Bilateral Arteria Carotis Communis Ligasyonu Sonrası Arteria Basilaris’te Gözüken Morfohistopatolojik Değişikliklere Cinsiyetin Etkisi: Deneysel Çalışma

Öz

incelmesi, uzama, kıvrılma, vasküler remodelizasyon ve anevrizmalara sebep olabilir. Biz cinsiyetin bilateral arteria carotis communis
ligasyonu sonucu oluşan histomorfolojik değişikliklerin derecesine olan etkisini araştırdık.
Materyal ve Metot: Bu çalışma 7 dişi ve 7 erkek tavşan üzerinde yapılmıştır. Hem erkek hem de dişi tavşanlardan ikisi kontrol, diğerleriyse
deney grubu olarak kullanıldı. Arteria carotis communis bifurkasyonunun hemen proksimalinden uygulanan kalıcı ligasyon, steno-oklüziv
karotis arter hastalığını tekrarlamak için yapıldı. Hayvanlar üzerinde yapılan bu çalışmanın 3. haftasında baziler arter hacmi stereolojik
yöntemlerle ölçüldü. Sonuçlar Mann-Whitney U testi ile karşılaştırıldı.
Bulgular: Baziler arterlerde büyük oranda luminal genişleme, duvar incelmesi, uzaması, kıvrılması ve doligoektatik kümelenme tespit edildi.
Baziler arterlerin ortalama hacmi erkek kontrol grubu tavşanlarında 3,65 ± 0,35 mm3, erkek deney tavşanlarında ise 4.96 ± 0.99 mm3 olarak
değerlendirildi. Baziler arterlerin ortalama hacim değerleri dişi kontrol grubu tavşanlarında 3,97 ± 0,40 mm3, dişi deney tavşanlarında ise
6,32 ± 1,13 mm3 olduğu tespit edildi. Baziler arter genişlemesi dişi tavşanlarda erkeklerden gözle görülür derecede belirgindi (p<0.01).
Sonuç: Bilateral arteria carotis communis ligasyonu, dişi tavşanlarda erkek tavşanlara göre daha belirgin luminal genişleme, duvar
incelmesi, uzama, kıvrılma ve anevrizmalara sebep oluyor.

Anahtar Kelimeler

• Bilateral arteria carotis communis ligasyonu, baziler arterler, stereolojik yöntem

Effect of Gender on Morphohistopathological changes of Basilar Arteries Following Bilateral Common Carotid artery Ligation: An Experimental Study

Öz

Aim: Steno-occlusive carotid artery disease causes increased pressure, retrograde blood flow, luminal enlargement, vascular wall
thinning, elongation, convolutions, vascular re-modelization, and aneurysm formation in basilar arteries. We investigated if gender affects
the severity of histomorphologic alterations of basilar arteries after bilateral common carotid artery ligation.
Material and Methods: This study was conducted on 7 male and 7 female rabbits. Two of both male and female rabbits were used as a
control group and the remaining were used as the study group. Permanent ligation of the common carotid arteries from just proximal of
bifurcation was performed to replicate steno-occlusive carotid artery disease. Basilar artery volumes were measured by stereological
methods after the sacrifice of the animals at the end of the 3rd week. Results were compared Mann-Witney U test between groups.
Results: Luminal enlargement, wall thinning, elongation, convolutions, and doligoectatic configurations were detected in the majority of
basilar arteries. The mean basilar arterial volume values were estimated as male rabbits were 3.65 ± 0.35 mm3 in control and 4.96 ± 0.99
mm3 in the study group. The mean basilar arterial volume values were estimated as female rabbits were 3.97 ± 0.40 mm3 in control and
6.32 ± 1.13 mm3 in the study group. The severity of basilar enlargement was significantly higher in the female rabbits compared with the
male rabbits (p < 0.01).
Conclusion: Bilateral common carotid artery ligation causes more severe luminal enlargement, wall thinning, elongation, convolution, and
aneurysm formation in female rabbits than males.
Keywords: Bilateral common carotid artery ligation (BCCAL), basilar artery (BA), stereological method

Anahtar Kelimeler

• common carotid ligation,
• basilar arteries
• stereological method

Kaynakça

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