Yaygın Anksiyete Bozukluğunda Nötrofil Lenfosit Oranı

Öz

Amaç: Yaygın anksiyete bozukluğu (YAB)’ndaki nötrofil lenfosit oranı (NLO) ve monosit lenfosit oranı (MLO) değerlerini incelemeyi amaçladık. Yöntem: Bu retrospektif çalışmada YAB tanısı alan hastaların (n=43) NLO ve MLO değerleri sağlıklı olguların (n=35) verileri ile karşılaştırıldı. Bulgular: Hasta ve sağlıklı kontrol grubu, kadınlardan oluşuyordu ve ortalama yaşları benzerdi (p=0,287). Nötrofil sayısı (p<0,001), nötrofil yüzdesi (p=0,008) ve NLO (p=0,011) hasta grubunda anlamlı olarak yüksekti. Lenfosit yüzdesi kontrol grubunda anlamlı olarak daha yüksekti (p=0,018). Monosit sayısı, lenfosit sayısı, monosit yüzdesi ve MLO gruplar arasında benzerdi (p>0,05). Sonuç: Bu çalışma, YAB’da nötrofil ilişkili parametrelerin artışını göstermesi bakımından önemlidir.

Anahtar Kelimeler

• Yaygın anksiyete bozukluğu
• nötrofil lenfosit oranı
• monosit lenfosit oranı
• hemogram
• tam kan sayımı

Neutrophil to Lymphocyte Ratio in Generalized Anxiety Disorder

Öz

Aim: We aimed to investigate neutrophil to lymphocyte ratio (NLR) and monocyte to lymphocyte ratio (MLR) values in generalized anxiety disorder (GAD). Method: In this retrospective study, NLR and MLR of patients diagnosed with GAD (n=43) were compared with the data of healthy subjects (n=35). Results: The patient and healthy control groups consisted of females and their mean ages were similar (p=0.298). Neutrophil count (p<0.001), percentage of neutrophil (p=0.008), and NLR (p=0.011) were significantly higher in the patient group. The percentage of lymphocyte was significantly higher in the control group (p=0.018). Monocyte count, lymphocyte count, percentage of monocyte, and MLR were similar between the groups (p>0.05). Conclusion: This study is important in terms of showing the increase of neutrophil related parameters in GAD.

Anahtar Kelimeler

• Generalized anxiety disorder
• neutrophil to lymphocyte ratio
• monocyte to lymphocyte ratio
• hemogram
• complete blood count

Kaynakça

1. 1. Zulfic Z, Weickert CS, Weickert TW, Liu D, Myles N, Galletly C. Neutrophil-lymphocyte ratio - a simple, accessible measure of inflammation, morbidity and prognosis in psychiatric disorders? Australas Psychiatry. 2020;1039856220908172. doi:10.1177/1039856220908172.
2. 2. Kara MZ, Örüm MH, Sekmen E. Is there a relationship between basophil, platelet-related parameters and developmental stuttering? Anadolu Psikiyatri Derg. 2020;21(2):187-94.
3. 3. Cevher-Binici N, Alşen-Güney S, İnal-Emiroğlu FN. Neutrophil-lymphocyte and platelet-lymphocyte ratios among adolescents with bipolar disorder: A preliminary study. Psychiatry Res. 2018;269:178-82.
4. 4. Arabska J, Łucka A, Magierski R, Sobów T, Wysokiński A. Neutrophil-lymphocyte ratio is increased in elderly patients with first episode depression, but not in recurrent depression. Psychiatry Res. 2018;263:35-40.
5. 5. Orum MH, Kara MZ, Egilmez OB, Kalenderoglu A. Complete blood count alterations due to the opioid use: what about the lymphocyte-related ratios, especially in monocyte to lymphocyte ratio and platelet to lymphocyte ratio?, J Immunoassay Immunochem. 2018;39(4):365-76.
6. 6. Orum MH, Kara MZ, Egilmez OB. Relationship between immune cells and alcohol dependents and controls: what about the lymphocyte-related ratios? J Immunoassay Immunochem. 2018;39(3):348-50.
7. 7. Ransing RS, Gupta N, Agrawal G, Mahapatro N. Platelet and red blood cell indices in patients with panic disorder: A receiver operating characteristic analysis. J Neurosci Rural Pract. 2020;11(2):261-6.
8. 8. Özyurt G, Binici NC. The neutrophil-lymphocyte ratio and platelet-lymphocyte ratio in adolescent obsessive-compulsive disorder: Does comorbid anxiety disorder affect inflammatory response?. Psychiatry Res. 2019;272:311-5.

