Pharmacotherapy of child and adolescent depression: a review

Abstract

Child and adolescent depression (CAD) is a frequent disorder, which may have a recurring and chronic course and, as a result may cause significant morbidity and mortality. Currently, antidepressant medications, cognitive behavioral therapy (CBT), and interpersonal therapy (IPT) are the treatment options whose efficacies have been proven in the treatment of CAD. Here, pharmacotherapy of CAD will be reviewed and priority will be given to prospective, methodologically more reliable and comparable studies, published in the past ten years. Studies on selective serotonin reuptake inhibitors and other medications, along with those comparing or combining medications to behavioral treatments will be summarized. Furthermore, suggestions regarding the treatment of CAD with and without comorbidities and possible side effects will be evaluated.

Keywords

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Çocuk ve ergenlerde depresyonun ilaçla tedavisi: Bir gözden geçirme

Öz

Çocuk ve ergenlik dönemi depresyonu (ÇED) sık, tekrarlayıcı ve kronik bir seyir izleyebilen bir bozukluk olup ciddi morbidite ve mortalite ile sonuçlanabilmektedir. Günümüzde ÇED tedavisinde antidepresan ilaçlar, bilişsel davranışçı terapi (BDT) ve kişiler arası terapi (KAT) etkinliği gösterilmiş tedavi seçenekleridir. Bu gözden geçirmede ÇED’in ilaçla tedavisi gözden geçirilecek ve son on yılda basılmış, ileri dönük ve yöntemsel olarak daha güvenilir ve kıyaslanabilir çalışmalara öncelik verilecektir. Seçici serotonin gerialım engelleyicileri ve diğer antidepresanlarla yapılan çalışmaların yanı sıra, ilaç tedavilerinin davranışçı tedaviler ile karşılaştırıldığı ya da birlikte kullanıldığı çalışmalar özetlenecektir. Ayrıca ÇED’in tek başına ve ekhastalıklarla birlikte bulunduğu durumlardaki tedavisiyle ilgili öneriler sunulacak ve ilaç tedavisi ile görülebilen yan etkiler değerlendirilecektir.

Anahtar Kelimeler

• Depresyon, çocuk, ergen, ilaçla tedavi, bilişsel davranışçı terapi

Kaynakça

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