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İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular

Yıl 2013, Cilt: 3 Sayı: 5, 0 - 0, 01.05.2013

Öz

s of the Speakers / Konuşmacı leri

Kaynakça

  • Herken H, Erdal ME, Aynacioğlu AS, Barlas O, Çatalouk O, Esgi K, Brokmoller J, Kaiser R. Frequency of the 17-bp variable number of tandem repeat polymorphism in Turkish Schizophrenic patients. Schizohr Res 2002;58:99-100.
  • Detera-Wadleigh SD, Badner JA, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger JI, Gershon ES. A high denstiy genome scan detects evidence for a bipolar disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 proc natl acad sici USA.1999;96:5604-9.
  • Ewald H, Degn B, Mors O, Kruse TA. Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatr Genet,1998;8:131-40
  • Adams LJ, Mitchell PB, Fielder SL, Rosso A, Donald JA, Schofield PR. A susceptibility locus for bipolar affective disorder on chromosome 4q35. Am J hum Genet 1998;62:1084-91.
  • Kelsoe JR, Sadovnick AD, Kristbjarnarson H., Bergesch P, MroczkowskiParker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet.1996;67:533-40.
  • Ginns EI, Ott j, Egaland JA, Allen CR., Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Fals KN, Keith TP, Paul SM. A genome- wide search for chromosomal loci linked to bipolar affective disorder in the old order amish, Nat Genet, 1996;12:431-5.
  • Ewal H, Mors O, Flint T, Koed K, Eiberg H, Kruse TA. A possible locus for mainic depressive illness on chromosome 16p13, Psychiatr Genet, 1995;5:71-81.
  • Berettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberder JI, Gershon ES, chormosome 18 DNA markers and manic depressive illness evidence for a susceptibiliy gene, Proc Natl Acad Sci USA, 1994;91:5918-21.
  • Straub RE, Lehner T, Luo Y, Loth JE, Shao W, sharpe L, Alexander JR, Das K, Simon R, Fieve RR. A possible vulneralability locus for bipolar affective disorder on chromosome 21q22.3, Nat Genet, 1994;8: 291-296.
  • Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K, Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, Reich T, Stine OC, Mcmahon F, Depaula JR, Meyers D, Detera-Wadleigh S, Goldin LR, Gershon ES, Blehar MC, Nurnberger JI. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3,5,15,16,17,and 22, Am J Med Genet 1997;74:238-46.
  • Radhakrishna U, Senol S, Herken H, Gucuyener K, Gehrig C, Blouin JL, Akarsu NA, Antonarakis SE. An apparently dominant bipolar affectice disorders locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree, Eur J Hum Genet, 2001;9:39-44.
  • Herken H. Depresyonun etyolojisinde genetik kanıtlar. Klinik Psikiyatri Dergisi, Ek sayı 2002;4:5-10.
  • O’Donovan M, Jones I, Craddock N. Anticipation and repeat expansion in bipolar disorder Am J Med Genet C Semin Med Genet. 2003;15;123:10-7.
  • McMahon FJ, Stine OC, Meyers DA, Simpson SG, DePaulo JR. Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet, 1995;56:1277-86.
  • Borglum AD, Kirov G, Craddock N, Mors O, Muir W, Murray V, McKee I, Collier DA, Ewald H, Owen MJ, Blackwood D, Kruse TA. Possible parentof-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet, 2003;117:18-22.
  • Seifuddin F, Mahon PB, Judy J, Pirooznia M, Jancic D, Taylor J, Goes FS, Potash JB, Zandi PP. Meta-Analysis of Genetic Association Studies on Bipolar Disorder. Am J Med Genet Part B 2012.159B:508-518.
  • Meltzer H: Serotonergic dysfunction in depression. Br J Psychiatry Suppl 1989; 8:25-31.
  • Lucas JJ, Hen R: New players in the 5-HT receptor field: genes and knockouts. Trends Pharmacol Sci 1995; 16:246-252.
  • Gershon ES, Martinez M, Goldin LR, Gejman PV: Genetic mapping of common diseases: the challenges of manic-depressive, illness and schizophrenia. Trends Genet 1990; 6: 282-287.
  • Gutierrez B, Arranz M, Fananas L, Valles V, Guillamat R, van Os J, Collier D. 5HT2A receptor gene and bipolar affective, disorder (letter). Lancet 1995; 346:9
  • Gutierrez B, Fananas L, Arranz M, Valles V, Guillamat R, van Os J, Collier D: Allelic association analysis of the 5HT2C receptor gene in bipolar affective disorder. Neurosci Lett 1996; 212:65-67.
  • Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD. Polymorphism in serotonin transporter, gene associated with susceptibility to major depression. Lancet 1996; 347:731-733.
  • Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, Allilaire JF, Feingold J, Mallet J, Malafosse A: Association, between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry 1998; 55:33-37.
