Abnormal Expression of miRNA in Women with Polycystic Ovary Syndrome (PCOS)

Yıl 2023, , 183 - 191, 19.10.2023

Sude Topkaraoğlu , Gulam Hekimoğlu

https://doi.org/10.55517/mrr.1324616

Cited By: 1

Öz

Polycystic ovary syndrome (PCOS) is a debilitating endocrine and metabolic disorder that affects a large proportion of women in their reproductive years. It differs by a range of symptoms including polycystic ovary appearance, hyperandrogenism, chronic anovulation, insulin resistance, and obesity. Despite years of research, the exact cause of PCOS remains elusive, but recent studies have suggested that epigenetic mechanisms may play a significant role in its pathogenesis. Of particular interest are micro-RNAs (miRNAs), short non-coding RNAs that are transcribed from DNA but not translated into protein. Recent research has demonstrated that abnormal expression of miRNAs is present in PCOS and may contribute to the development and progression of the disease. This review aims to provide an in-depth analysis of the current knowledge and challenges related to abnormal miRNA expression in PCOS, shedding light on a potential avenue for targeted therapies and improved management of this debilitating condition. The review summarizes the findings from various studies that have investigated the role of miRNAs in PCOS. It discusses the specific miRNAs that have been found to be dysregulated in PCOS and their potential impact on the pathophysiology of the disease. The review also highlights the challenges associated with studying miRNAs, including the complexity of their regulation and the need for standardized methodologies for miRNA profiling. Based on the available evidence, abnormal expression of miRNAs appears to be a significant contributor to the development and progression of PCOS. Targeting these dysregulated miRNAs could offer new therapeutic strategies for the management of PCOS. Biomarkers and gene therapies associated with miRNA may improve the accuracy and effectiveness of PCOS diagnosis and treatment. However, further research is needed to fully understand the functional roles of specific miRNAs and their potential as diagnostic or therapeutic targets.

Anahtar Kelimeler

Biomarker, Epigenetic, Infertility, miRNA, PCOS

Polikistik Over Sendromlu (PKOS) Kadınlarda Anormal MiRNA Ekspresyonu

Öz

Polikistik over sendromu (PCOS), üreme çağındaki kadınların büyük bir kısmını etkileyen, zorlayıcı bir endokrin ve metabolik bozukluktur. Polikistik over görünümü, hiperandrojenizm, kronik anovulasyon, insülin direnci ve obezite gibi bir dizi belirtiyle kendini gösterir. Yıllar süren araştırmalara rağmen, PCOS'nin kesin nedeni hala belirsizdir, ancak son çalışmalar epigenetik mekanizmaların patogenezinde önemli bir rol oynayabileceğini öne sürmüştür. Özellikle mikroRNA'lar (miRNA'lar) ilgi çekicidir, DNA'dan transkript edilen ancak proteinlere çevrilmeyen kısa kodlamayan RNA'lardır. Son araştırmalar, miRNA'ların PCOS'da anormal ifadesinin bulunduğunu ve hastalığın gelişimine ve ilerlemesine katkıda bulunabileceğini göstermiştir. Bu derleme, PCOS'da anormal miRNA ifadesi ile ilgili mevcut bilginin ve zorlukların ayrıntılı bir analizini sunmayı amaçlamaktadır. Bu durumun hedefe yönelik tedavilere ve geliştirilmiş yönetim stratejilerine yönelik potansiyel bir yolunu aydınlatmaktadır. Derleme, miRNA'ların PCOS'daki rolünü araştıran çeşitli çalışmaların bulgularını özetlemektedir. PCOS'da disregüle olduğu bulunan belirli miRNA'ları ve hastalığın patofizyolojisine olan potansiyel etkilerini tartışmaktadır. Derleme ayrıca miRNA'ların incelenmesiyle ilişkili zorlukları vurgulamakta, bunların düzenlemesinin karmaşıklığını ve miRNA profilleme için standartlaştırılmış metodolojilere olan ihtiyacı ele almaktadır. Mevcut kanıtlara dayanarak, miRNA'ların anormal ifadesinin PCOS'nin gelişimine ve ilerlemesine önemli bir katkı sağladığı görülmektedir. Bu disregüle miRNA'ların hedef alınması, PCOS'nin yönetimi için yeni tedavi stratejileri sunabilir. miRNA ile ilişkili biyobelirteçler ve gen terapileri, PKOS tanı ve tedavisinin doğruluğunu ve etkinliğini artırabilir. Bununla birlikte, belirli miRNA'ların işlevsel rollerini ve tanısal veya terapötik hedef olarak potansiyellerini tam olarak anlamak için daha fazla araştırmaya ihtiyaç vardır. Sonuç olarak, bu derleme PCOS'daki miRNA'ların rolüne dair değerli içgörüler sunmakta ve gelecekteki araştırma ve tedavi yaklaşımları için umut verici bir yol belirlemektedir.

Anahtar Kelimeler

Biyobelirteç, Epigenetik, Kısırlık, miRNA, PKOS

Kaynakça

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