Klinik Araştırma
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The Relationship between Helicobacter Pylori and Intestinal Parasites in Patients with Peptic Ulcer

Yıl 2023, Cilt: 5 Sayı: 1, 132 - 9, 15.01.2023
https://doi.org/10.37990/medr.1183913

Öz

Aim: This study aimed to evaluate the frequency of Helicobacter pylori (H. pylori), risk factors, and co-infection with intestinal parasites in adult patients presenting gastrointestinal complaints.
Materials and Methods: The working group of the study consisted of 385 patients with gastrointestinal complaints. A questionnaire including questions aiming to canvass the socio-demographic features, lifestyles, and complaints of the patients was administered to the study population. Cellophane slide method, native-lugol, sedimentation and Modified kinyoun acid-fast methods were used for the diagnosis of parasites in stool, under microscope. The H. pylori antigen was studied in the stool sample taken for the diagnosis of H. pylori.
Results: H. pylori positivity was found to be 27.79% in the patients included in the study. 76.6% of those who are positive for H. pylori are women, and the positivity rate was found to be higher at the age of 40 and over (75.7%). The majority of patients with H. pylori positivity expressed being married (73.8%), having middle / low-income (89.7%), having a low educational background (82.2%), living in a village (55.1%), and in a nuclear family (72.2%) (p<0.001). H. pylori positivity was higher in those who used tap water (40.2%) and those who had a vegetable-based diet (75.7%) (p<0.001). The study found a statistically significant correlation between Entamoeba histoloytica and Enterobius vermicularis positivity and H. pylori positivity (p<0.05 p<0.001, respectively). The calculated odds ratio showed that H. pylori positivity was 1.19 times higher in Entamoeba histoloytica positivity and 11.27 times higher in Enterobius vermicularis positivity.
Conclusion: Larger and more comprehensive studies should be performed to understand better the epidemiology, clinical effects, treatment, and control of H. pylori co-infection. 

Destekleyen Kurum

This research was financially supported by the Scientific Project Office of Ordu University (AR-1663).

Proje Numarası

AR-1663

Teşekkür

We would like to thank Ordu University Scientific Research Projects Coordination Unit for its support for the AR-1663 project.