  • Angela Heiden, Petra Schüssler, Ulrike Itzlinger, Friedrich Leisch, Joachim Scharfetter, Christian Gebhardt, Karoline Fuchs, Matthäus Willeit, Linda Nilsson, Ellenore Miller-Reiter, Thomas Stompe, Kurt Meszaros, Werner Sieghart, Kurt Hornik, Siegfried Kasper, Harald N. Aschauer, Association Studies of Candidate Genes in Bipolar Disorders Neuropsychobiology 2000;42:18-21.
  • Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996; 6: 243–250.
  • Syvanen A-C, Tilgmann C, Rinne J, Ulmanen I. Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and Parkinsonian patients in Finland. Pharmacogenetics 1997; 7: 65-71.
  • Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF. Association of codon 108/158 catechol-Omethyltransferase gene polymorphism with the psychiatric manifestations of velo-cardiofacial syndrome. Am J Med Genet 1996; 67:468-472.
  • Kirov G, Murphy KC, Arranz MJ, Jones I, McCandles F, Kunugi H Murray RM, McGuffin P, Collier DA, Owen MJ, Craddock N. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Mol Psychiatry 1998; 3: 342–345.
  • Papolos DR, Veit S, Faedda GL, Saito T, Lachman HM. Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamineO-methyltransferase allele. Mol Psychiatry 1998; 3:346–349.
  • Strouss R, Bark N, Volavka J, Parsia SS, Lachman HM. Association of COMT codon 158 polymorphism aggressive and antisocial behavior in schizophrenia. Psychiatr Res 1997; 69: 71–77.
  • Lachman HM, Nolan K, Mohr P, Saito T, Volavka J. Association between COMT genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 1998; 155: 835–837.
  • Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J Gogos JA. Genotype determining low catechol-O-methyltransferase act as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94: 4571–4575.
  • Ohara K, Nagai M, Suzuki Y. Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression, Neuroreport, 1998;11;9:1305-8.
  • Savas HA, Erdal ME, Yumru M, Ozen ME, Herken H. İki uçlu bozuklukta katekol-O-metil trasnferaz enzim geni polimorfizimi: cinsiyetin etkisi, 41. Ulusal psikiyatri kognresi 1-5 Eylül 2005.
  • Qian W, Homma M, Itagaki F, Tachikawa H, Kawanishi Y, Mizukami K, Asada T, Inomata S, Honda K, Ohkohchi N, Kohda Y. MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression. Biol Pharm Bull. 2006;29:2446-50.
  • Turgut G, Kurt E, Sengul C, Alatas G, Kursunluoglu R, Oral T, Turgut S, Herken H. Association of MDR1 C3435T polymorphism with bipolar mdisorder in patients treated with valporic acid, Mol Biol Rep. 2009;36:495-9.
  • Barrett TB, Emberton JE, Nievergelt CM, Liang SG, Hauger RL, Eskin E, Schork NJ, Kelsoe JR. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. Psychiatr Genet. 2007;17:315-22.
  • Cataloluk O, Nacak M. Savas HA, Tutkun H, Zoroglu SS, Herken H, Barlas Ö, Arslan A. Angiotesin Converting Enzyme Gene In Turkish Bipolar Affective Disorders Patients. Psychiatry, Neurology and Brain Research, 2003;10:129-132.
  • Özen ME, Erdal ME, Savaş HA, Yumru M, Herken H. İki uçlu bozuklukta cinsiyetler arası genetik bir farklılık: Triptofan hidroksilaz polimorfizmi. Poster bildiri. 41. Ulusal Psikiyatri Kongresi 15-20 Kasım Palandöken Erzurum 2005.
  • Mundo E, Walker M, Cate T, Macciardi F, Kennedy JL. The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings.Arch Gen Psychiatry 2001;58:539-44.
  • Craddock N, O’Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.Schizophr Bull. 2006;32:9-16.
  • Breen G, Prata D, Osborne S, Munro J, Li T, Staddon S, Sainz D, Kerwin R, St. Clair D, Collier D. Association of the Dysbindin Gene With Bipolar Affective Disorder, Am J Psychiatry 2006; 163:1636-1638.
  • Green EK, Raybould R, Macgregor S, Gordon-Smith K, Heron J, Hyde S, Grozeva D, Hamshere M, Williams N, Owen MJ, O’Donovan MC, Jones L, Jones I, Kirov G, Craddock N. Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder, Arch Gen Psychiatry. 2005;62:642-648.
  • Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;69:428-433.
  • Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer JS, Sobel E, Juvonen H, Arajärvi R, Partonen T, Suvisaari J, Lönnqvist J, Meyer J, Peltonen L. Chromosome 1 loci in Finnish schizophrenia families. Hum. Mol. Genet. 2001;10:1611–1617.
  • Ekelund J, Hennah W, Hiekkalinna T, Parker A, Meyer J, Lönnqvist J, Peltonen L. Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry. 2004;9:1037-41.
  • Macgregor S, Visscher PM, Knott SA, Thomson P, Porteous DJ, Millar JK, Devon RS, Blackwood D, Muir WJ. A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry. 2004; 9:1083–1090.
