Deneysel Gastrik Ülser Modelinde Propolis ve Arı Ekmeğinin Koruyucu Etkisi

Yıl 2021, Cilt: 21 Sayı: 1, 18 - 28, 15.07.2021

Züleyha Doğanyiğit , Arda Uner , Aslı Okan Oflamaz , Sibel Silici

Öz

Amaç: Mide ülseri (gastrik ülser) üst sindirim sisteminin en yaygın hastalığıdır. Hastalığın patofizyolojisi çevresel etmenler ve non-stereoid anti-inflamatuar ilaçlarla ilişkilendirilmektedir. Bu faktörlerin mide mukoza bariyerini zayıflatması ve asit salınımını arttırması ile mide epitelinde hasar meydana gelmektedir. Medikal tedavi yaklaşımları yaygın olarak kullanılmakla beraber yan etkiler görülmektedir. Propolis ve arı ekmeği bal arılarının ürünlerinden elde edilen doğal bileşiklerdir. Yapılan çalışmalarda bu bileşiklerin antioksidan, antimikrobiyal ve anti-inflamatuar etkilere sahip olduğu gösterilmiştir. Bu çalışmada indomethacin ile indüklenen gastrik ülser hayvan modelinde propolis ve arı ekmeğinin terapötik etkilerinin araştırılması amaçlanmıştır.
Gereç ve Yöntemler: Çalışmada 48 adet Wistar cinsi erkek ratlar kullanılmıştır. Kontrol grubu, İndometazin uygulanan ülser grubu, düşük ve yüksek doz arı ekmeği (perga) grupları, düşük ve yüksek doz propolis içeren gruplar olmak üzere 6 rastgele grup oluşturulmuştur. Enjeksiyonlar ve tedavi uygulamaları sonrasında hayvanların mide dokuları histolojik olarak ve kan örnekleri biyokimyasal olarak incelenmiştir.
Bulgular: Elde edilen bulgulara göre propolis ve arı ekmeğinin, indomethacin ile oluşturulan mide ülserinde epitel hasarını önleyerek kontrol grubu ile benzer histopatolojik yapı oluşturduğu gözlemlendi (p<0.05).
Sonuç: Bu veriler propolis ve arı ekmeğinin gastrik ülser tedavisinde umut vadeden etkilere sahip olduğunu doğrulamaktadır.

Anahtar Kelimeler

Arı ekmeği, Propolis, Mide, Ülser, Histoloji

Protective Effect of Propolis and Bee Bread in Experimental Gastric Ulcer Model

Öz

Objective: Gastric ulcer is the most common disease of the upper digestive system. The pathophysiology of the disease is associated with environmental factors and non-steroidal anti-inflammatory drugs. These factors weaken the gastric mucosal barrier and increase acid secretion, causing damage to the gastric epithelium. Although medical treatment approaches are widely used, side effects are seen. Propolis and bee bread are natural compounds obtained from the products of honeybees. Studies have shown that these compounds have antioxidant, antimicrobial, and anti-inflammatory effects. In this study, it was aimed to investigate the therapeutic effects of propolis and bee bread in an animal model of gastric ulcer induced by indomethacin.
Material and Methods: 48 male Wistar rats were used in the study. Six random groups were formed as the control group, the indomethacin-treated ulcer group, the low and high-dose bee bread (Perga) groups, the low and high-dose propolis groups. After injections and treatment applications, stomach tissues of animals were examined histologically and blood samples biochemically.
Results: According to the obtained findings, propolis and bee bread prevented epithelial damage in gastric ulcer induced by indomethacin and formed a histopathological structure similar to the control group (p <0.05).
Conclusion: These data indicate that propolis and bee bread have protective and therapeutic effects in the treatment of gastric ulcers.

Anahtar Kelimeler

Bee bread, Propolis, Stomach, Ulcer, Histology

Kaynakça

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