Adverse effects and nonadherence with mood stabilizers

Öz

Similar to other long-term clinical conditions nonadherence to medications is common in bipolar disorder. It is often under-recognized in clinical practice and greatly under-researched topic in academic psychiatry. Nonadherence to mood stabilizers is in part due to the adverse effects and it is more likely due to certain adverse effects such as weight gain, tremor, and cognitive impairment. Practicing psychiatrists can potentially reduce the nonadherence by vigorous attempts to identify, discuss, and ameliorate these adverse effects.

Anahtar Kelimeler

• adverse effects, nonadherence, mood stabilizers

Kaynakça

1. Goodwin FK, Jamison KR. Manic-Depressive Illness, 2nd Ed, 2007. p855. Cade JFJ. Lithium salts in the treatment of psychotic excitement. Med J Aust 1949;2:349-52.
2. Suppes T, Baldessarini RJ, Faedda GL, Tondo L, Tohen M. Discontinuation of maintenance treatment in bipolar disorder: risks and implications. Harv Rev Psychiatry 1993;1:131-44.
3. Scott J, Pope M. Self-reported adherence to treatment with mood stabilizers, Plasma levels and psychiatric hospitalization. Am J Psychiatry 2002;159:1927-9.
4. Adverse effects and nonadherence with mood stabilizers Maj M, Pirozzi R, Magliano L. Nonresponse to reinstituted lithium prophylaxis in previously responsive bipolar patients: prevalence and predictors. Am J Psychiatry 1995;152:1810-1.
5. Schou M. The combat of non-compliance during prophylactic lithium treatment. Acta Psychiatr Scand 1997;95:361-3.
6. Lingam R, Scott J. Treatment non-adherence in affective disorders. Acta Psychiatr Scand 2002;105:164-72.
7. Perlick DA, Rosenheck RA, Kaczynski R, Kozma L. Medication nonadherence in bipolar disorder: A patient-centered review of research findings. Clinical Approaches in Bipolar Disorders 2004;3:56-64.
8. Johnson RE, McFarland BH. Lithium use and discontinuation in a health maintenance organization. Am J Psychiatry 1996;153:993-1000.

9. Perlis RH, Ostacher MJ, Miklowitz DJ, Hay A, Nierenberg AA, Thase ME, Sachs GS. Clinical features associated with poor pharmacologic adherence in bipolar disorder: results from the STEP-BD study. J Clin Psychiatry 2010;71:296-303.
10. Jónsdóttir H, Opjordsmoen S, Birkenaes AB, Simonsen C, Engh JA, Ringen PA,Vaskinn A, Friis S, Sundet K, Andreassen OA. Predictors of medication adherence in patients with schizophrenia and bipolar disorder. Acta Psychiatr Scand 2012. Epub ahead of print PMID: 22900964.
11. Sajatovic M, Levin J, Fuentes-Casiano E, Cassidy KA, Tatsuoka C, Jenkins JH. Illness experience and reasons for nonadherence among individuals with bipolar disorder who are poorly adherent with medication. Compr Psychiatry 2011;52:280-7.
12. Perlick DA, Rosenheck RA, Kaczynski R, Kozma L. Medication nonadherence in bipolar disorder: A patient-centered review of research findings. Clinical Approaches in Bipolar Disorders 2004;3:56-64.
13. Bech P, Vendsborg PB, Rafaelsen OJ. Lithium maintenance treatment of manic-melancholic patients: its role in the daily routine. Acta Psychiatr Scand 1976;53:70-81.
14. Maj M, Pirozzi R, Magliano L, Bartoli L. Long-term outcome of lithium prophylaxis in bipolar disorder: a 5-year prospective study of 402 patients at a lithium clinic. Am J Psychiatry 1998;155:30-5.
15. Scott J, Pope M. Nonadherence with mood stabilizers: prevalence and predictors. J Clin Psychiatry 2002;63:384-390.
16. Baldessarini RJ, Perry R, Pike J. Factors associated with treatment nonadherence among US bipolar disorder patients. Hum Psychopharmacol 2008;23:95-105.