Eating disorders and bipolar disorders comorbidity

Abstract

Recent data indicate bipolar disorders (BPD) often co-occurs with eating disorders (ED), but comorbidity of BPD and EDs remains relatively unexplained and unexamined. We reviewed studies addressing comorbidity of EDs in BPD and studies BPD in patients with EDs. The results of the clinical studies indicate that patients with BPD have higher rates of eating disorders compared with the general population. Rates of lifetime BPD in eating disorders are variable but higher than rates of BPD in the general population. Diagnostic, prognostic and treatment implications of these findings are discussed.

Keywords

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Yeme bozuklukları ve iki uçlu mizaç bozuklukları ekhastalığı

Öz

İki Uçlu Mizaç Bozuklukları’nın (İUMB) Yeme Bozuklukları (YB) ile yüksek oranda birlikte görüldüğünü bildiren çalışmalar yapılmıştır; fakat İUMB ile YB ekhastalığı nisbeten az çalışılmış ve tam olarak anlaşılmamış bir konudur. İki uçlu mizaç bozukluklu hastalarda yeme bozuklukları ve yeme bozukluklarında iki uçlu bozukluk ekhastalığı ile ilgili çalışmaları gözden geçirdik. Klinik çalışmaların sonuçlarına göre İUMB olan hastalarda toplumda görülen oranlardan daha yüksek oranlarda YB saptanmıştır. YB’de İUMB görülme oranları değişken olmakla birlikte genel toplumda görülen orandan daha yüksek çıkmıştır. Bu bulguların teşhiş, prognoz ve tedavi açısından önemi ve yansımaları tartışılmıştır.

Anahtar Kelimeler

• İki uçlu bozukluk, yeme bozuklukları, depresyon, ekhastalık

Kaynakça

1. Treasure J, Claudino AM, Zucker N. Eating disorders The Lancet. 2010;375:583–593.
2. Fairburn CM, Harrison PJ. Eating disorders. Lancet. 2003;361:407– 16.
3. Spindler A, Milos G. Links between eating disorder symptom severity and psychiatric comorbidity. Eating Behaviors. 2007;8:364- 373.
4. Herzog DB, Greenwood DN, Dorer DJ, Flores AT, Ekeblad ER, Richards A, Blais MA, Keller MB. Mortality in Eating Disorders: A descriptive study. Int J Eat Disord. 2000;28:20-26.
5. McElroy SL, Altshuler LL, Suppes T, Keck PE, Frye MA, Denicoff KD, Nolen WA, Kupka RW, Leverich GS, Rochussen JR, Rush AJ, Post RM. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001;158:420-426.
6. Bauer MS, Altshuler L, Evans DR, Beresford T, Williford WO, Hauger R. Prevalance and distinct correlates of anxiety, substance, and combined comorbidity in a multi-site public sector sample with bipolar disorder. Journal of Affective Disorder. 2005;85:301- 315.
7. Krishnan KR. Psychiatric and medical comorbidities of bipolar disorder. Psychosom Med. 2005;67:1-8.
8. Wildes JE, Marcus MD, Fagiolini A. Prevalence and correlates of eating disorder co-morbidity in patients with bipolar disorder. Psychiatry Res. 2008;161:51-58.