  • Hamshere ML, Bennett P, Williams N, Segurado R, Cardno A, Norton N, Lambert D, Williams H, Kirov G, Corvin A, Holmans P, Jones L, Jones I, Gill M, O’Donovan MC, Owen MJ, Craddock N. Genome-wide linkage scan in schizoaffective disorder: Significant evidence for linkage (LOD=3.54) at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19q13. Archives of General Psychiatry. 2005;62:1081–1088.
  • Sklar P, Gabriel SB, McInnis MG, et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry. 2002;7:579–593.
  • Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL. The brainderived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet. 2002;71:651–655.
  • Geller B, Badner JA, Tillman R, et al. Linkage disequilibrium of the brainderived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry. 2004;161:1698–1700.
  • Demiryurek S, Savas HA, Igci M, Herken H, Gorucu S, Kara AF, Selek S, Oguzkan S, Bulbul F, Arslan A, Demiryurek AT. Association between the 196G > A (VAL66 MET) and -1360C > T (C-270T) polymorphisms of the brain-derived neurotrophic factor gene and bipolar disorder. Neurology
  • Psychıatry and Brain Research. 2006;13:125-130.
  • Green EK, Raybould R, Macgregor S, Hyde S, Young AH, O’Donovan MC, Owen MJ, Kirov G, Jones L, Jones I, Craddock N. Genetic variation at brain-derived neurotrophic factor (BDNF) is associated with rapid cycling in aUKbipolar disorder case-control sample of over 3000 individuals. Br J Psychiatry. 2006;188:21-5.
  • Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry. 2005;10:208–212.
  • Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmäl C, Höfels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, Nöthen MM, Cichon S. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry. 2005;58:307–314.
  • Szekeres G, Juhasz A, Rimanoczy A, Keri S, Janka Z. The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res, 2003;65:15-18.
  • Treutlein J, Rietschel M. Genome-wide association studies of alcohol dependence and substance use disorders. Curr Psychiatry Rep. 2011;13:147-55.
  • Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI Jr, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, Kwan P, Wienker TF, Daly M, Dudbridge F, Holmans PA, Lin D, Burmeister M, Greenwood TA, Hamshere ML, Muglia P, Smith EN, Zandi PP, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Bloss CS, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Schulze TG, Berrettini W, Lohoff FW, Potash JB, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Breuer R, Meier S, Strohmaier J, Witt SH, Tozzi F, Farmer A, McGuffin P, Strauss J, Xu W, Kennedy JL, Vincent JB, Matthews K, Day R, Ferreira MA, O’Dushlaine C, Perlis R, Raychaudhuri S, Ruderfer D, Hyoun PL, Smoller JW, Li J, Absher D, Thompson RC, Meng FG, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Watson SJ, Myers RM, Akil H, Boehnke M, Chambert K, Moran J, Scolnick E, Djurovic S, Melle I, Morken G, Gill M, Morris D, Quinn E, Mühleisen TW, Degenhardt FA, Mattheisen M, Schumacher J, Maier W, Steffens M, Propping P, Nöthen MM, Anjorin A, Bass N, Gurling H, Kandaswamy R, Lawrence J, McGhee K, McIntosh A, McLean AW, Muir WJ, Pickard BS, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Jones IR, Kirov G, Moskvina V, Nikolov I, O’Donovan MC, Owen MJ, Collier DA, Elkin A, Williamson R, Young AH, Ferrier IN, Stefansson K, Stefansson H, Thornorgeirsson T, Steinberg S, Gustafsson O, Bergen SE, Nimgaonkar V, Hultman C, Landén M, Lichtenstein P, Sullivan P, Schalling M, Osby U, Backlund L, Frisén L, Langstrom N, Jamain S, Leboyer M, Etain B, Bellivier F, Petursson H, Sigur Sson E, Müller-Mysok B, Lucae S, Schwarz M, Schofield PR, Martin N, Montgomery GW, Lathrop M, Oskarsson H, Bauer M, Wright A, Mitchell PB, Hautzinger M, Reif A, Kelsoe JR, Purcell SM. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Largescale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011;43:977-83. doi: 1038/ng.943.
  • Campos-de-Sousa S, Guindalini C, Tondo L, et al. Nuclear receptor reverb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. J Biol Rhythms 2010; 25:132–137.
  • Szczepankiewicz A, Skibinska M, Suwalska A, et al. No association of three GRIN2B polymorphisms with lithium response in bipolar patients. Pharmacol Rep 2009; 61:448–452.
  • Perlis RH, Adams DH, Fijal B, et al. Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression. J Clin Psychiatry 2010; 71:599–605.

İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular

Yıl 2013, Cilt: 3 Sayı: 5, 0 - 0, 01.05.2013

Öz

Son yıllarda, psikiyatri alanındaki genetik çalışmalarve temel bilimlerdeki moleküler genetik ilerlemeler giderek hız kazanmaktadır. Klinik genetik çalışmalar göstermiştir ki, genetik bilgiler sadece iki uçlu bozukluğun etyolojisine değil, tedaviye yanıt ve ilaç yan etkilerini öngörmeye yönelik imkan ve fırsatlar sağlayabilme potansiyeline de sahiptir. Bu durum, hastalığın patofizyolojisini anlamakta büyük bir etkiye sahip olup patogenezinde rol oynayan genetik ve çevresel etmenler arasındaki etkileşimi araştırmak için önemli fırsatlar sunmaktadır. Bu gözden geçirme yazısında, iki uçlu bozukluğun mutasyonlar, kromozom bölgeleri ve genetiği ile tanı ve tedavisine yönelik yapılmış çalışmalar gözden geçirilmiştir.

Kaynakça

  • Herken H, Erdal ME, Aynacioğlu AS, Barlas O, Çatalouk O, Esgi K, Brokmoller J, Kaiser R. Frequency of the 17-bp variable number of tandem repeat polymorphism in Turkish Schizophrenic patients. Schizohr Res 2002;58:99-100.
  • Detera-Wadleigh SD, Badner JA, Yoshikawa T, Goldin LR, Turner G, Rollins DY, Moses T, Sanders AR, Karkera JD, Esterling LE, Zeng J, Ferraro TN, Guroff JJ, Kazuba D, Maxwell ME, Nurnberger JI, Gershon ES. A high denstiy genome scan detects evidence for a bipolar disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2 proc natl acad sici USA.1999;96:5604-9.
  • Ewald H, Degn B, Mors O, Kruse TA. Significant linkage between bipolar affective disorder and chromosome 12q24. Psychiatr Genet,1998;8:131-40
  • Adams LJ, Mitchell PB, Fielder SL, Rosso A, Donald JA, Schofield PR. A susceptibility locus for bipolar affective disorder on chromosome 4q35. Am J hum Genet 1998;62:1084-91.
  • Kelsoe JR, Sadovnick AD, Kristbjarnarson H., Bergesch P, MroczkowskiParker Z, Drennan M, Rapaport MH, Flodman P, Spence MA, Remick RA. Possible locus for bipolar disorder near the dopamine transporter on chromosome 5. Am J Med Genet.1996;67:533-40.
  • Ginns EI, Ott j, Egaland JA, Allen CR., Fann CS, Pauls DL, Weissenbachoff J, Carulli JP, Fals KN, Keith TP, Paul SM. A genome- wide search for chromosomal loci linked to bipolar affective disorder in the old order amish, Nat Genet, 1996;12:431-5.
  • Ewal H, Mors O, Flint T, Koed K, Eiberg H, Kruse TA. A possible locus for mainic depressive illness on chromosome 16p13, Psychiatr Genet, 1995;5:71-81.
  • Berettini WH, Ferraro TN, Goldin LR, Weeks DE, Detera-Wadleigh S, Nurnberder JI, Gershon ES, chormosome 18 DNA markers and manic depressive illness evidence for a susceptibiliy gene, Proc Natl Acad Sci USA, 1994;91:5918-21.
  • Straub RE, Lehner T, Luo Y, Loth JE, Shao W, sharpe L, Alexander JR, Das K, Simon R, Fieve RR. A possible vulneralability locus for bipolar affective disorder on chromosome 21q22.3, Nat Genet, 1994;8: 291-296.
  • Edenberg HJ, Foroud T, Conneally PM, Sorbel JJ, Carr K, Crose C, Willig C, Zhao J, Miller M, Bowman E, Mayeda A, Rau NL, Smiley C, Rice JP, Goate A, Reich T, Stine OC, Mcmahon F, Depaula JR, Meyers D, Detera-Wadleigh S, Goldin LR, Gershon ES, Blehar MC, Nurnberger JI. Initial genomic scan of the NIMH genetics initiative bipolar pedigrees: chromosomes 3,5,15,16,17,and 22, Am J Med Genet 1997;74:238-46.
  • Radhakrishna U, Senol S, Herken H, Gucuyener K, Gehrig C, Blouin JL, Akarsu NA, Antonarakis SE. An apparently dominant bipolar affectice disorders locus on chromosome 20p11.2-q11.2 in a large Turkish pedigree, Eur J Hum Genet, 2001;9:39-44.
  • Herken H. Depresyonun etyolojisinde genetik kanıtlar. Klinik Psikiyatri Dergisi, Ek sayı 2002;4:5-10.
  • O’Donovan M, Jones I, Craddock N. Anticipation and repeat expansion in bipolar disorder Am J Med Genet C Semin Med Genet. 2003;15;123:10-7.
  • McMahon FJ, Stine OC, Meyers DA, Simpson SG, DePaulo JR. Patterns of maternal transmission in bipolar affective disorder. Am J Hum Genet, 1995;56:1277-86.
  • Borglum AD, Kirov G, Craddock N, Mors O, Muir W, Murray V, McKee I, Collier DA, Ewald H, Owen MJ, Blackwood D, Kruse TA. Possible parentof-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder. Am J Med Genet B Neuropsychiatr Genet, 2003;117:18-22.
