Oxidative Stress and Anti-Carbonic Anhydrase Antibody Levels in Early Preeclampsia: A Clinical Investigation

Yıl 2024, Cilt: 6 Sayı: 3, 567 - 573, 24.09.2024

Ayse Sebnem Erenler , Rauf Melekoğlu , Tuğba Raika Kıran , Feyza İnceoğlu

https://doi.org/10.37990/medr.1537752

Öz

Aim: Preeclampsia (PE) is a dangerous condition that affects 3–5% of pregnancies and has a substantial risk of death and morbidity for both mothers and newborns. The processes behind the etiology of PE are not entirely known, despite the fact that it is the primary cause of illness and death among mothers globally. In order to further understand the correlations between these parameters, this study will look at the levels and presence of anti-carbonicanhydrase (CA) I and II antibodies, total oxidant capacity (TOC), total antioxidant capacity (T-AOC), and malondialdehyde (MDA) in early PE.
Material and Method: The research analyzed 30 pregnant women with early PE and 30 normal pregnant women as the control group. Serum levels of anti-CAI (pg/mL), anti-CAII (ng/mL), MDA (nmol/mL), TOS (U/mL), T-AOC (U/mL) were measured and compared between the two groups.
Results: Significant variations were noted in the amount of anti-CA I, anti-CA II, MDA, TOS, and T-AOC (both p<0.05) between the control group and the early PE group. More specifically, oxidative stress indicators were changed and increased levels of anti-CA I and anti-CA II were seen in the early PE group in comparison with the control group.
Conclusion: The findings show that elevated amounts of anti-CAI and anti-CAII antibodies may serve as predictive markers for early PE. The significant differences in oxidative stress parameters further support the oxidative stress involvement in the pathogenesis of early PE. However, more extensive Research is required to validate these results and clarify the mechanisms underlying PE.

Anahtar Kelimeler

Antioxidants , carbonic anhydrase , malondialdehyde , oxidants , oxidative stress , preeclampsia

Etik Beyan

Ethical approval for the study was obtained from the İnonu University Faculty of Medicine Clinical Research Ethics Committee (ethical approval number:2021/113). The researchers committed to comply with the principles of the World Medical Association Declaration of Helsinki (including the recruitments adopted in 2008) and the Good Clinical Practice (GCP) Guide, which was enacted on December 29, 1995, as an annex to the circular numbered 51748 by the Turkish Ministry of Health.

Destekleyen Kurum

This research was supported by the Scientific Research Supportment Commitee of Malatya Turgut Ozal University, Malatya, Turkiye (Project no: .2021/2)

Proje Numarası

2021/2

Kaynakça

• Chappell LC, Seed PT, Briley AL, et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: a randomised trial. Lancet. 1999;354:810-6.
• Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019;366:l2381.
• Roberts JM, Rich-Edwards JW, McElrath T, et al. Subtypes of preeclampsia: recognition and determining clinical usefulness. Hypertension. 2021;77:1430-41.
• Brosens I, Pijnenborg R, Vercruysse L, Romero R. The "Great Obstetrical Syndromes" are associated with disorders of deep placentation. Am J Obstet Gynecol. 2011;204:193-201.
• Yung HW, Atkinson D, Campion-Smith T, et al. Differential activation of placental unfolded protein response pathways implies heterogeneity in causation of early- and late-onset pre-eclampsia. J Pathol. 2014;234:262-76.
• Buonocore G, Perrone S, Tataranno ML. Oxygen toxicity: chemistry and biology of reactive oxygen species. Semin Ftal Neonat Med. 2010;15:186-90.
• Wang Y, Walsh SW. Antioxidant activities and mRNA expression of superoxide dismutase, catalase and glutathione peroxidase in normal and preeclamptic placentas. J Soc Gynecol Investig. 1996:3:179-84.
• Rojas R, Apodaca G. Immunoglobulin transport across polarized epithelial cells. Nature Rev Mol Cell Bio. 2002;3:944-55.
• Galbiati S, Gabellini D, Ambrosi A, et al. Early increase in circulating carbonic anhydrase IX: A potential new predictive biomarker of preeclampsia. Front Mol Biosci. 2023;19:10:1075604.
• Carreiras MM, Proverbio T, Proverbio F, Marín R. Preeclampsia and calcium-ATPase activity of red cell ghosts from neonatal and maternal blood. Hypertens Pregnancy. 2002;21:97-107.
• Sagrillo-Fagundes L, Laurent L, Bienvenue-Pariseault J, Vaillancourt C. In vitro induction of hypoxia/reoxygenation on placental cells: a suitable model for understanding placental diseases. Methods Mol Biol. 2018;1710:277-83.
• Madazli R, Benian A, Gumustas K, et al. Lipid peroxidation and antioxidants in preeclampsia. Eur J Obstet Gynecol Reprod Biol. 1999;85:205-8.
• Yoshio Y, Rintaro S, Shunji S, et al. Relationship between plasma malondialdehyde levels and adenosine deaminase activities in preeclampsia. Clin Chim Acta. 2002;322:169-73.
• Alexa ID, Jerca L. The role of oxidative stress in the etiology of preeclampsia. Rev Med Chir Soc Med Nat Lasi. 1996;100:131-5.
• Sheikhi M, Sharifi-Zahabi E, Paknahad Z. Dietary Antioxidant Capacity and Its Association with Preeclampsia. Clin Nutr Res. 2017;6:47-54. Erratum in: Clin Nutr Res. 2017;6:145-6.
• Chaiworapongsa T, Chaemsaithong P, Yeo L, Romero R. Pre-eclampsia part 1: current understanding of its pathophysiology. Nat Rev Nephrol. 2014;10:466-80.
• D’Souza V, Rani A, Patil V, et al. Increased oxidative stress from early pregnancy in women who develop preeclampsia. Clin Exp Hypertens. 2016;38:225-32.
• Liu N, Guo YN, Gong LK, Wang BS. Advances in biomarker development and potential application for preeclampsia based on pathogenesis. Eur J Obstet Gynecol Reprod Biol X. 2020;9:9:100119.
• Yiyenoglu OB, Ugur MG, Ozcan HC, et al. Assessment of oxidative stress markers in recurrent pregnancy loss: a prospective study. Arch Gynecol Obstet. 2014;289:1337-40.