Oxidative Stress and Anti-Carbonic Anhydrase Antibody Levels in Early Preeclampsia: A Clinical Investigation

Abstract

Aim: Preeclampsia (PE) is a dangerous condition that affects 3–5% of pregnancies and has a substantial risk of death and morbidity for both mothers and newborns. The processes behind the etiology of PE are not entirely known, despite the fact that it is the primary cause of illness and death among mothers globally. In order to further understand the correlations between these parameters, this study will look at the levels and presence of anti-carbonicanhydrase (CA) I and II antibodies, total oxidant capacity (TOC), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) in early PE. Material and Method: The research analyzed 30 pregnant women with early PE and 30 normal pregnant women as the control group. Serum levels of anti-CAI (pg/mL), anti-CAII (ng/mL), MDA (nmol/mL), TOS (U/mL), T-AOC (U/mL) were measured and compared between the two groups. Results: Significant variations were noted in the amount of anti-CA I, anti-CA II, MDA, TOS, and T-AOC (both p<0.05) between the control group and the early PE group. More specifically, oxidative stress indicators were changed and increased levels of anti-CA I and anti-CA II were seen in the early PE group in comparison with the control group. Conclusion: The findings show that elevated amounts of anti-CAI and anti-CAII antibodies may serve as predictive markers for early PE. The significant differences in oxidative stress parameters further support the oxidative stress involvement in the pathogenesis of early PE. However, more extensive Research is required to validate these results and clarify the mechanisms underlying PE.

Keywords

• Antioxidants
• carbonic anhydrase
• malondialdehyde
• oxidants
• oxidative stress
• preeclampsia

Kaynakça

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