9. 9. Asoglu M, Aslan M, Imre O, Kivrak Y, Akil O, Savik E, et al. Mean platelet volume and red cell distribution width levels in initial evaluation of panic disorder. Neuropsychiatr Dis Treat. 2016;12:2435-8.
10. 10. Hamzekolaei MG, Jafarisani M, Farajzadeh A, Aghayan SS, Atashi A, Yarmohammadi M, et al. Changes in mean platelet volume and hematologic indices in patients with panic disorder due to oxidative stress. Brain Behav. 2020;10(4):e01569.
11. 11. Ransing RS, Patil B, Grigo O. Mean platelet volume and platelet distribution width level in patients with panic disorder. J Neurosci Rural Pract. 2017;8(2):174-8.
12. 12. Gögçegöz Gül I, Eryilmaz G, Ozten E, Hizli Sayar G. Decreased mean platelet volume in panic disorder. Neuropsychiatr Dis Treat. 2014;10:1665-9.
13. 13. Gunduz N, Timur O, Erzincan E, Tural U. The mean platelet volume, neutrophil lymphocyte ratio, platelet lymphocyte ratio and red cell distribution width in panic disorder. Anadolu Psikiyatri Derg. 2018;19(1):5-12.
14. 14. Gurok MG, Yılmaz S, Temizkan A, Ustundag B, Atmaca M. Levels of basophils and eosinophils are elevated while lymphocytes are reduced in patients with panic disorder compared to controls: a preliminary study. Psychiat Clin Psych. 2019;29(3):315-9.
15. 15. Atmaca M, Kilic F, Koseoglu F, Ustundag B. Neutrophils are decreased in obsessive-compulsive disorder: preliminary investigation. Psychiatry Investig. 2011;8(4):362-5.
16. 16. Uzun AD, Yalın-Sapmaz Ş, Çakır B, Kandemir H. Could neutrophil-to-lymphocyte ratio be an important parameter in children and adolescents with obsessive compulsive disorder? J Clinical Psychiatry. 2020;23:101-5.
17. 17. Uçar HN, Murat D, Eray Ş. Simple peripheral markers for inflammation in drug-naive, comorbidity-free adolescents with obsessive-compulsive disorder. East J Med. 2019;24(1):23-9.
18. 18. Han-Almış B, Aksoy I. Mean platelet volume level in patients with generalized anxiety disorder. Psychiatr Clin Psychopharmacol. 2018;28(1):43-7.
19. 19. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). Arlington, VA: 2013.
20. 20. Orum MH, Kara MZ, Egilmez OB. Mean platelet volume and neutrophil to lymphocyte ratio as parameters to indicate the severity of suicide attempt. J Immunoassay Immunochem. 2018;39(6):647-59.
21. 21. Kara MZ, Orum MH, Egilmez OB. Relationship between immune cells and violent/nonviolent suicide attempts and controls: What about the lymphocyte-related ratios and neutrophil-related parameters? Kaohsiung J Med Sci. 2019;35(5):315-6.
22. 22. Özen ME, Örüm, MH, Yılmaz MB, Kalenderoğlu A. İnflamatuar biyobelirteçler açısından bipolar bozukluk tip 1 tanılı hastaların sağlıklı kontrollerle karşılaştırılması. Adıyaman Üni Sağlık Bilimleri Derg. 2019;5(1):1351-60.
23. 23. Hori H, Kim Y. Inflammation and post-traumatic stress disorder. Psychiatry Clin Neurosci. 2019;73(4):143-53.
24. 24. Manivasagam T, Arunadevi S, Essa MM, Babu CS, Borah A, Thenmozhi AJ, et al. Role of oxidative stress and antioxidants in autism. Adv Neurobiol. 2020;24:193-206.
25. 25. Egilmez OB, Orum MH, Beyazyuz E, Aydemir MÇ. Investigation of serum brain-derived neurotrophic factor (BDNF) levels in patients diagnosed with schizophrenia without antipsychotic treatment history. J Neuro Behav Sci. 2018;5(3):165-71.
26. 26. Büyükaslan H, Asoğlu M. Evaluation of mean platelet volume, red cell distributed width and neutrophil to lymphocyte ratio in conversion disorder. Neuropsychiatr Dis Treat. 2019;15:2879-84.
27. 27. Müller N. COX-2 inhibitors, aspirin, and other potential anti-inflammatory treatments for psychiatric disorders. Front Psychiatry. 2019;10:375.
28. 28. Orum MH, Kara MZ. Monocyte to lymphocyte ratio and platelet to lymphocyte ratio in opioid users and marijuana users. Dusunen Adam The Journal of Psychiatry and Neurological Sciences. 2020;2(33):139-45.
29. 29. Zahorec R. Ratio of neutrophil to lymphocyte counts—rapid and simple parameter of systemic inflammation and stress in critically ill. Bratisl Lek Listy. 2001;102:5-14.
30. 30. Wright HL, Moots RJ, Bucknall RC and Edwards SW. Neutrophil function in inflammation and inflammatory diseases. Rheumatology. 2010;49:1618-31.
31. 31. Örüm MH. Basophil count, percentage of basophil and basophil lymphocyte ratio in psychiatry practice: Current approaches and future directions. J Contemp Med. https://doi.org/10.16899/jcm.610786.
32. 32. Orum MH, Kara MZ. Platelet to lymphocyte ratio (PLR) in alcohol use disorder. J Immunoassay Immunochem. 2020;41(2):184-94.
33. 33. Yüksel RN, Ertek IE, Dikmen AU, Göka E. High neutrophil-lymphocyte ratio in schizophrenia independent of infectious and metabolic parameters. Nordic Journal of Psychiatry. 2018;72:336-40.
34. 34. Mallorquí-Bagué N, Bulbena A, Pailhez G, Garfinkel SN, Critchley HD. Mind-Body Interactions in Anxiety and Somatic Symptoms. Harv Rev Psychiatry. 2016;24(1):53-60.
35. 35. Hara KM, Aviram A, Constantino MJ, Westra HA, Antony MM. Therapist empathy, homework compliance, and outcome in cognitive behavioral therapy for generalized anxiety disorder: partitioning within- and between-therapist effects. Cogn Behav Ther. 2017;46(5):375-390.