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Evaluation of the Relationship Between Vitamin D Deficiency and Epicondylitis

Year 2025, Volume: 7 Issue: 1, 12 - 15
https://doi.org/10.37990/medr.1510250

Abstract

Aim: Though there is strong evidence connecting vitamin D deficiency to several health problems, such as diabetes mellitus, infections, autoimmune and endocrine diseases, cancer, and increased cardiovascular mortality and morbidity, studies examining the connection between vitamin D deficiency and epicondylitis are rare. The purpose of this study was to see if low vitamin D levels and epicondylitis were linked.
Material and Method: A total of 410 patients presented with the complaint of elbow pain and whose 25-hydroxycholecalciferol (25(OH)D) levels were evaluated. The files of 205 patients diagnosed with medial or lateral epicondylitis by physical examination and 205 controls not considered to have medial or lateral epicondylitis were reviewed retrospectively. Vitamin D levels were measured using 25(OH)D levels.
Results: Vitamin D levels were considerably lower (p<.001) in the epicondylitis group.
Conclusion: It is unclear precisely what causes epicondylitis, but the fact that our study's participants had much lower vitamin D levels raises the possibility that low vitamin D is one of the causes. More research is needed to understand how vitamin D levels may contribute to the etiology of epicondylitis in general.

Ethical Statement

The necessary permissions for this study were obtained from the Erzurum City Hospital Clinical Research Ethics Committee on November 24, 2022, with the decision numbered 2022/18-173.

References

  • Akgün K, Palamar D. Üst ekstremite ağrıları. In: Oğuz H, Çakırbay H, Yanık B, eds. Tıbbi Rehabilitasyon. 3rd edition, İstanbul: Nobel Tıp Kitabevleri; 2015:913-29.
  • Shiri R, Viikari-Juntura E. Lateral and medial epicondylitis: role of occupational factors. Best Pract Res Clin Rheumatol. 2011;25:43-57.
  • Sivrioğlu K. Dirsek Ağrısı. In: Özcan O, İrdesel J, Sivrioğlu K, eds. Kas İskelet Sistemi Ağrıları. Bursa: Nobel & Güneş Tıp Kitabevi; 2005:258-72.
  • Birtane M. Bel Ağrısı Nedenleri ve Muayenesi. In: Beyazova M, Kutsal YG, eds. Fiziksel Tıp ve Rehabilitasyon. 3rd edition, Ankara: Güneş Tıp Kitabevleri; 2016:1637-48.
  • Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic Proc. 2010:85:752-7.
  • Pludowski P, Holick MF, Grant WB, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125-35.
  • Giustina A, Adler RA, Binkley N, et al. Controversies in Vitamin D: Summary Statement From an International Conference. J Clin Endocrinol Metab. 2019;104:234-40.
  • Holick MF. Vitamin D deficiency. N Eng J Med. 2007;357:266-81.
  • Hyppönen E, Läärä E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-3.
  • Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174-80.
  • Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79:362-71. Erratum in: Am J Clin Nutr. 2004;79:890.
  • Chen S, Glenn DJ, Ni W, et al. Expression of the vitamin D receptor is increased in the hypertrophic heart. Hypertension. 2008;52:1106-12.
  • Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int. 2006;17:1133-40.
  • Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010;6:550-61.
  • Wacker M, Holick MF. Vitamin D-Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5:111-48.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
  • Thankam FG, Dilisio MF, Gross RM, Agrawal DK. Collagen I: A kingpin for rotator cuff tendon pathology. Am J Transl Res. 2018;10:3291-309. Erratum in: J Clin Endocrinol Metab. 2011;96:3908.
  • Thankam FG, Dilisio MF, Agrawal DK. Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. Mol Cell Biochem. 2016;417:17-33.
  • Quigley AS, Bancelin S, Deska-Gauthier D, et al. In tendons, differing physiological requirements lead to functionally distinct nanostructures. Sci Rep. 2018;8:4409.
  • Min K, Lee JM, Kim MJ, et al. Restoration of cellular proliferation and characteristics of human tenocytes by vitamin D. J Orthop Res. 2019;37:2241-8.
  • Chen K, Li P, Zhao H, et al. Effects of tumor necrosis factor inhibitor on stress-shielded tendons. Orthopedics. 2017;40:49-55.
  • Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspesific musculoskeletal pain. Mayo Clin Pro. 2003;78:1463-70.
  • Yaka H, Başbuğ V, Tekin AA, Özer M. Evaluation of the relationship between lateral epicondylitis and Vitamin D. J Dis Relat Surg. 2022;33:414-8.
Year 2025, Volume: 7 Issue: 1, 12 - 15
https://doi.org/10.37990/medr.1510250

