Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging

Pınar Pelin Özcan; Zehra Pınar Koç; Gökçe Yavan; Mustafa Musa Dirlik

Görüntü Sunumu

Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging

Yıl 2022, Cilt: 2 Sayı: 1, 12 - 16, 15.04.2022

Pınar Pelin Özcan Zehra Pınar Koç Gökçe Yavan Mustafa Musa Dirlik

Öz

Von Hippel–Lindau disease (VHL), also known as Von Hippel–Lindau syndrome, is a rare genetic disorder with multisystem involvement (1). Imaging plays an important role in the evaluation of cancer patients. In recent years, much attention has been focused on 68Ga-PSMA PET-CT. We hereby, report the rare case of a Von Hippel Lindau Syndrome with renal cell carcinoma, pancreas cystadenoma, hemangioblastoma and pancreatic NET demonstrated on both Ga-68 PSMA and FDG PET-CT imaging.

Anahtar Kelimeler

68 Ga PSMA PET-CT, FDG PET-CT, Von Hippel Lindau Syndrome

Kaynakça

1. Von Hippel-Lindau disease, Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17
2. Lindsay, Kenneth W; Ian Bone; Robin Callander; J. van Gijn (1991). Neurology and Neurosurgery Illustrated. United States: Churchill Livingstone. ISBN 978-0-443-04345-1
3. Frantzen, Carlijn; Links, Thera P.; Giles, Rachel H. (21 June 2012). "Von Hippel-Lindau Syndrome". Von Hippel-Lindau Disease. GeneReviews at NCBI. University of Washington, Seattle. Retrieved 30 March 2013
4. Maher ER; Glenn GM; Walther M; et al. (June 2011). "von Hippel-Lindau disease: a clinical and scientific review". European Journal of Human Genetics. 19 (6): 617–23
5. Friedrich, CA (December 1, 1999). "Von Hippel-Lindau syndrome. A pleomorphic condition". Cancer. 86 (11 Suppl): 2478–82
6. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
7. Ambrosini V, Campana D, Allegri V, et al. 68Ga-DOTANOC PET/CT detects somatostatin receptors expression in von Hippel-Lindau cerebellar disease. Clin. Nucl. Med. 2011; 36:64–65.
8. Oh JR, Kulkarni H, Carreras C, et al. Ga-68 Somatostatin Receptor PET/CT in von Hippel-Lindau Disease. Nucl. Med. Mol. Imaging. 2012; 46:129–133
9. Papadakis G.Z., Millo C, Sadowski SM, et. al. Epididymal cystadenomas in von Hippel-Lindau disease showing increased activity on 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October ; 41(10): 781–782
10. Sizdahkhani S, Michael J. Feldman MJ.,Martin G. Piazza MG., et. al. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Scientific Reports | 7:40822 | DOI: 10.1038/srep40822
11. Papadakis G.Z., Millo C, Sadowski SM, et. al. Endolymphatic sac tumor showing increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October; 41(10): 783–784
12. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
13. Wood CG, Stromberg LJ, Harmath CB, et al. CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 2015; 35:125–141.
14. Hofman MS, Lau WF, Hicks RJ. Somatostatin Receptor Imaging with 68Ga-DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 2015; 35:500–516
15. Papadakis GZ, Bagci U, Sadowski SM, et al. Ectopic ACTH and CRH co-secreting tumor localized by 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2015; 40:576–578
16. Papadakis G.Z., Millo C, Sadowski SM, et. al. Kidney tumor in a von Hippel-Lindau (VHL) patient with intensely increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 December; 41(12): 970–971

