Investigation of the Effects of Lycopene Against Cisplatin-Induced Renal Damage in Rats: A Histopathological Study

Abstract

Aim: This study aimed to investigate the protective effect of lycopene (LP) on kidney damage induced by cisplatin (CPT), which is used as a potent agent in chemotherapy, in rats. Material and Method: A total of 35 female Wistar albino rats between 220-250 grams which were 2-4 months old were included in the study. The rats were divided into 5 equal groups as control (Cont) group, CPT group, CPT+LP group, LP group and Dimethyl sulfoxide (DMSO) (solvent) group. Cont group did not receive any treatment during the 7-day long experiment. Rats in the CPT group were administered a single dose of 7 mg/kg CPT intraperitoneally on the first day of the experiment. CPT+LP group was administered 5 mg/kg of LP dissolved in DMSO intraperitoneally every day for 7 days after CPT was administered at the mentioned dose and duration. LP and DMSO groups were intraperitoneally administered 5 mg/kg of LP dissolved in DMSO and 1 ml/kg 0.1% DMSO, respectively during the experiment. At the end of the experiment, kidney tissues taken from the rats were evaluated histopathologically. Results: When the histopathological analyses were evaluated, it was found that glomerular shrinkage, tubular vacuolisation, desquamous epithelium and interstitial hemorrhage were statistically more intense in the CPT group when compared with the Cont, DMSO and LP groups. In the CPT+LP group, cellular organization in the renal tissue was found to be close to normal when compared with the CPT group and it was found that apart from other parameters, especially glomerular atrophy was minimised by LP (p<0.01). Conclusion: In conclusion, it was shown that LP administration alleviated nephrotoxicity, which is one of the primary adverse effects of CPT in rats.

Keywords

• Cisplatin
• lycopene
• nephrotoxicity
• histopathology
• rat

Kaynakça

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