The Correlation between Melasma and ABO Blood Type

Yıl 2023, Cilt: 5 Sayı: Supplement (1) - Innovations in Medicine and Healthcare in the 100th Year of the Republic, 116 - 9, 19.10.2023

Neşe Göçer Gürok

https://doi.org/10.37990/medr.1349769

Öz

Aim: Melasma is an irregular brown hyperpigmentation mostly observed in the middle face. Although genetic predisposition, ultraviolet radiation and female sex hormones have been reported as the main causes, inflammatory processes were also considered to play a role in melasma. It has been determined that blood groups play a role in many genetic and inflammatory diseases. Since the genes that encode blood types were associated with inflammation, blood type could play a role in the etiology of melasma, an inflammatory and genetically inherited disease. The present study aimed to investigate the correlation between melasma and ABO/Rh blood types, which has never been investigated before.
Material and Methods: The study was conducted 100 patients with melasma and 1000 healthy controls. The patient and healthy control blood types and Rh factor data were collected from the hospital automation system retrospectively.
Results: Female gender ratio was significantly higher in the patient group compared to the control group (p<0.05). The mean patient age was significantly higher when compared to the controls (p<0.05). The analysis of the ABO blood type distribution revealed that the AB-type incidence was significantly higher in melasma patients, while the B-type incidence was higher in the control group (χ2:4.512; p<0.05). There was no significant difference between the A and 0 blood types in the patient and control groups. Rh positivity was significantly higher in the patient group (p<0.05).
Conclusion: Since this is the first ABO blood type study conducted on melasma patients, multicenter studies with large samples are needed to clarify our findings.

Anahtar Kelimeler

ABO blood types , melasma , hyperpigmentation.

Destekleyen Kurum

None

Proje Numarası

None

Teşekkür

None

Kaynakça

• Taraz M, Niknam S, Ehsani AH. Tranexamic acid in treatment of melasma: a comprehensive review of clinical studies. Dermatol Ther. 2017;30:e12465.
• Zhou LL, Baibergenova A. Melasma: systematic review of the systemic treatments. Int J Dermatol. 2017;56:902-8.
• Rajanala S, Maymone MBC, Vashi NA. Melasma pathogenesis: a review of the latest research, pathological findings, and investigational therapies. Dermatol Online J. 2019;25:13030/qt47b7r28c.
• Kwon SH, Park KC. Melasma and common pigmentary dermatoses in Asian individuals and an overview of their treatment. J Clin Investigat Dermatol. 2014;2:8.
• McKesey J, Tovar-Garza A, Pandya AG. Melasma treatment: an evidence-based review. Am J Clin Dermatol. 2020;21:173-225.
• Jiang J, Akinseye O, Tovar-Garza A, Pandya AG. The effect of melasma on self-esteem: a pilot study. Int J Womens Dermatol. 2018;4:38-42.
• Handel AC, Miot LDB, Miot HA. Melasma: a clinical and epidemiological review. An Bras Dermatol. 2014;89:771-82.
• Noh TK, Choi SJ, Chung BY, et al. Inflammatory features of melasma lesions in Asian skin. J Dermatol. 2014;41:788-94.
• Kwon S, Hwang Y, Lee S, Park K. Heterogeneous pathology of melasma and its clinical implications. Int J Mol Sci. 2016;17:824.
• Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev. 2015;28:801-70.
• Stowell CP, Stowell SR. Biologic roles of the ABH and Lewis histo-blood group antigens Part I: infection and immunity. Vox Sang. 2019;114:426-42.
• Göçer Gürok N. The correlation between ABO blood types and acne vulgaris severity. J Cosmet Dermatol. 2023;22:2318-23.
• Ozturk M, An I. Do blood groups play a role in etiology of rosacea? J Cosmet Dermatol. 2020;19:400-3.
• İslamoğlu ZGK, Unal M. Is there an association of ABO blood groups and Rhesus factor with alopecia areata? J Cosmet Dermatol. 2018;17:1271-4.
• Jacoub K, Al-Eisawi Z. ABO blood group and skin cancers. Clin Hemorheol Microcirc. 2022;81:359-71.
• Sehgal VN, Dube B. ABO blood groups and vitiligo. J Med Genet. 1968;5:308-9.
• Olasode OA. Is ABO blood grouping a gene marker for vitiligo? Niger J Med. 2002;11:193.
• Önder S, Etgü FY. Is There an association between blood group types and chronic spontaneous urticaria? Int J Acad Med Pharm. 2021;3:208-11.
• Karadağ A. Comparison of the distribution of blood groups in inflammatory rheumatic diseases and healthy subjects. Cumhuriyet Medical Journal. 2019;41:516-23.
• Zhang BL, He N, Huang YB, et al. ABO blood groups and risk of cancer: a systematic review and meta-analysis. Asian Pac J Cancer Prev. 2014;15:4643-50.
• Behra D, Joshi D. Distribution of ABO blood group and RH (D) factor in Western Rajasthan. J Med Res. 2013;3:73-5.
• Heggelund JE, Varrot A, Imberty A, Krengel U. Histo-blood group antigens as mediators of infections. Curr Opin Struct Biol. 2017;44:190-200.
• Ewald DR, Sumner SC. Blood type biochemistry and human disease. Wiley Interdiscip Rev Syst Biol Med. 2016;8:517-35.
• Neshat S, Rezaei A, Farid A, et al. Cardiovascular diseases risk predictors: ABO blood groups in a different role. Cardiol Rev. 2022;9. doi: 10.1097/CRD.0000000000000463.
• Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021;23:6629060.
• Xie J, Qureshi AA, Li Y, ABO blood group and incidence of skin cancer. PLoS One. 2010;5:e11972.
• Chang L, Pei J, Li C, et al. Incidence and metastasis of cutaneous malignant melanoma with respect to ABO blood groups: a case-controlled study in northeast of China. PLoS One. 2014;9:e88096.
• Altunisik N, Turkmen D, Kayhan Tetik B, Sener S. Evaluation of the relationship between androgenetic alopecia and blood groups and Rhesus factor. Int J Clin Pract. 2021;75:e13647.