The effect of royal jelly supplementation for three months on bone markers in postmenopausal osteoporotic women

Yıl 2021, Cilt: 21 Sayı: 1, 59 - 68, 15.07.2021

Bünyamin AYDIN Müge ATAR Özgür PİRGON

Öz

Bu çalışmada postmenopozal dönemdeki osteoporozu olan kadınlarda 3 aylık arı sütü (royal jelly) kullanımının kemik yapım ve yıkım belirteçlerini değerlendirerek kemik üzerindeki etkilerinin değerlendirilmesi amaçlanmıştır. Postmenopozal seksen kadın katılımcı, rastgele olarak arısütü verilenler (n=50)ve verilmeyenler (n=30) olarak ikiye ayrılmıştır. Arısütü alan gruba üç ay boyunca içerisinde 1 gram arısütü olan 100 mL sıvı verilmiştir. Kontrol grubuna ise yine 100 mL sıvı olacak şekilde plasebo verilmiştir. Kemik yapım belirteci olan N-terminal propeptit tip 1 kollajen (P1NP) ve kemik yıkım belirteci olan C-terminal telopeptit tip1 kollajen (CTX), sklerostin seviyeleri 0. ve 3. Ayda olmak üzere her iki grupta incelenmiştir. Sonuç olarak yaş, menopoz süresi, vücut kitle indeksi ve lomber vertebra kemik mineral dansitometri T skoru açısından benzer iki grupta kemik yapım ve yıkım beliteçleri açısından fark saptanmamıştır. Östrojenik etkisi yüksek olan arı sütünün 3 aylık süre boyunca kullanımı ile osteoporoz üzerine etkisi gösterilememiştir.

