Did Pregnancy Complications Increase During The COVID-19 Pandemic Period?

Öz

Aim: This study aimed to investigate the potential increase in the pregnancy complications during the pandemic period. Materials and Methods: Data of the pregnant women who were admitted between April/May2019 and April/May2020 for stillbirth, preterm labor, term prelabor rupture of membranes (PROM), preterm premature rupture of membranes (PPROM), placental abruption, miscarriage and abortion imminens were collected from the hospital database and retrospectively analyzed. Results: During the COVID-19 pandemic period between April/May2020, 1604 deliveries occurred in our hospital. Totally 1401 deliveries had occurred in the same monthly interval of 2019. In the early pregnancy unit, 566 patients were admitted to be monitored in 2019 whereas that number is 466 in 2020. In the pandemic period, a statistically significant difference was found between 2019 and 2020 regarding the rates of admission after 22nd gestational week and admission to the Early Pregnancy Assessment Unit. Bonferroni tests were performed to determine which group of the patients generated this difference and it was determined that the rates of term PROM and miscarriage increased statistically significantly in 2020 compared with 2019. Conclusion: We concluded that the effect of COVID-19 on symptomatic and asymptomatic pregnant women will be further clarified by switching to routine screening program for pregnant women in our country. COVID-19 antibody testing is important to confirm our results in the cases with term PROM and miscarriage who are asymptomatic with respect to COVID-19.

Anahtar Kelimeler

• Asymptomatic
• Complication
• COVID-19
• Pandemic
• Pregnancy

Kaynakça

1. 1. Lu Roujian Z, Juan L, Peihua N, et al. Genomic characterization and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet (Lond, Engl). 2020;395(10224):565-574.
2. 2. WHO Director-General's remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s-remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020 access date 18.05.2020.
3. 3. Turkish Ministry of Health, Directorate General of Public Health, Covid-19 Guide. https://hsgm.saglik.gov.tr/depo/birimler/goc_sagligi/covid19/rehber/COVID-19_Rehberi20200414_eng_v4_002_14.05.2020.pdf access date 18.05.2020.
4. 4. Coronavirus disease 2019 (COVID-19): situation report, 51 https://apps.who.int/iris/handle/10665/331475 access date 18.05.2020.
5. 5. Elshafeey F, Magdi R, Hindi N, et al. A systematic scoping review of COVID-19 during pregnancy and childbirth. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2020;150(1):47-52.
6. 6. ACOG. Practice Advisory: Novel Coronavirus 2019 (COVID-19). https://www.acog.org/clinical/clinical-guidance/practice-advisory/articles/2020/03/novel-coronavirus-2019 access date 17.04.2020.
7. 7. Remuzzi A, Remuzzi G. COVID-19 and Italy: what next? Lancet (London, England). 2020;395(10231):1225-1228.
8. 8. Sutton D, Fuchs K, D'Alton M, et al. Universal Screening for SARS-CoV-2 in Women Admitted for Delivery. The New England journal of medicine. 2020;382(22):2163-2164.

9. 9. Ai T, Yang Z. Correlation of Chest CT and RT-PCR Testing for Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases. 2020;296(2):E32-e40.
10. 10. Siston AM, Rasmussen SA, Honein MA, et al. Pandemic 2009 influenza A(H1N1) virus illness among pregnant women in the United States. Jama. 2010;303(15):1517-1525.
11. 11. Conover PT, Roessmann U. Malformational complex in an infant with intrauterine influenza viral infection. Arch Pathol Lab Med. 1990;114(5):535-538.
12. 12. Schwartz DA, Dhaliwal A. Infections in pregnancy with COVID-19 and other respiratory RNA virus diseases are rarely, if ever, transmitted to the fetus: experiences with Coronaviruses, HPIV, hMPV RSV, and INFLUENZA. Arch Pathol Lab Med. 2020.
13. 13. Di Mascio D, Khalil A, Saccone G, et al. Outcome of coronavirus spectrum infections (SARS, MERS, COVID-19) during pregnancy: a systematic review and meta-analysis. Am J Obstet Gynecol MFM. 2020;2(2):100107.
14. 14. Håberg SE, Trogstad L, Gunnes N, et al. Risk of fetal death after pandemic influenza virus infection or vaccination. The New England journal of medicine. 2013;368(4):333-340.
15. 15. Huang C, Wang Y, Li X, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet (London, England). 2020;395(10223):497-506.
16. 16. Yan J, Guo J, Fan C, et al. Coronavirus disease 2019 in pregnant women: a report based on 116 cases. Am J Obstet Gynecol. 2020;223(1):111.e111-111.e114.
17. 17. Tanacan A, Erol SA, Turgay B, et al. The rate of SARS-CoV-2 positivity in asymptomatic pregnant women admitted to hospital for delivery: Experience of a pandemic center in Turkey. European journal of obstetrics, gynecology, and reproductive biology. 2020;253:31-34.
18. 18. Kumar D, Moore RM, Mercer BM, et al. The physiology of fetal membrane weakening and rupture: Insights gained from the determination of physical properties revisited. Placenta. 2016;42:59-73.