Is There a Relationship between Insulin Resistance and Eosinophil, Inflammatory Parameters Neutrophil to lymphocyte ratio, C-Reactive Protein Values?

Yıl 2024, Cilt: 6 Sayı: 1, 32 - 36, 31.01.2024

Meltem Yiğit , Özgür Olukman

https://doi.org/10.37990/medr.1398279

Öz

Aim: The relationship between insulin resistance and inflammation and atopy is a matter of curiosity and various studies have been conducted. Study results show differences. We aimed to evaluate the relationship between insulin resistance and inflammation and atopy using C-Reactive Protein (CRP) and Neutrophil to lymphocyte ratio (NLR) as eosinophils and inflammatory indices and to determine whether the low-cost hemogram can be used as a reliable marker.
Material and Method: Between May 2022 and November 2023, 1566 children admitted to the Pediatrics outpatient clinics of İzmir Bakırçay University Çiğli Training and Research Hospital were retrospectively screened. A total of 349 pediatric patients without any known chronic disease and with complete blood count, CRP and HOMA-IR levels were retrospectively included in the study.
Results: Individuals with HOMA-IR<2.5 were considered as control group and those with HOMA-IR≥2.5 were considered as children with insulin resistance. As a result of Mann-Whitney-U test performed according to HOMA-IR groups, age and NLR parameters were found to be higher in the group with insulin resistance. This result was statistically significant (p<0.05). The results were not significant in eosinophil (p=0.324) and CRP (p=0.352) parameters.
Conclusion: NLR value may be a credible predictive marker of insulin resistance. Inexpensive and simple complete blood count measurement may help in the early diagnosis of Type 2 DM and in the design of treatments. In addition, due to the increasing risk of insulin resistance with age, education on conscious nutrition can be given in schools during adolescence.

Anahtar Kelimeler

Neutrophil-to-lymphocyte ratio , Insulin resistance , Inflammation , eosinophils , CRP

Kaynakça

• Lang JE. Exercise, obesity, and asthma in children and adolescents. J Pediatr (Rio J). 2014;90:215-7.
• Di Genova L, Penta L, Biscarini A, et al. Children with obesity and asthma: which are the best options for their management?. Nutrients. 2018;10:1634.
• Shoelson S, Lee J, Goldfine A. Inflammation and insulin resistance. J Clin Invest. 2006;116:1793-801. Erratum in: J Clin Invest. 2006;116:2308.
• Visser M, Bouter LM, McQuillan GM, et al. Low-grade systemic inflammation in overweight children. Pediatrics. 2001;107:E13.
• Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab. 2001;280:E745-51.
• Khansari N, Shakiba Y, Mahmoudi M. Chronic inflammation and oxidative stress as a major cause of age-related diseases and cancer. Recent Pat Inflamm Allergy Drug Discov.2009;3:73-80.
• Strunk RC, Colvin R, Bacharier LB, et al. Airway obstruction worsens in young adults with asthma who become obese. J Allergy Clin Immunol Pract. 2015;3:765-71.e2.
• Nahhas M, Bhopal R, Anandan C, et al. Investigating the association between obesity and asthma in 6- to 8-year-old Saudi children: a matched case–control study. NPJ Prim Care Respir Med. 2014;24:14004.
• Zazula AD, Précoma-Neto D, Gomes AM, et al. An assessment of neutrophils/lymphocytes ratio in patients suspected of acute coronary syndrome. Arq Bras Cardiol. 2008;90:31-6. Erratum in: Arq Bras Cardiol. 2008;90:309.
• Von Vietinghoff S, Ley K. Homeostatic regulation of blood neutrophil counts. J Immunol. 2008;181:5183-8.
• Tamhane UU, Aneja S, Montgomery D, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008;102:653-7.
• Núñez J, Núñez E, Bodí V, et al. Usefulness of the neutrophil to lymphocyte ratio in predicting long-term mortality in ST segment elevation myocardial infarction. Am J Cardiol. 2008;101:747-52.
• Turkmen K, Guney I, Yerlikaya FH, Tonbul HZ. The relationship between neutrophil-to-lymphocyte ratio and inflammation in end-stage renal disease patients. Ren Fail. 2012;34:155-9.
• Park HS, Park JY, Yu R. Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6. Diabetes Res Clin Pract. 2005;69:29-35.
• Lee SE, Baek JY, Han K, Koh EH. Insulin resistance increases serum immunoglobulin e sensitization in premenopausal women. Diabetes Metab J. 2021;45:175-82.
• Thuesen BH, Husemoen LL, Hersoug LG, et al. Insulin resistance as a predictor of incident asthma-like symptoms in adults. Clin Exp Allergy. 2009;39:700-7.
• Ma J, Xiao L, Knowles SB. Obesity, insulin resistance and the prevalence of atopy and asthma in US adults. Allergy. 2010;65:1455-63.
• Liying Z, Tingwei S, Min X, et al. Eosinophil inversely associates with type 2 diabetes and insulin resistance in Chinese adults. PLoS One. 2013;8:e67613.
• Cardet JC, Ash S, Kusa T, et al. Insulin resistance modifies the association between obesity and current asthma in adults. Eur Respir J.2016;48:403-10.
• Tabák AG, Kivimäki M, Brunner EJ, et al. Changes in C-reactive protein levels before type 2 diabetes and cardiovascular death: the Whitehall II study. Eur J Endocrinol. 2010;163:89-95.
• Meiqin L, Peng L, Ru T, et al. Relationship between neutrophil-lymphocyte ratio and insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMC Endocr Disord. 2015;15:9.
• Atlı H, Önalan E, Yakar B. The effect of insulin resistance on inflammation markers in individuals with obesity. Medical Science and Discovery. 2021;8:619-22.
• Karakaya S, Altay M, Efe FK, et al. The neutrophil-lymphocyte ratio and its relationship with insulin resistance in obesity. Turk J Med Sci. 2019;49:245-8.
• Saricam O. Hematological and inflammatory parameters effective on inflammationand insulin resistance in obesity. KSU Medical Journal. 2023;18:39-44.
• Bizu G, Luis R, Tania, et al. Association between insulin resistance and c-reactive protein among Peruvian adults. Diabetol Metab Syndr. 2010;2:30.
• Güneş HK, Gerald R, Steven L. Relationship between insulin resistance and c-reactive protein in a patient population treated with second generation antipsychotic medications. Int Clin Psychopharmacol. 2011;26:43-7.
• Yang H, Gong R, Liu M, et al. HOMA-IR is positively correlated with biological age and advanced aging in the US adult population. Eur J Med Res. 2023;28:470.
• Strazhesko I, Tkacheva O, Boytsov S, et al. Association of insulin resistance, arterial stiffness and telomere length in adults free of cardiovascular diseases. PLoS ONE. 2015;10:e0136676.