Kaynakça

  • 1. Seid A, Tamir Z, Kasanew B, Senbetay M. Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia. BMC Research Notes. 2018;11:1-6.
  • 2. Ugras M, Miman Ö. The prevalence of intestinal parasites in children with Helicobacter pylori gastritis evaluated retrospectively. Turkiye Parazitol Derg. 2013;37:245.
  • 3. Moreira Jr ED, Nassri VB, Santos RS, et al. Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. World J Gastroenterol. 2005;11:2759.
  • 4. Goodman KJ, Correa P, Aux HJT, et al. Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways. Am J Epidemiol. 1996;144:290-9.
  • 5. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22:283-97.
  • 6. Toroglu S, Yilmaz M, Keskin D. Entamoeba histolytica’s importance in terms of human and animal health. Duzce University Journal of Science and Technology. 2018;6:275-91.
  • 7. Önlen Güneri C, Kaya ÖM, Çelik E. Inverstigation of distribution of Enterobius vermicularis in students of primary school in Hatay. Van Medical Journal. 26:142-5.
  • 8. Mehraj V, Hatcher J, Akhtar S, et al. Prevalence and factors associated with intestinal parasitic infection among children in an urban slum of Karachi. PloS One. 2008;3:e3680.
  • 9. Başkanlığı TCSBTHSK. Dışkının mikroskobik bakısı, Tricrom boyama https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 10. Başkanlığı TCSBTHSK. Microscopic examination of feces, Condensation method https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 11. Başkanlığı TCSBTHSK. Microscopic view of stool parasitological examination. https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 12. Hanafi MI, Mohamed AM. Helicobacter pylori infection: seroprevalence and predictors among healthy individuals in Al Madinah, Saudi Arabia. J Egypt Public Health Assoc. 2013;88:40-5.
  • 13. Olokoba A, Gashau W, Bwala S, et al. Helicabacter pylori Infection in Nigerians with Dyspepsia. Ghana Med J. 2013;47:79-81.
  • 14. Sethi A, Chaudhuri M, Kelly L, Hopman W. Prevalence of Helicobacter pylori in a First Nations population in northwestern Ontario. Can Fam Physician. 2013;59:e182-e7.
  • 15. Zhu Y, Zhou X, Wu J, et al. Risk factors and prevalence of Helicobacter pylori infection in persistent high incidence area of gastric carcinoma in Yangzhong city. Gastroenterol Res Pract. 2014;2014. 16. Eusebi LH ZR, Bazzoli F. . Epidemiology of Helicobacter pylori infection. Helicobacter. 2014;19:1-5.
  • 17. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13 C-Urea breath test. BMC Public Health. 2013;13:1-12.
  • 18. Korkmaz M, Sadıç M, Koca G, et al. The Relationship of helicobacter pylori infection with demographic, socioeconomic and environmental factors: Ankara Hospital Experience. Kafkas J Med Sci. 2013;3:74–9.
  • 19. van Blankenstein M, van Vuuren AJ, Looman CW, et al. The prevalence of Helicobacter pylori infection in the Netherlands. Scand J Gastroenterol. 2013;48:794-800.
  • 20. Vilaichone R-k, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol. 2013;19:2806.
  • 21. Benajah DA, Lahbabi M, Alaoui S, et al. Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). CClin Res Hepatol Gastroenterol. 2013;37:519-26.
  • 22. Mathewos B, Moges B, Dagnew M. Seroprevalence and trend of Helicobacter pylori infection in Gondar University Hospital among dyspeptic patients, Gondar, North West Ethiopia. BMC Res Notes. 2013;6:1-4.
  • 23. Den Hollander WJ, Holster IL, den Hoed CM, et al. Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic E uropean city. JJ Gastroenterol Hepatol. 2013;28:1705-11.
  • 24. Benberin V, Bektayeva R, Karabayeva R, et al. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res. 2013;33:4595-602.
  • 25. Mana F, Vandebosch S, Deyi VM, et al. Prevalence of and risk factors for H. pylori infection in healthy children and young adults in Belgium anno 2010/2011. Acta Gastroenterol Belg. 2013;76:381-5.

Peptik Ülser Hastalarında Helicobacter pylori ile Barsak Parazitleri Arasındaki İlişki

Yıl 2023, Cilt: 5 Sayı: 1, 132 - 9, 15.01.2023
https://doi.org/10.37990/medr.1183913

Öz

Amaç: Bu çalışmanın amacı, gastrointestinal şikayetlerle başvuran erişkin hastalarda H. pylori sıklığı, risk faktörleri ve intestinal parazitlerle ko-enfeksiyonunu değerlendirmektir.
Materyal ve Metod: Gastrointestinal şikayetleri olan 385 hasta çalışmaya alınmıştır. Hastaların sosyo-demografik özelliklerine, yaşam tarzlarına ve şikayetlerine yönelik sorular içeren anket uygulanmıştır. Dışkıda parazit tanısı için Selofanlı bant yöntemi, nativ-lügol, sedimantasyon ve Modifiye kinyoun asit-fast, yöntemleri kullanılmıştır. Dışkı örnekleri mikroskopta incelenmiştir. H. pylori tanısı içinde alınan dışkı örneğinde H. pylori antijeni çalışılmıştır.
Bulgular: H.pylori pozitifliği %27.79 idi. H.pylori pozitif olanların 76.6%sı kadındı. H.pylori pozitif oranı 40 yaş ve üzerinde daha yüksekti (75.7%). H. pylori pozitifliği görülen hastaların büyük çoğunluğu evli (73.8), orta/düşük gelir düzeyine sahip (89.7%), düşük eğitim düzeyi olan (82.2%), köyde yaşayan (55.1%) ve çekirdek ailesiyle birlikte yaşamını sürdüren (72.2%) bireylerdi (p<0.001). H.pylori pozitifliği şehir şebeke suyu kullananlarda (40.2%) ve sebze ağırlıklı beslenenlerde daha yüksekti (75.7%) (p<0.001). Entamoeba histoloytica ve Enterobius vermicularis pozitifliği ile H.pylori pozitifliği arasında istatistiksel olarak önemli bir ilişki olduğu görüldü (sırasıyla p<0.05 p<0.001). Hesaplanan Odds ratio, Entamoeba histoloytica pozitifliğinde H.pylori pozitifliğinin 1,19 kat, Enterobius vermicularis pozitifliğinde H.pylori pozitifliğinin 11.27 kat daha fazla olduğunu gösterdi.
Sonuç: H pilori ile co-enfeksiyonun epidemiyolojisinin, klinik etkilerinin, tedavisinin ve kontrolünün iyi anlaşılması için daha geniş ve kapsamlı çalışmalara ihtiyaç vardır.

