Relationship Between Helicobacter pylori and Blood Groups

Öz

Aim: It was aimed to see the relationship between Helicobacter pylori (H. pylori), a bacterium that settles in various parts of the stomach and duodenum, and blood groups and its distribution among blood groups. Material and Method: A retrospective analysis was conducted on 285 patients who underwent H. pylori testing between 2020 and 2022. Data on patients’ age, sex, H. pylori test results, and blood types were collected. Student's t-test was used for age comparisons and chi-square was used for gender distribution. Blood group distributions were expressed as percentages. Results: In the study, it was determined that 70% of H. pylori positive patients were female and 30% were male. The H. pylori negative individuals were reported as 21.4% male and 78.6% female and no significant difference was found in terms of gender. When age groups were analysed, H. pylori positive patients were found to be 53.5±15.8 years old and negative patients were found to be 52.4±15.8 years old and no significance was found (p=0.57). Among the patients with H. pylori, 10.9% were in group AB, 13.6% in group B, 37.3% in group O and 38.2% in group A. Furthermore, there is no significant distinction between negative patients and the opposite groups (p=0.242) Conclusion: The findings suggest that H. pylori infection is more frequently observed in individuals with blood groups A and O, indicating that these blood types may be associated with a higher susceptibility to the infection.

Anahtar Kelimeler

• H. pylori
• blood groups
• blood group A
• blood group 0

Etik Beyan

This study was approved by Ordu University Clinical Research Ethics Committee with decision number 107 on 14.04.2023.

Kaynakça

1. Marshall BJ. Helicobacter pylori. Am J Gastroenterol. 1994;89:S116-28.
2. Alarcon T, Martinez MJ, Urruzuno P, et al. Prevalence of CagA and VacA antibodies in children with H. pylori-associated peptic ulcer compared to prevalence in pediatric patients with active or nonactive chronic gastritis. Clin Diagn Lab Immunol. 2000;7:842-4.
3. Goosen C, Theron J, Ntsala M, et al. Evaluation of a novel heminested PCR assay based on the phosphoglucosamine mutase gene for detection of H. pylori in saliva and dental plaque. J Clin Microbiol. 2002;40:205-9.
4. Kayar Y, Pamukçu Ö, Eroğlu H, et al. Relationship between H. pylori Infections in diabetic patients and inflammations, metabolic syndrome and complications. Int J Chronic Dis. 2015;2015:290128.
5. de Mattos LC, Rodrigues Cintra J, Sanches FE, et al. ABO, Lewis, secretor and non-secretor phenotypes in patients infected or uninfected by the Helicobacter pylori bacillus. Sao Paulo Med J. 2002;120:55-8.
6. Henriksson K, Uribe A, Sandstedt B, Nord CE. H. pylori infection, ABO blood group, and effect of misoprostol on gastroduodenal mucosa in NSAID-treated patients with rheumatoid arthritis. Dig Dis Sci. 1993;38:1688-96.
7. Borcn T, Faik P, Roth KA, et al. Attachment of H. pylori to human gastric epithelium mediated by blood group antigens. Science. 1993;262:1892-5.
8. Reid ME, Bird GW. Associations between human red cell blood group antigens and disease. Transfus Med Rev. 1990;4:47-55.

9. Mentis A, Blackwell CC, Weir DM, et al. AB O blood group, secretuar status and detection of H. pylori among patients with gastric or duodenal ulcers. Epidemiol Infect. 1991;106:221-9.
10. Lindén S, Nordman H, Hedenbro J, et al. Strain-and blood group– dependent binding of H. pylori to human gastric MUC5AC glycoforms. Gastroenterol. 2002;123:1923-30. Erratum in: Gastroenterology. 2003;124:588.
11. Seyda T, Derya C, Fusun A, Meliha K. The relationship of H. pylori positivity with age, sex, and ABO/Rhesus blood groups in patients with gastrointestinal complaints in Turkey. Helicobacter. 2007;12:244-50.
12. Konür Ş, Kayar Y, Dertli R, et al. The relationship between H. pylori infection and blood group. Van Med J. 2020;27:514-9.
13. Şenkaynağı A, Yıldız M. The relationship among H. pylori positivity, acute phase reactants, blood groups and tumor markers in urea breathe test. Middle Black Sea J Health Sci. 2017;3:13-9.
14. Nalbant A, Aydın A. Association of H. pylori infection with vitamin D, hemogram parameters, and blood group. Academic Journal of Gastroenterology. 2017;16:01-5.
15. Önder T, Hasbal NB, Kahramanca Ş, Anuk T. The relationship between H. pylori infection and sex, blood groups and rhesus factor in patients with chronic gastritis. İKSST Derg. 2016;8:93-6.
16. Sarmış A, Torun C, Şeneldir H, Tuncer İ. The relationship between AB0/Rhesus blood group antigens with the presence of H. pylori in gastroduodenal biopsy- retrospective analyze of 1774 patient data. Van Med J. 2023;30:286-92.
17. Rizzato C, Kato I, Plummer M, et al. Risk of advanced gastric precancerous lesions in H. pylori infected subjects is influenced by ABO blood group and cagA status. Int J Cancer. 2013;133:315-22.
18. Gisi K, İspiroğlu M. Are ABO blood groups associated with premalignant gastric lesions and H. pylori?. Laparosc Endosc Surg Sci. 2022;29:1-5.
19. Tüzün A, Doğru T, Çetin C, et al. H. pylori Infection and blood group antigens. Turkiye Klinikleri J Gastroenterohepatol. 1998;9:113-6.