Anahtar Kelimeler

Arı sütü, osteoporoz, postmenopoz, östrojen

Kaynakça

• [1] COSMAN F., DE BEUR SJ., LEBOFF MS., LEWİECKİ EM., TANNER B., RANDALL S., LİNDSAY R.; (2014) National Osteoporosis Foundation. Clinician's Guide to Prevention and Treatment of Osteoporosis. Osteoporos Int. Oct;25(10):2359-81.
• [2] CAMACHO, P. M., PETAK, S. M., BİNKLEY, N., CLARKE, B. L., HARRİS, S. T., et al. (2016). AMERICAN ASSOCIATION OF CLINICAL ENDOCRINOLOGISTS AND AMERICAN COLLEGE OF ENDOCRINOLOGY CLINICAL PRACTICE GUIDELINES FOR THE DIAGNOSIS AND TREATMENT OF POSTMENOPAUSAL OSTEOPOROSIS-20 Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 22(Suppl 4), 1–42.
• [3] TİMİNS J. K. (2004). Current issues in hormone replacement therapy. New Jersey medicine : the journal of the Medical Society of New Jersey, 101(3), 21–27.
• [4] BRANCA F. (2003). Dietary phyto-oestrogens and bone health. The Proceedings of the Nutrition Society, 62(4), 877–887.
• [5] FRATİNİ, F., CİLİA, G., MANCİNİ, S., & FELİCİOLİ, A. (2016). Royal Jelly: An ancient remedy with remarkable antibacterial properties. Microbiological research, 192, 130–141.
• [6] RAMADAN, M.F., AL-GHAMDİ, A. (2012). “Bioactive compounds and health-promoting properties of royal jelly: A review”. Journal of Functional Foods, 4: 39-52.
• [7] KUSHİMA K., HASEGAWA N., OGAWA E. (1973) Effects of royal jelly on autonomic imbalance in menopausal women. World Obstetric Gynecology, 25:439–43
• [8] KUNUGİ, H., & MOHAMMED ALİ, A. (2019). Royal Jelly and Its Components Promote Healthy Aging and Longevity: From Animal Models to Humans. International journal of molecular sciences, 20(19), 4662.
• [9] KOCOT, J., KİEŁCZYKOWSKA, M., LUCHOWSKA-KOCOT, D., KURZEPA, J., & MUSİK, I. (2018). Antioxidant Potential of Propolis, Bee Pollen, and Royal Jelly: Possible Medical Application. Oxidative medicine and cellular longevity, 2018, 7074209.
• [10] MİSHİMA, S., SUZUKİ, K. M., ISOHAMA, Y., KURATSU, N., ARAKİ, Y., INOUE, M., & MİYATA, T. (2005). Royal jelly has estrogenic effects in vitro and in vivo. Journal of ethnopharmacology, 101(1-3), 215–220.
• [11] MOUTSATSOU, P., PAPOUTSİ, Z., KASSİ, E., HELDRİNG, N., ZHAO, C., TSİAPARA, A., MELLİOU, E., CHROUSOS, G. P., CHİNOU, I., KARSHİKOFF, A., NİLSSON, L., & DAHLMAN-WRİGHT, K. (2010). Fatty acids derived from royal jelly are modulators of estrogen receptor functions. PloS one, 5(12), e15594.
• [12] SPEROFF, L., KENEMANS, P., & BURGER, H. G. (2005). Practical guidelines for postmenopausal hormone therapy. Maturitas, 51(1), 4–7.
• [13] NASH, L. A., & WARD, W. E. (2017). Tea and bone health: Findings from human studies, potential mechanisms, and identification of knowledge gaps. Critical reviews in food science and nutrition, 57(8), 1603–1617.
• [14] HWANG, Y. H., HA, H., KİM, R., CHO, C. W., SONG, Y. R., HONG, H. D., & KİM, T. (2018). Anti-Osteoporotic Effects of Polysaccharides Isolated from Persimmon Leaves via Osteoclastogenesis Inhibition. Nutrients, 10(7), 901.
• [15] LAMBERT, M., HU, L. M., & JEPPESEN, P. B. (2017). A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resorption in peri- and postmenopausal women. The American journal of clinical nutrition, 106(3), 801–811.
• [16] MİYATA T. (2007). Pharmacological basis of traditional medicines and health supplements as curatives. Journal of pharmacological sciences, 103(2), 127–131.
• [17] GUERRA, J. M., HANES, M. A., RASA, C., LOGANATHAN, N., INNİS-WHİTEHOUSE, W., GUTİERREZ, E., NAİR, S., & BANU, J. (2019). Modulation of bone turnover by Cissus quadrangularis after ovariectomy in rats. Journal of bone and mineral metabolism, 37(5), 780–795.
• [18] KAFADAR, I. H., GÜNEY, A., TÜRK, C. Y., ONER, M., & SİLİCİ, S. (2012). Royal jelly and bee pollen decrease bone loss due to osteoporosis in an oophorectomized rat model. Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery, 23(2), 100–105.
• [19] HİDAKA, S., OKAMOTO, Y., UCHİYAMA, S., NAKATSUMA, A., HASHİMOTO, K., OHNİSHİ, S. T., & YAMAGUCHİ, M. (2006). Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evidence-based complementary and alternative medicine : eCAM, 3(3), 339–348.
• [20] NARİTA, Y., NOMURA, J., OHTA, S., INOH, Y., SUZUKİ, K. M., ARAKİ, Y., OKADA, S., MATSUMOTO, I., ISOHAMA, Y., ABE, K., MİYATA, T., & MİSHİMA, S. (2006). Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell lines. Bioscience, biotechnology, and biochemistry, 70(10), 2508–2514.
• [21] KOYA-MİYATA, S., OKAMOTO, I., USHİO, S., IWAKİ, K., IKEDA, M., & KURİMOTO, M. (2004). Identification of a collagen production-promoting factor from an extract of royal jelly and its possible mechanism. Bioscience, biotechnology, and biochemistry, 68(4), 767–773.
• [22] LİNDBERG, M. K., MOVÉRARE, S., ERİKSSON, A. L., SKRTİC, S., GAO, H., DAHLMAN-WRİGHT, K., GUSTAFSSON, J. A., & OHLSSON, C. (2002). Identification of estrogen-regulated genes of potential importance for the regulation of trabecular bone mineral density. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 17(12), 2183–2195.
• [23] LAMBRİNOUDAKİ, I., AUGOULEA, A., RİZOS, D., POLİTİ, M., TSOLTOS, N., MOROS, M., CHİNOU, I., GRAİKOU, K., KOUSKOUNİ, E., KAMBANİ, S., PANOULİS, K., & MOUTSATSOU, P. (2016). Greek-origin royal jelly improves the lipid profile of postmenopausal women. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 32(10), 835–839.
• [24] SHİMİZU S, MATSUSHİTA H, MİNAMİ A, KANAZAWA H, SUZUKİ T, WATANABE K, WAKATSUKİ A. Royal jelly does not prevent bone loss but improves bone strength in ovariectomized rats. Climacteric. 2018 Dec;21(6):601-606.
• [25] GUO, H., SAİGA, A., SATO, M., MİYAZAWA, I., SHİBATA, M., TAKAHATA, Y., & MORİMATSU, F. (2007). Royal jelly supplementation improves lipoprotein metabolism in humans. Journal of nutritional science and vitaminology, 53(4), 345–348.
• [26] MORİTA, H., IKEDA, T., KAJİTA, K., FUJİOKA, K., MORİ, I., OKADA, H., UNO, Y., & ISHİZUKA, T. (2012). Effect of royal jelly ingestion for six months on healthy volunteers. Nutrition journal, 11, 77.