Abstract

References

  • Akgün K, Palamar D. Üst ekstremite ağrıları. In: Oğuz H, Çakırbay H, Yanık B, eds. Tıbbi Rehabilitasyon. 3rd edition, İstanbul: Nobel Tıp Kitabevleri; 2015:913-29.
  • Shiri R, Viikari-Juntura E. Lateral and medial epicondylitis: role of occupational factors. Best Pract Res Clin Rheumatol. 2011;25:43-57.
  • Sivrioğlu K. Dirsek Ağrısı. In: Özcan O, İrdesel J, Sivrioğlu K, eds. Kas İskelet Sistemi Ağrıları. Bursa: Nobel & Güneş Tıp Kitabevi; 2005:258-72.
  • Birtane M. Bel Ağrısı Nedenleri ve Muayenesi. In: Beyazova M, Kutsal YG, eds. Fiziksel Tıp ve Rehabilitasyon. 3rd edition, Ankara: Güneş Tıp Kitabevleri; 2016:1637-48.
  • Kennel KA, Drake MT, Hurley DL. Vitamin D deficiency in adults: when to test and how to treat. Mayo Clinic Proc. 2010:85:752-7.
  • Pludowski P, Holick MF, Grant WB, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125-35.
  • Giustina A, Adler RA, Binkley N, et al. Controversies in Vitamin D: Summary Statement From an International Conference. J Clin Endocrinol Metab. 2019;104:234-40.
  • Holick MF. Vitamin D deficiency. N Eng J Med. 2007;357:266-81.
  • Hyppönen E, Läärä E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358:1500-3.
  • Giovannucci E, Liu Y, Hollis BW, Rimm EB. 25-hydroxyvitamin D and risk of myocardial infarction in men: a prospective study. Arch Intern Med. 2008;168:1174-80.
  • Holick MF. Vitamin D: importance in the prevention of cancers, type 1 diabetes, heart disease, and osteoporosis. Am J Clin Nutr. 2004;79:362-71. Erratum in: Am J Clin Nutr. 2004;79:890.
  • Chen S, Glenn DJ, Ni W, et al. Expression of the vitamin D receptor is increased in the hypertrophic heart. Hypertension. 2008;52:1106-12.
  • Erkal MZ, Wilde J, Bilgin Y, et al. High prevalence of vitamin D deficiency, secondary hyperparathyroidism and generalized bone pain in Turkish immigrants in Germany: identification of risk factors. Osteoporos Int. 2006;17:1133-40.
  • Arabi A, El Rassi R, El-Hajj Fuleihan G. Hypovitaminosis D in developing countries-prevalence, risk factors and outcomes. Nat Rev Endocrinol. 2010;6:550-61.
  • Wacker M, Holick MF. Vitamin D-Effects on skeletal and extraskeletal health and the need for supplementation. Nutrients. 2013;5:111-48.
  • Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1911-30.
  • Thankam FG, Dilisio MF, Gross RM, Agrawal DK. Collagen I: A kingpin for rotator cuff tendon pathology. Am J Transl Res. 2018;10:3291-309. Erratum in: J Clin Endocrinol Metab. 2011;96:3908.
  • Thankam FG, Dilisio MF, Agrawal DK. Immunobiological factors aggravating the fatty infiltration on tendons and muscles in rotator cuff lesions. Mol Cell Biochem. 2016;417:17-33.
  • Quigley AS, Bancelin S, Deska-Gauthier D, et al. In tendons, differing physiological requirements lead to functionally distinct nanostructures. Sci Rep. 2018;8:4409.
  • Min K, Lee JM, Kim MJ, et al. Restoration of cellular proliferation and characteristics of human tenocytes by vitamin D. J Orthop Res. 2019;37:2241-8.
  • Chen K, Li P, Zhao H, et al. Effects of tumor necrosis factor inhibitor on stress-shielded tendons. Orthopedics. 2017;40:49-55.
  • Plotnikoff GA, Quigley JM. Prevalence of severe hypovitaminosis D in patients with persistent, nonspesific musculoskeletal pain. Mayo Clin Pro. 2003;78:1463-70.
  • Yaka H, Başbuğ V, Tekin AA, Özer M. Evaluation of the relationship between lateral epicondylitis and Vitamin D. J Dis Relat Surg. 2022;33:414-8.
There are 23 citations in total.

Details

Primary Language English
Subjects Physical Medicine and Rehabilitation
Journal Section Original Articles
Authors

Buminhan Seferoğlu 0000-0002-5636-8387

Nurmuhammet Taş 0000-0002-8033-4208

Publication Date
Submission Date July 4, 2024
Acceptance Date November 13, 2024
Published in Issue Year 2025 Volume: 7 Issue: 1

Cite

AMA Seferoğlu B, Taş N. Evaluation of the Relationship Between Vitamin D Deficiency and Epicondylitis. Med Records. 7(1):12-15. doi:10.37990/medr.1510250

17741

Chief Editors

Assoc. Prof. Zülal Öner
Address: İzmir Bakırçay University, Department of Anatomy, İzmir, Türkiye

Assoc. Prof. Deniz Şenol
Address: Düzce University, Department of Anatomy, Düzce, Türkiye

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