Yıl 2022, Cilt: 2 Sayı: 1, 12 - 16, 15.04.2022

Pınar Pelin Özcan Zehra Pınar Koç Gökçe Yavan Mustafa Musa Dirlik

Öz

Kaynakça

1. Von Hippel-Lindau disease, Genetic and Rare Diseases Information Center (GARD) – an NCATS Program". rarediseases.info.nih.gov. Retrieved 2018-04-17
2. Lindsay, Kenneth W; Ian Bone; Robin Callander; J. van Gijn (1991). Neurology and Neurosurgery Illustrated. United States: Churchill Livingstone. ISBN 978-0-443-04345-1
3. Frantzen, Carlijn; Links, Thera P.; Giles, Rachel H. (21 June 2012). "Von Hippel-Lindau Syndrome". Von Hippel-Lindau Disease. GeneReviews at NCBI. University of Washington, Seattle. Retrieved 30 March 2013
4. Maher ER; Glenn GM; Walther M; et al. (June 2011). "von Hippel-Lindau disease: a clinical and scientific review". European Journal of Human Genetics. 19 (6): 617–23
5. Friedrich, CA (December 1, 1999). "Von Hippel-Lindau syndrome. A pleomorphic condition". Cancer. 86 (11 Suppl): 2478–82
6. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
7. Ambrosini V, Campana D, Allegri V, et al. 68Ga-DOTANOC PET/CT detects somatostatin receptors expression in von Hippel-Lindau cerebellar disease. Clin. Nucl. Med. 2011; 36:64–65.
8. Oh JR, Kulkarni H, Carreras C, et al. Ga-68 Somatostatin Receptor PET/CT in von Hippel-Lindau Disease. Nucl. Med. Mol. Imaging. 2012; 46:129–133
9. Papadakis G.Z., Millo C, Sadowski SM, et. al. Epididymal cystadenomas in von Hippel-Lindau disease showing increased activity on 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October ; 41(10): 781–782
10. Sizdahkhani S, Michael J. Feldman MJ.,Martin G. Piazza MG., et. al. Somatostatin receptor expression on von Hippel-Lindau-associated hemangioblastomas offers novel therapeutic target. Scientific Reports | 7:40822 | DOI: 10.1038/srep40822
11. Papadakis G.Z., Millo C, Sadowski SM, et. al. Endolymphatic sac tumor showing increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 October; 41(10): 783–784
12. Leung RS, Biswas SV, Duncan M, et al. Imaging features of von Hippel-Lindau disease. Radiographics. 2008; 28:65–67
13. Wood CG, Stromberg LJ, Harmath CB, et al. CT and MR imaging for evaluation of cystic renal lesions and diseases. Radiographics. 2015; 35:125–141.
14. Hofman MS, Lau WF, Hicks RJ. Somatostatin Receptor Imaging with 68Ga-DOTATATE PET/CT: clinical utility, normal patterns, pearls, and pitfalls in interpretation. Radiographics. 2015; 35:500–516
15. Papadakis GZ, Bagci U, Sadowski SM, et al. Ectopic ACTH and CRH co-secreting tumor localized by 68Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2015; 40:576–578
16. Papadakis G.Z., Millo C, Sadowski SM, et. al. Kidney tumor in a von Hippel-Lindau (VHL) patient with intensely increased activity on 68 Ga-DOTA-TATE PET/CT. Clin Nucl Med. 2016 December; 41(12): 970–971

Toplam 16 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	İngilizce
Konular	Onkoloji ve Karsinogenez
Bölüm	Case Reports
Yazarlar	Pınar Pelin Özcan Bu kişi benim 0000-0003-0147-2678 Zehra Pınar Koç Bu kişi benim 0000-0002-3274-5790 Gökçe Yavan Bu kişi benim 0000-0002-7332-6293 Mustafa Musa Dirlik Bu kişi benim 0000-0002-5326-2149
Yayımlanma Tarihi	15 Nisan 2022
Yayımlandığı Sayı	Yıl 2022 Cilt: 2 Sayı: 1

Kaynak Göster

APA	Özcan, P. P., Koç, Z. P., Yavan, G., Dirlik, M. M. (2022). Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging, 2(1), 12-16.
AMA	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. Nisan 2022;2(1):12-16.
Chicago	Özcan, Pınar Pelin, Zehra Pınar Koç, Gökçe Yavan, ve Mustafa Musa Dirlik. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging 2, sy. 1 (Nisan 2022): 12-16.
EndNote	Özcan PP, Koç ZP, Yavan G, Dirlik MM (01 Nisan 2022) Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging 2 1 12–16.
IEEE	P. P. Özcan, Z. P. Koç, G. Yavan, ve M. M. Dirlik, “Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”, Molecular Oncologic Imaging, c. 2, sy. 1, ss. 12–16, 2022.
ISNAD	Özcan, Pınar Pelin vd. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging 2/1 (Nisan 2022), 12-16.
JAMA	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. 2022;2:12–16.
MLA	Özcan, Pınar Pelin vd. “Von Hippel Lindau Syndrome With Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging”. Molecular Oncologic Imaging, c. 2, sy. 1, 2022, ss. 12-16.
Vancouver	Özcan PP, Koç ZP, Yavan G, Dirlik MM. Von Hippel Lindau Syndrome with Renal Cell Carcinoma, Pancreas Serous Cystadenoma, Hemangioblastoma and NET Demonstrated on Ga-68 DOTATATE PET-CT and FDG PET-CT Imaging. Molecular Oncologic Imaging. 2022;2(1):12-6.