  • Seifuddin F, Mahon PB, Judy J, Pirooznia M, Jancic D, Taylor J, Goes FS, Potash JB, Zandi PP. Meta-Analysis of Genetic Association Studies on Bipolar Disorder. Am J Med Genet Part B 2012.159B:508-518.
  • Meltzer H: Serotonergic dysfunction in depression. Br J Psychiatry Suppl 1989; 8:25-31.
  • Lucas JJ, Hen R: New players in the 5-HT receptor field: genes and knockouts. Trends Pharmacol Sci 1995; 16:246-252.
  • Gershon ES, Martinez M, Goldin LR, Gejman PV: Genetic mapping of common diseases: the challenges of manic-depressive, illness and schizophrenia. Trends Genet 1990; 6: 282-287.
  • Gutierrez B, Arranz M, Fananas L, Valles V, Guillamat R, van Os J, Collier D. 5HT2A receptor gene and bipolar affective, disorder (letter). Lancet 1995; 346:9
  • Gutierrez B, Fananas L, Arranz M, Valles V, Guillamat R, van Os J, Collier D: Allelic association analysis of the 5HT2C receptor gene in bipolar affective disorder. Neurosci Lett 1996; 212:65-67.
  • Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CAD. Polymorphism in serotonin transporter, gene associated with susceptibility to major depression. Lancet 1996; 347:731-733.
  • Bellivier F, Leboyer M, Courtet P, Buresi C, Beaufils B, Samolyk D, Allilaire JF, Feingold J, Mallet J, Malafosse A: Association, between the tryptophan hydroxylase gene and manic-depressive illness. Arch Gen Psychiatry 1998; 55:33-37.
  • Angela Heiden, Petra Schüssler, Ulrike Itzlinger, Friedrich Leisch, Joachim Scharfetter, Christian Gebhardt, Karoline Fuchs, Matthäus Willeit, Linda Nilsson, Ellenore Miller-Reiter, Thomas Stompe, Kurt Meszaros, Werner Sieghart, Kurt Hornik, Siegfried Kasper, Harald N. Aschauer, Association Studies of Candidate Genes in Bipolar Disorders Neuropsychobiology 2000;42:18-21.
  • Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996; 6: 243–250.
  • Syvanen A-C, Tilgmann C, Rinne J, Ulmanen I. Genetic polymorphism of catechol-O-methyltransferase (COMT): correlation of genotype with individual variation of S-COMT activity and comparison of the allele frequencies in the normal population and Parkinsonian patients in Finland. Pharmacogenetics 1997; 7: 65-71.
  • Lachman HM, Morrow B, Shprintzen R, Veit S, Parsia SS, Faedda G, Goldberg R, Kucherlapati R, Papolos DF. Association of codon 108/158 catechol-Omethyltransferase gene polymorphism with the psychiatric manifestations of velo-cardiofacial syndrome. Am J Med Genet 1996; 67:468-472.
  • Kirov G, Murphy KC, Arranz MJ, Jones I, McCandles F, Kunugi H Murray RM, McGuffin P, Collier DA, Owen MJ, Craddock N. Low activity allele of catechol-O-methyltransferase gene associated with rapid cycling bipolar disorder. Mol Psychiatry 1998; 3: 342–345.
  • Papolos DR, Veit S, Faedda GL, Saito T, Lachman HM. Ultra-ultra rapid cycling bipolar disorder is associated with the low activity catecholamineO-methyltransferase allele. Mol Psychiatry 1998; 3:346–349.
  • Strouss R, Bark N, Volavka J, Parsia SS, Lachman HM. Association of COMT codon 158 polymorphism aggressive and antisocial behavior in schizophrenia. Psychiatr Res 1997; 69: 71–77.
  • Lachman HM, Nolan K, Mohr P, Saito T, Volavka J. Association between COMT genotype and violence in schizophrenia and schizoaffective disorder. Am J Psychiatry 1998; 155: 835–837.
  • Karayiorgou M, Altemus M, Galke BL, Goldman D, Murphy DL, Ott J Gogos JA. Genotype determining low catechol-O-methyltransferase act as a risk factor for obsessive-compulsive disorder. Proc Natl Acad Sci USA 1997; 94: 4571–4575.
  • Ohara K, Nagai M, Suzuki Y. Low activity allele of catechol-O-methyltransferase gene and Japanese unipolar depression, Neuroreport, 1998;11;9:1305-8.
  • Savas HA, Erdal ME, Yumru M, Ozen ME, Herken H. İki uçlu bozuklukta katekol-O-metil trasnferaz enzim geni polimorfizimi: cinsiyetin etkisi, 41. Ulusal psikiyatri kognresi 1-5 Eylül 2005.