Proje Numarası

AR-1663

Kaynakça

  • 1. Seid A, Tamir Z, Kasanew B, Senbetay M. Co-infection of intestinal parasites and Helicobacter pylori among upper gastrointestinal symptomatic adult patients attending Mekanesalem Hospital, northeast Ethiopia. BMC Research Notes. 2018;11:1-6.
  • 2. Ugras M, Miman Ö. The prevalence of intestinal parasites in children with Helicobacter pylori gastritis evaluated retrospectively. Turkiye Parazitol Derg. 2013;37:245.
  • 3. Moreira Jr ED, Nassri VB, Santos RS, et al. Association of Helicobacter pylori infection and giardiasis: results from a study of surrogate markers for fecal exposure among children. World J Gastroenterol. 2005;11:2759.
  • 4. Goodman KJ, Correa P, Aux HJT, et al. Helicobacter pylori infection in the Colombian Andes: a population-based study of transmission pathways. Am J Epidemiol. 1996;144:290-9.
  • 5. Brown LM. Helicobacter pylori: epidemiology and routes of transmission. Epidemiol Rev. 2000;22:283-97.
  • 6. Toroglu S, Yilmaz M, Keskin D. Entamoeba histolytica’s importance in terms of human and animal health. Duzce University Journal of Science and Technology. 2018;6:275-91.
  • 7. Önlen Güneri C, Kaya ÖM, Çelik E. Inverstigation of distribution of Enterobius vermicularis in students of primary school in Hatay. Van Medical Journal. 26:142-5.
  • 8. Mehraj V, Hatcher J, Akhtar S, et al. Prevalence and factors associated with intestinal parasitic infection among children in an urban slum of Karachi. PloS One. 2008;3:e3680.
  • 9. Başkanlığı TCSBTHSK. Dışkının mikroskobik bakısı, Tricrom boyama https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 10. Başkanlığı TCSBTHSK. Microscopic examination of feces, Condensation method https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 11. Başkanlığı TCSBTHSK. Microscopic view of stool parasitological examination. https://hsgm.saglik.gov.tr/depo/birimler/Mikrobiyoloji_Referans_Laboratuvarlari_ve_Biyolojik_Urunler_DB/rehberler/UMS_LabTaniRehberi_Cilt_3.pdf2014.
  • 12. Hanafi MI, Mohamed AM. Helicobacter pylori infection: seroprevalence and predictors among healthy individuals in Al Madinah, Saudi Arabia. J Egypt Public Health Assoc. 2013;88:40-5.
  • 13. Olokoba A, Gashau W, Bwala S, et al. Helicabacter pylori Infection in Nigerians with Dyspepsia. Ghana Med J. 2013;47:79-81.
  • 14. Sethi A, Chaudhuri M, Kelly L, Hopman W. Prevalence of Helicobacter pylori in a First Nations population in northwestern Ontario. Can Fam Physician. 2013;59:e182-e7.
  • 15. Zhu Y, Zhou X, Wu J, et al. Risk factors and prevalence of Helicobacter pylori infection in persistent high incidence area of gastric carcinoma in Yangzhong city. Gastroenterol Res Pract. 2014;2014. 16. Eusebi LH ZR, Bazzoli F. . Epidemiology of Helicobacter pylori infection. Helicobacter. 2014;19:1-5.
