced soluble ST2 levels (p<0.05) compared to the sepsis-induced saline group. Tumor necrosis factor α (TNFα) levels were markedly reduced (p<0.001), and lung histopathology demonstrated decreased alveolar inflammation and septal thickness. Additionally, improved oxygenation (PaO2) was observed following Folic Acid treatment (p<0.05), while PaCO2 remained stable. Conclusion: These findings suggest that Folic Acid protects against sepsis-induced lung injury, ameliorating oxidative stress, inflammation, and histopathological alterations. The modulation of soluble ST2 levels may implicate Folic Acid's role in immune regulation and potential crosstalk with the IL-33/ST2 pathway. Despite promising results, limitations inherent to animal models and the complexities of clinical translation warrant further investigation. This study highlights the potential of Folic Acid as a therapeutic intervention in sepsis-induced lung injury. It underscores the need for mechanistic studies and clinical trials to validate its effectiveness in human patients.

Keywords

• Sepsis
• Acute lung injury
• Soluble ST2
• Folic Acid

Kaynakça

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