  • Qian W, Homma M, Itagaki F, Tachikawa H, Kawanishi Y, Mizukami K, Asada T, Inomata S, Honda K, Ohkohchi N, Kohda Y. MDR1 gene polymorphism in Japanese patients with schizophrenia and mood disorders including depression. Biol Pharm Bull. 2006;29:2446-50.
  • Turgut G, Kurt E, Sengul C, Alatas G, Kursunluoglu R, Oral T, Turgut S, Herken H. Association of MDR1 C3435T polymorphism with bipolar mdisorder in patients treated with valporic acid, Mol Biol Rep. 2009;36:495-9.
  • Barrett TB, Emberton JE, Nievergelt CM, Liang SG, Hauger RL, Eskin E, Schork NJ, Kelsoe JR. Further evidence for association of GRK3 to bipolar disorder suggests a second disease mutation. Psychiatr Genet. 2007;17:315-22.
  • Cataloluk O, Nacak M. Savas HA, Tutkun H, Zoroglu SS, Herken H, Barlas Ö, Arslan A. Angiotesin Converting Enzyme Gene In Turkish Bipolar Affective Disorders Patients. Psychiatry, Neurology and Brain Research, 2003;10:129-132.
  • Özen ME, Erdal ME, Savaş HA, Yumru M, Herken H. İki uçlu bozuklukta cinsiyetler arası genetik bir farklılık: Triptofan hidroksilaz polimorfizmi. Poster bildiri. 41. Ulusal Psikiyatri Kongresi 15-20 Kasım Palandöken Erzurum 2005.
  • Mundo E, Walker M, Cate T, Macciardi F, Kennedy JL. The role of serotonin transporter protein gene in antidepressant-induced mania in bipolar disorder: preliminary findings.Arch Gen Psychiatry 2001;58:539-44.
  • Craddock N, O’Donovan MC, Owen MJ. Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology.Schizophr Bull. 2006;32:9-16.
  • Breen G, Prata D, Osborne S, Munro J, Li T, Staddon S, Sainz D, Kerwin R, St. Clair D, Collier D. Association of the Dysbindin Gene With Bipolar Affective Disorder, Am J Psychiatry 2006; 163:1636-1638.
  • Green EK, Raybould R, Macgregor S, Gordon-Smith K, Heron J, Hyde S, Grozeva D, Hamshere M, Williams N, Owen MJ, O’Donovan MC, Jones L, Jones I, Kirov G, Craddock N. Operation of the Schizophrenia Susceptibility Gene, Neuregulin 1, Across Traditional Diagnostic Boundaries to Increase Risk for Bipolar Disorder, Arch Gen Psychiatry. 2005;62:642-648.
  • Blackwood DH, Fordyce A, Walker MT, St Clair DM, Porteous DJ, Muir WJ. Schizophrenia and affective disorders-cosegregation with a translocation at chromosome 1q42 that directly disrupts brain-expressed genes: clinical and P300 findings in a family. Am J Hum Genet. 2001;69:428-433.
  • Ekelund J, Hovatta I, Parker A, Paunio T, Varilo T, Martin R, Suhonen J, Ellonen P, Chan G, Sinsheimer JS, Sobel E, Juvonen H, Arajärvi R, Partonen T, Suvisaari J, Lönnqvist J, Meyer J, Peltonen L. Chromosome 1 loci in Finnish schizophrenia families. Hum. Mol. Genet. 2001;10:1611–1617.
  • Ekelund J, Hennah W, Hiekkalinna T, Parker A, Meyer J, Lönnqvist J, Peltonen L. Replication of 1q42 linkage in Finnish schizophrenia pedigrees. Mol Psychiatry. 2004;9:1037-41.
  • Macgregor S, Visscher PM, Knott SA, Thomson P, Porteous DJ, Millar JK, Devon RS, Blackwood D, Muir WJ. A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42. Mol Psychiatry. 2004; 9:1083–1090.
  • Hamshere ML, Bennett P, Williams N, Segurado R, Cardno A, Norton N, Lambert D, Williams H, Kirov G, Corvin A, Holmans P, Jones L, Jones I, Gill M, O’Donovan MC, Owen MJ, Craddock N. Genome-wide linkage scan in schizoaffective disorder: Significant evidence for linkage (LOD=3.54) at 1q42 close to DISC1, and suggestive evidence at 22q11 and 19q13. Archives of General Psychiatry. 2005;62:1081–1088.
  • Sklar P, Gabriel SB, McInnis MG, et al. Family-based association study of 76 candidate genes in bipolar disorder: BDNF is a potential risk locus. Brain-derived neutrophic factor. Mol Psychiatry. 2002;7:579–593.
  • Neves-Pereira M, Mundo E, Muglia P, King N, Macciardi F, Kennedy JL. The brainderived neurotrophic factor gene confers susceptibility to bipolar disorder: evidence from a family-based association study. Am J Hum Genet. 2002;71:651–655.
  • Geller B, Badner JA, Tillman R, et al. Linkage disequilibrium of the brainderived neurotrophic factor Val66Met polymorphism in children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry. 2004;161:1698–1700.