  • 17. Ozaydin N, Turkyilmaz SA, Cali S. Prevalence and risk factors of helicobacter pylori in Turkey: a nationally-representative, cross-sectional, screening with the 13 C-Urea breath test. BMC Public Health. 2013;13:1-12.
  • 18. Korkmaz M, Sadıç M, Koca G, et al. The Relationship of helicobacter pylori infection with demographic, socioeconomic and environmental factors: Ankara Hospital Experience. Kafkas J Med Sci. 2013;3:74–9.
  • 19. van Blankenstein M, van Vuuren AJ, Looman CW, et al. The prevalence of Helicobacter pylori infection in the Netherlands. Scand J Gastroenterol. 2013;48:794-800.
  • 20. Vilaichone R-k, Mahachai V, Shiota S, et al. Extremely high prevalence of Helicobacter pylori infection in Bhutan. World J Gastroenterol. 2013;19:2806.
  • 21. Benajah DA, Lahbabi M, Alaoui S, et al. Prevalence of Helicobacter pylori and its recurrence after successful eradication in a developing nation (Morocco). CClin Res Hepatol Gastroenterol. 2013;37:519-26.
  • 22. Mathewos B, Moges B, Dagnew M. Seroprevalence and trend of Helicobacter pylori infection in Gondar University Hospital among dyspeptic patients, Gondar, North West Ethiopia. BMC Res Notes. 2013;6:1-4.
  • 23. Den Hollander WJ, Holster IL, den Hoed CM, et al. Ethnicity is a strong predictor for Helicobacter pylori infection in young women in a multi‐ethnic E uropean city. JJ Gastroenterol Hepatol. 2013;28:1705-11.
  • 24. Benberin V, Bektayeva R, Karabayeva R, et al. Prevalence of H. pylori infection and atrophic gastritis among symptomatic and dyspeptic adults in Kazakhstan. A hospital-based screening study using a panel of serum biomarkers. Anticancer Res. 2013;33:4595-602.
  • 25. Mana F, Vandebosch S, Deyi VM, et al. Prevalence of and risk factors for H. pylori infection in healthy children and young adults in Belgium anno 2010/2011. Acta Gastroenterol Belg. 2013;76:381-5.
Toplam 24 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri
Bölüm Özgün Makaleler
Yazarlar

Yasemin Kaya 0000-0001-7360-8090

Ülkü Karaman 0000-0001-7027-1613

Cemil Çolak 0000-0001-5406-098X

Hamza Çınar 0000-0003-1748-1392

Ahmet Karataş 0000-0001-9095-6054

Neval Berrin Arserim 0000-0002-7097-0091

Gamze Yolalan 0000-0002-3125-9379

Şermin Top 0000-0003-2684-7798

Proje Numarası AR-1663
Erken Görünüm Tarihi 15 Ocak 2023
Yayımlanma Tarihi 15 Ocak 2023
Kabul Tarihi 7 Kasım 2022
Yayımlandığı Sayı Yıl 2023 Cilt: 5 Sayı: 1

Kaynak Göster

AMA Kaya Y, Karaman Ü, Çolak C, Çınar H, Karataş A, Arserim NB, Yolalan G, Top Ş. The Relationship between Helicobacter Pylori and Intestinal Parasites in Patients with Peptic Ulcer. Med Records. Ocak 2023;5(1):132-9. doi:10.37990/medr.1183913

 Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Turkey

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Turkey

E-mail: medrecsjournal@gmail.com

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