Obez Adelosan Çocuklarda Hematolojik Parametreler, Demir Düzeyi Ve D Vitamini Düzeylerinin Değerlendirilmesi

Öz

AMAÇ: Bu çalışmanın amacı, çocukluk çağı obezitesinde D vitamini eksikliğinin rolünü, yaşa bağlı farklılıklar ve ilişkili hematolojik ve inflamatuar parametreler açısından araştırmaktır. GEREÇ VE YÖNTEM: Retrospektif kohort olarak tasarlanan bu çalışmada 8.010 tıbbi kayıt incelenmiş ve toplam 1.134 çocuk çalışmaya dahil edilmiştir. Katılımcılar üç gruba ayrılmıştır: Obez (Grup 1), Fazla Kilolu (Grup 2) ve Sağlıklı (Grup 3). Beyaz kan hücresi (WBC), C-reaktif protein (CRP), alanin aminotransferaz (ALT), demir ve D vitamini düzeyleri olmak üzere çeşitli laboratuvar parametreleri gruplar arasında analiz edilmiştir. BULGULAR: Obezite ile WBC ve CRP düzeyleri arasında anlamlı bir ilişki bulunmuştur. Adölesan bireylerde demir düzeyleri ile obezite arasında bir korelasyon gözlenmiş, ancak bu yaş grubunda D vitamini düzeyleri ile obezite arasında anlamlı bir ilişki saptanmamıştır. Özellikle, erken çocukluktan sonra D vitamini eksikliğinin düzeltilmesi obezite riskini azaltmamış, bu da müdahale için adölesan öncesi dönemin kritik bir zaman dilimi olduğunu göstermiştir. SONUÇ: Bulgular, çocukluk çağı obezitesinin önlenmesi ve yönetiminde D vitamini eksikliğinin erken dönemde tespit edilip düzeltilmesinin önemini ortaya koymaktadır. Erken müdahale stratejileri, uzun vadeli obezite riskinin azaltılmasında daha etkili olabilir.

Anahtar Kelimeler

• Çocuk obezitesi,
• ALT,
• Vitamin D,
• CRP,
• Demir

Pediatric Obesity: A Focus On Multifactorial Influences Including Iron And Hematological Parameters

Öz

Aim: To examine age-related differences in the association between vitamin D status and pediatric obesity, and to evaluate the relationship between obesity and inflammatory, hematological, and metabolic parameters. Material and Method: This retrospective cross-sectional study reviewed 8,010 pediatric medical records from January 2021 to December 2022. After applying inclusion and exclusion criteria, 1,134 children aged 10–18 years were included and classified as obese (n=482), overweight (n=155), or healthy controls (n=497). Serum 25-hydroxyvitamin D [25(OH)D] levels, complete blood count parameters, C-reactive protein (CRP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and iron-related indices were analyzed and compared between groups. Results: Gender distribution differed significantly among weight groups (χ²=60.32, p<0.001), with obesity being more prevalent in females. Children with obesity were younger than those in the overweight and healthy groups (F=21.44, p<0.001). Obesity was associated with higher white blood cell counts (F=11.49, p<0.001), elevated CRP levels (F=3.63, p<0.05), and increased ALT and AST levels (ALT: F=28.86, p<0.001; AST: F=11.76, p<0.001). Serum iron and mean corpuscular volume values were significantly lower in children with obesity (p<0.05). Mean serum vitamin D levels did not differ significantly between weight groups (F=2.94, p=0.05), and categorical vitamin D status showed no significant association with obesity (χ²=2.37, p=0.67). Conclusion: Pediatric obesity is associated with inflammatory, hematological, and hepatic alterations. In this adolescent cohort, serum vitamin D levels were not significantly associated with obesity. These findings suggest that the relationship between vitamin D status and obesity may vary by age and appear weaker during adolescence.

Anahtar Kelimeler

• Pediatric obesity
• ALT
• Vitamin D
• CRP
• iron

Kaynakça

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