9. McElroy SL, Frye MA, Hellemann G, Altshuler L, Leverich GS, Suppes T, Keck PE, Nolen WA, Kupka R, Post RM. Prevalence and correlates of eating disorders in 875 patients with bipolar disorder. J Affect Disord. 2011;128:191-8.
10. McElroy SL, Kotwal R, Keck PE Jr, Akiskal HS. Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations? J Affect Disord. 2005;86:107-27.
11. Kawa I, Carter JD, Joyce PR, Doughty CJ, Frampton CM, Wells JE, Walsh AE, Olds RJ. Gender differences in bipolar disorder: age of onset, course, comorbidity and symptom presentation. Bipolar Disord. 2005;7:119-125.
12. Fornaro M, Perugi G, Gabrielli F, Prestia D, Mattei C, Vinciguerra V, Fornaro P. Lifetime co-morbidity with different subtypes of eating disorders in 148 females with bipolar disorders. J Affect Disord. 2010;121:147-51.
13. Outi M, Melartin TK, Suominen K, Heikki JR. Differences in axis I and II comorbidity between bipolar I ve II disorders and major depressive disorder. J Clin psychiatry. 2006;67:584-593.
14. Lam RW, Lee SK, Tam EM, Grewal BA, Yatham LN. An open trial of light therapy for women with seasonal affective disorder and comorbid bulimia nervosa. J Clin Psychiatry. 2001;62:164-168.
15. Hudson JI, Hiripi E, Pope HG Jr, Kessler RC. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication. Biol Psychiatry. 2007;61:348-58.
16. Perugi G, Toni C, Passino MCS, Akiskal KK, Kaprinis S, Akiskal HS. Bulimia nervosa in atypical depression: The mediating role of cyclothymic temperament. Journal of Affective Disorders. 2006;92:91-97.
17. Milos GF, Spindler AM, Buddeberg C, Crameri A. ve ark. Axes I and axes II comorbidity and treatment experiences in eating disorder subjects. Psychother Psychosom. 2003;72:276-285.
18. Pearlstein, T. Eating disorders and co-morbidity. Archives of Women s Mental Health. 2002;4:67-78.
19. Herzog DB, Keller MB, Sacks NR, Yeh CJ, Lavori PW. Psychiatric comorbidity in treatment-seeking anorexics and bulimics. J Am Acad Child Adolesc Psychiatry. 1992;31:810-18.
20. Blinder, BJ, Cumella EJ, Sanathara VA. Psychiatric Comorbidities of Female Inpatients With Eating Disorders. Psychosomatic Medicine. 2006;68: 454-462.
21. McElroy SL, Kotwal R, Keck PE. Comorbidity of eating disorders with bipolar disorder and treatment implications. Bipolar Disorders. 2006;8:686-695.
22. Brewerton TD, Lydiard RB, Herzog DB, Brotman AW, O’Neil PM, Ballenger JC. Comorbidity of axis I psychiatric disorders in bulimia nervosa. J Clin Psychiatry. 1995;56:77-80.
23. Lunde AV, Fasmer OB, Akiskal KK, Akiskal HS, Oedegaard KJ. The relationship of bulimia and anorexia nervosa with bipolar disorder and its temperamental foundations. Journal of Affective disorders. 2009;115: 309-314.
24. Lewinsohn PM, Shankman SA, Gau JM. The prevalence and comorbidity of subthreshold psychiatric conditions. Psychol Med. 2004;34:613-622.
25. Wamboldt FS, Kaslow NJ, Swift WJ, Ritzholds M. Short-term course of depressive symptoms in patients with eating disorders. Am J Psychiatry. 1987;144:362-364.
26. Katz JL. Eating disorder and affective disorder: relatives or merely chance acquaintances? Comprehensive Psychiatry. 1987;28:220- 228.
27. Altshuler KZ, Weiner MF. Anorexia and depression: a dissenting view. Am J Psychiatry. 1985;142:328-332.
28. Laessle RJ, Kittl S, Fitcher MM, Wittchen HU, Pirke KM. Major affective disorder in anorexia nervosa and bulimiya. Br J Psychiatry. 1987;151:785-789.
29. Silverstone PH. Low self-esteem in eating disordered patients in the absence of depression. Psychological Reports. 1990;67:276-8.
30. Devlin MJ, Walsh T. Eating disorders and depression. Psychiatric Annals. 1989;19:473-476.
31. Singh JB, Zarate CA. Pharmacological treatment of psychiatric comorbidity in bipolar disorder: a review of controlled trials. Bipolar Disorders. 2006;8; 696-709.
32. Gross HA, Ebert MH, Faden VB, Goldberg SC, Nee LE, Kaye WH. A double-blind controlled trial of lithium carbonate in primary anorexia nervosa. J Clin Psychopharmacol. 1981;1:376-381.
33. Hsu LKG, Clement L, Santhouse R, Ju ES. Treatment of bulimia nervosa with lithium carbonate. A controlled study. J Nerv Ment Dis. 1991;179:351-355.
34. Kaplan AS, GarŞnkel PE, Darby PL, Garner DM. Carbamazepine in the treatment of bulimia. Am J Psychiatry. 1983;140:1225-1226.
35. Herridge PL, Pope HG Jr. Treatment of bulimia and rapid cycling bipolar disorder with sodium valproate. J Clin Psychopharmacol. 1985;5:229-230.
36. Brewerton TD, Shannon M. Possible clozapine exacerbation of bulimia nervosa. Am J Psychiatry. 1992;149:1408–1409.
37. Paquet V, Strul J, Servais L, Pelc L, Fossion P. Sleep-related eating disorder induced by olanzapine. J Clin Psychiatry. 2002;63:597.
38. Theisen FM, Linden A, Konig IR, Martin M, Remschmidt H, Hebebrand J. Spectrum of binge eating symptomatology in patients treated with clozapine and olanzapine. J Neural Transm. 2003;110:111-121.
39. McElroy SL, Arnold LM, Shapira NA, Keck PE, Rosenthal NR, Kamin M, Hudson JI. Topiramate in the treatment of binge eating disorder associated with obesity: a randomized, placebo- controlled trial. Am J Psychiatry 2003;160:255-261.
40. Nickel C, Tritt K, Muehlbacher M, Pedrosa GilF, Mitterlehner FO, Kaplan P, Lahmann C, Leiberich PK, Krawczyk J, Kettler C, Rother WK, Loew TH, Nickel MK. Topiramate treatment in bulimia nervosa patients: a randomized, double-blind, placebo controlled trial. Int J Eat Disord. 2005; 38:295-300.
41. McElroy SL, Kotwal R, Hudson JI, Nelson EB, Keck PE. Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial. J Clin Psychiatry. 2004; 65; 50-56.