Pediatrik Popülasyonda Korpus Kallozum Morfometrisinin Değerlendirilmesi, Cinsiyetler Arasında Fark Var Mı?

Öz

Amaç: Korpus kallozum (CC) bir beyaz cevher yapısıdır ve beyin hemisferlerini birbirine bağlayan en büyük interhemisferik komissürdür. CC’nin morfolojisi doğuştan ve edinilmiş hastalıklardan, cinsiyetten, yaştan ve el seçiminden etkilenebilir. Bu çalışma CC’nin morfometrik özelliklerini yaşa ve cinsiyete göre incelemeyi amaçlamaktadır.
Materyal ve Metot: Sağlıklı pediatrik popülasyonun tüm korpus kallozum segmentlerinin kalınlığı ve CC’nin uzun ekseninin uzunluğu, septum pellusidum ve massa intermedia’nın izlenebildiği midsagittal hattan manyetik rezonans görüntüleme (MRI) ile ölçüldü. Toplam 240 katılımcı (120 erkek ve 120 kadın) dört yaş grubuna ayrıldı; 0-2 yaş grubu, 3-6 yaş grubu, 7-11 yaş grubu ve 12-17 yaş grubu ve CC’nin beş segmentinin kalınlığı (rostrum, genu, gövde, isthmus, splenium) ve CC’nin anterior-posterior uzunluğu ölçüldü.
Bulgular: Her iki cinsiyette de CC’nin uzun ekseninin uzunluğu ve CC segmentlerinin kalınlığı (rostrum hariç) yaşla birlikte anlamlı olarak artmaktaydı. Ancak cinsiyet ayrımı yapmadan tüm katılımcıları değerlendirdiğimizde CC’nin tüm segmentlerinin kalınlığının ve uzun eksen uzunluğunun yaşla birlikte istatistiksel olarak anlamlı şekilde arttığı görülmektedir.
Sonuç: Sağlıklı pediatrik popülasyondan elde edilen veriler, doğumsal ve edinsel hastalıklara bağlı olarak CC’nin anormal morfometrik değişikliklerini ayırt etmeye yardımcı olacaktır.

Anahtar Kelimeler

• Korpus Kallozum
• Manyetik Rezonans Görüntüleme
• Pediatrik Popülasyon

Evaluation of Corpus Callosum Morphometry in Pediatric Population, is there any Difference Between Genders ?

Öz

Aim: Corpus callosum (CC) is a white matter structure and it is the largest interhemispheric commissure that connects the brain hemispheres. The morphology of CC can be affected by congenital and acquired diseases, sex, age, and hand selection. This study aims to investigate morphometric features of CC by age and gender.
Material and Methods: Thickness of all corpus callosum segments and length of the long axis of the CC of the healthy pediatric population were measured via magnetic resonance imaging (MRI) from the midsagittal line where the septum pellucidum and massa intermedia can be monitored. A total of 240 participants (120 males and 120 females) were divided into four age groups; 0-2 age group, 3-6 age group, 7-11 age group, and 12-17 age group and thickness of the five segments of the CC (rostrum, genu, body, isthmus, splenium) and anterior-posterior length of the CC were measured.
Results: Thicknesses of four segments that included genu, body, isthmus, and splenium (except the rostrum) and length of the long axis of CC increased significantly with age in both genders. However, when we evaluated all participants without gender discrimination, the thickness of all segments of CC and length of the long axis are observed to increase significantly.
Conclusion: The obtained data from the healthy pediatric population will help differentiate the abnormal morphometric changes of CC due to congenital and acquired diseases.

Anahtar Kelimeler

• Corpus Callosum
• Magnetic Resonance Imaging
• Pediatric Population

Kaynakça

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