Availability of Mean Platelet Volume and Neutrophil/Lymphocyte Ratio in Control of Helicobacter Pylori Eradication

Yıl 2024, Cilt: 6 Sayı: 1, 120 - 123, 31.01.2024

Hüseyin Kaçmaz , Ali Rıza Çalışkan

https://doi.org/10.37990/medr.1406157

Öz

Aim: The most common chronic bacterial infection in humans is Helicobacter pylori (HP) and has been proven to cause gastritis, recurrent peptic ulcers, duodenal ulcers, and gastric cancer. We investigated the neutrophil-lymphocyte ratio (NLR) and the mean platelet volume (MPV) in the control of HP infection eradication success.
Material and Method: Patients with HP infection in endoscopic biopsy performed due to dyspeptic complaints were included in this retrospective analysis. Quadruple antibiotic eradication therapy was given to the patients for 14 days. Pre- and post-treatment complete blood count parameters of 217 patients whose eradication treatment was successful were evaluated.
Results: There was a statistically significant decrease in the neutrophil count after treatment compared to before treatment (p<0.001). NLR after treatment was significantly lower than before treatment (p=0.002). MPV value after treatment showed a statistically significant increase compared to before treatment (p<0.001).
Conclusion: In our study, a significant difference was observed between pre-/post-treatment neutrophil value, neutrophil/lymphocyte ratio, and MPV value.

Anahtar Kelimeler

mean platelet volume; , gastritis; , neutrophil/lymphocyte ratio.

Etik Beyan

Yes

Destekleyen Kurum

No

Proje Numarası

2021/05-18

Teşekkür

Thanks to editorial service

Kaynakça

• Cave DR. Transmission and epidemiology of Helicobacter pylori. Am J Med. 1996;100:12-7.
• Malfertheiner P, Megraud F, O'morain C, et al. Management of helicobacter pylori infection—the Maastricht V/Florence consensus report. Gut. 2017;66:6-30.
• Goodwin CS, Worsley BW. Microbiology of Helicobacter pylori. Gastroenterol Clin North Am. 1993;22:5-19.
• Marshall BJ, Warren JR. Unidentified curved bacilli in the stomach of patients with gastritis and peptic ulceration. Lancet. 1984;1:1311-5.
• Hunt R, Sumanac K, Huang JQ. Review article: should we kill or should we save Helicobacter pylori?. Aliment Pharmacol Ther. 2001;15:51-9.
• Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13 C-Urea breath test. BMC Public Health. 2013;13:1215.
• Chey WD, Wong BC; Practice Parameters Committee of the American College of Gastroenterology. American College of Gastroenterology guideline on the management of Helicobacter pylori infection. Am J Gastroenterol. 2007;102:1808-25.
• Fagoonee S, Pellicano R. Helicobacter pylori: molecular basis for colonization and survival in gastric environment and resistance to antibiotics. A short review. Infect Dis (Lond). 2019;51:399-408.
• Ernst P, Jin Y, Reyes V, Crowe S. The role of the local immune response in the pathogenesis of peptic ulcer formation. Scand J Gastroenterol Suppl. 1994;205:22-8.
• Han S, Liu Y, Li Q, et al. Pre-treatment neutrophil-to-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma. BMC Cancer. 2015;15:617.
• Jafarzadeh A, Akbarpoor V, Nabizadeh M, et al. Total leukocyte counts and neutrophil-lymphocyte count ratios among Helicobacter pylori-infected patients with peptic ulcers: independent of bacterial CagA status. Southeast Asian J Trop Med Public Health. 2013;44:82-8.
• Kim TJ, Pyo JH, Lee H, et al. Lack of association between helicobacter pylori infection and various markers of systemic inflammation in asymptomatic adults. Korean J Gastroenterol. 2018;72:21-7.
• Farah R, Khamisy-Farah R. Association of neutrophil to lymphocyte ratio with presence and severity of gastritis due to Helicobacter pylori infection. J Clin Lab Anal. 2014;28:219-23.
• McColl KE. Clinical practice. Helicobacter pylori infection. N Engl J Med. 2010;362:1597-604.
• Asil M, Dertli R. Neutrophil to lymphocyte ratio is increased in chronic helicobacter pylori infection and returns to normal after successful eradication. J Turgut Ozal Med Cent. 2016;23:409-13.
• Ferhatoğlu MF, Şenol K, Kartal A, et al. Importance of neutrophil/ lymphocyte ratio is important in helicobacter pylori eradication treatment follow-up. Med J Ankara Tr Res Hosp. 2019;52:38-42.
• Kondo Y, Joh T, Sasaki M, et al. Helicobacter pylori eradication decreases blood neutrophil and monocyte counts. Aliment Pharmacol Ther. 2004;20:74-9.
• Davì G, Neri M, Falco A, et al. Helicobacter pylori infection causes persistent platelet activation in vivo through enhanced lipid peroxidation. Arterioscler Thromb Vasc Biol. 2005;25:246-51.
• Umit H, Umit EG. Helicobacter pylori and mean platelet volume: a relation way before ımmune thrombocytopenia. Eur Rev Med Pharmacol Sci. 2015;19:2818-23.
• Sahin Y, Gubur O, Tekingunduz E. Relationship between the severity of Helicobacter pylori infection and neutrophil and lymphocyte ratio and mean platelet volume in children. Arch Argent Pediatr. 2020;118:e241-5.
• Kaplan M, Ates I, Yuksel M, et al. The role of the PLR–NLR combination in the prediction of the presence of helicobacter pylori and its associated complications.Saudi J Gastroenterol. 2018;24:294-300.
• Ali SA, Gaufri NEAM. Platelet characterization in helicobacter pylori patients. Open Access Library Journal. 2017;4:e3637.
• Dolan RD, McSorley ST, Horgan PG, et al. The role of the systemic inflammatory response in predicting outcomes in patients with advanced inoperable cancer: systematic review and meta-analysis. Crit Rev Oncol Hematol. 2017;116:134-46.