  • Demiryurek S, Savas HA, Igci M, Herken H, Gorucu S, Kara AF, Selek S, Oguzkan S, Bulbul F, Arslan A, Demiryurek AT. Association between the 196G > A (VAL66 MET) and -1360C > T (C-270T) polymorphisms of the brain-derived neurotrophic factor gene and bipolar disorder. Neurology
  • Psychıatry and Brain Research. 2006;13:125-130.
  • Green EK, Raybould R, Macgregor S, Hyde S, Young AH, O’Donovan MC, Owen MJ, Kirov G, Jones L, Jones I, Craddock N. Genetic variation at brain-derived neurotrophic factor (BDNF) is associated with rapid cycling in aUKbipolar disorder case-control sample of over 3000 individuals. Br J Psychiatry. 2006;188:21-5.
  • Neves-Pereira M, Cheung JK, Pasdar A, Zhang F, Breen G, Yates P, Sinclair M, Crombie C, Walker N, St Clair DM. BDNF gene is a risk factor for schizophrenia in a Scottish population. Mol Psychiatry. 2005;10:208–212.
  • Schumacher J, Jamra RA, Becker T, Ohlraun S, Klopp N, Binder EB, Schulze TG, Deschner M, Schmäl C, Höfels S, Zobel A, Illig T, Propping P, Holsboer F, Rietschel M, Nöthen MM, Cichon S. Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depression. Biol Psychiatry. 2005;58:307–314.
  • Szekeres G, Juhasz A, Rimanoczy A, Keri S, Janka Z. The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia. Schizophr Res, 2003;65:15-18.
  • Treutlein J, Rietschel M. Genome-wide association studies of alcohol dependence and substance use disorders. Curr Psychiatry Rep. 2011;13:147-55.
  • Sklar P, Ripke S, Scott LJ, Andreassen OA, Cichon S, Craddock N, Edenberg HJ, Nurnberger JI Jr, Rietschel M, Blackwood D, Corvin A, Flickinger M, Guan W, Mattingsdal M, McQuillin A, Kwan P, Wienker TF, Daly M, Dudbridge F, Holmans PA, Lin D, Burmeister M, Greenwood TA, Hamshere ML, Muglia P, Smith EN, Zandi PP, Nievergelt CM, McKinney R, Shilling PD, Schork NJ, Bloss CS, Foroud T, Koller DL, Gershon ES, Liu C, Badner JA, Scheftner WA, Lawson WB, Nwulia EA, Hipolito M, Coryell W, Rice J, Byerley W, McMahon FJ, Schulze TG, Berrettini W, Lohoff FW, Potash JB, Mahon PB, McInnis MG, Zöllner S, Zhang P, Craig DW, Szelinger S, Barrett TB, Breuer R, Meier S, Strohmaier J, Witt SH, Tozzi F, Farmer A, McGuffin P, Strauss J, Xu W, Kennedy JL, Vincent JB, Matthews K, Day R, Ferreira MA, O’Dushlaine C, Perlis R, Raychaudhuri S, Ruderfer D, Hyoun PL, Smoller JW, Li J, Absher D, Thompson RC, Meng FG, Schatzberg AF, Bunney WE, Barchas JD, Jones EG, Watson SJ, Myers RM, Akil H, Boehnke M, Chambert K, Moran J, Scolnick E, Djurovic S, Melle I, Morken G, Gill M, Morris D, Quinn E, Mühleisen TW, Degenhardt FA, Mattheisen M, Schumacher J, Maier W, Steffens M, Propping P, Nöthen MM, Anjorin A, Bass N, Gurling H, Kandaswamy R, Lawrence J, McGhee K, McIntosh A, McLean AW, Muir WJ, Pickard BS, Breen G, St Clair D, Caesar S, Gordon-Smith K, Jones L, Fraser C, Green EK, Grozeva D, Jones IR, Kirov G, Moskvina V, Nikolov I, O’Donovan MC, Owen MJ, Collier DA, Elkin A, Williamson R, Young AH, Ferrier IN, Stefansson K, Stefansson H, Thornorgeirsson T, Steinberg S, Gustafsson O, Bergen SE, Nimgaonkar V, Hultman C, Landén M, Lichtenstein P, Sullivan P, Schalling M, Osby U, Backlund L, Frisén L, Langstrom N, Jamain S, Leboyer M, Etain B, Bellivier F, Petursson H, Sigur Sson E, Müller-Mysok B, Lucae S, Schwarz M, Schofield PR, Martin N, Montgomery GW, Lathrop M, Oskarsson H, Bauer M, Wright A, Mitchell PB, Hautzinger M, Reif A, Kelsoe JR, Purcell SM. Psychiatric GWAS Consortium Bipolar Disorder Working Group. Largescale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. Nat Genet. 2011;43:977-83. doi: 1038/ng.943.
  • Campos-de-Sousa S, Guindalini C, Tondo L, et al. Nuclear receptor reverb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder. J Biol Rhythms 2010; 25:132–137.
  • Szczepankiewicz A, Skibinska M, Suwalska A, et al. No association of three GRIN2B polymorphisms with lithium response in bipolar patients. Pharmacol Rep 2009; 61:448–452.
  • Perlis RH, Adams DH, Fijal B, et al. Genetic association study of treatment response with olanzapine/fluoxetine combination or lamotrigine in bipolar I depression. J Clin Psychiatry 2010; 71:599–605.
Toplam 62 adet kaynakça vardır.

