The Role of Thiol-Disulfide Hemostasis in Predicting Renal İnjury After Coronary Artery Bypass Graft Surgery

Abstract

Aim: EInflammation andoxidative stres play an active role in renal injury that develops after open heart operations as in many diseases. There is a balance between oxidants and antioxidant defense mechanisms, and in the morbidity of cardiac surgery patients, this balance is thought to change depending on many factors.
Materials and Methods: 76 patients scheduled for coronary artery bypass graft surgery were included in the study. Demographic and operation information of the patients were recorded. In addition to routine blood parameters, blood samples were taken forthiol / disulfid hemostasis parameters. Patients who did not develop acut kidney injury (AKI) after the operation were recorded as Group 1 and those who developed register as Group 2.
Results: Postoperative AKI developed in 19 (25%) patients included in the study. When the thiol-disulfide hemostasis parameter values obtained from the blood sample taken within the first 2 hours after the introduction of intensive care after the operation of the patients, there was no difference between the two groups in terms of native thiol, total thiol, disulfide / native thiol and native thiol / total thiol values. In Group 2, disufide and disulfide / total thiol values were significantly higher (P = 0.018, P = 0.009).
Conclusion: We believe that the values of disulfide and disulfide / total thiol ratio, which are among the parameters of thiol-disulfide hemostasis, in the postoperative period may be predictors for AKI.

Keywords

• oxidative stres parameters
• thiol levels
• disulfide
• kidney injury
• cardiac surgery

Kaynakça

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