Ayrıntılar

Birincil Dil Türkçe
Bölüm Makaleler
Yazarlar

Hasan Herken Bu kişi benim

Yayımlanma Tarihi 1 Mayıs 2013
Yayımlandığı Sayı Yıl 2013 Cilt: 3 Sayı: 5

Kaynak Göster

APA Herken, H. (2013). İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular. Journal of Mood Disorders, 3(5).
AMA Herken H. İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular. Journal of Mood Disorders. Mayıs 2013;3(5).
Chicago Herken, Hasan. “İki uçlu Bozukluk Tanı Ve Tedavisine ilişkin Genetik Bulgular”. Journal of Mood Disorders 3, sy. 5 (Mayıs 2013).
EndNote Herken H (01 Mayıs 2013) İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular. Journal of Mood Disorders 3 5
IEEE H. Herken, “İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular”, Journal of Mood Disorders, c. 3, sy. 5, 2013.
ISNAD Herken, Hasan. “İki uçlu Bozukluk Tanı Ve Tedavisine ilişkin Genetik Bulgular”. Journal of Mood Disorders 3/5 (Mayıs 2013).
JAMA Herken H. İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular. Journal of Mood Disorders. 2013;3.
MLA Herken, Hasan. “İki uçlu Bozukluk Tanı Ve Tedavisine ilişkin Genetik Bulgular”. Journal of Mood Disorders, c. 3, sy. 5, 2013.
Vancouver Herken H. İki uçlu bozukluk tanı ve tedavisine ilişkin genetik bulgular. Journal of Mood Disorders. 2013;3(5).