Obez ve Normal Ağırlıktaki Bireylerde Diyete Benzer Miktarda Arjinin Takviyesinin Fraksiyonel Ekshale Nitrik Oksit (FeNO) Düzeyleri Üzerindeki Etkileri

Öz

Amaç: Daha önce yapılan çalışmalarda arjinin-nitrik oksit yolağı obezite gibi bazı kronik hastalıklara özgü yolaklar ile ilişkilendirilmiştir. Bu çalışmanın amacı, obez ve normal ağırlıktaki bireylerde diyete benzer miktarda arjinin takviyesinin fraksiyonel ekshale nitrik oksit (FeNO) düzeyleri üzerindeki etkilerini incelemektir. Yöntem: Bu çalışma 40 katılımcı (20 obez ve 20 kontrol) ile gerçekleştirilmiştir. Katılımcılar bir gecelik açlığın ardından 4500 mg arjinin takviyesi ve düşük proteinli (41 mg arjinin/25 g toz ürün) çorba tüketmiştir. Dinlenme metabolizma hızı (DMH) ve 1., 2. ve 5. saat FeNO düzeyleri ölçülmüş ve 3 günlük besin tüketimleri kaydedilmiştir. Bulgular: Obez gruptaki katılımcıların ortalama başlangıç ve 1. saat FeNO düzeyi ile kontrol grubundaki katılımcıların ortalama başlangıç FeNO düzeyi arasında anlamlı bir fark yoktu. Kontrol grubundaki katılımcıların ortalama 2. ve 5. saat FeNO düzeyleri, obez gruptaki katılımcıların ortalama 2. ve 5. saat FeNO düzeylerinden anlamlı olarak daha yüksekti (p<0.05). Sonuç: Normal ağırlıktaki katılımcıların obez katılımcılardan daha yüksek FeNO düzeylerine sahip olması, muhtemelen hava yolu inflamasyonu ve obezite arasındaki ilişkiye işaret eden önceki çalışmaları desteklemektedir.

Anahtar Kelimeler

• Arjinin
• Obezite
• Solunum
• Nitrik oksit
• Vücut ağırlığı

Effects of Dietary-Like Amount of Arginine Supplementation on Fractional Exhaled Nitric Oxide (FeNO) Levels in Obese and Normal-Weight Individuals

Öz

Aim: In previous studies, the arginine-nitric oxide pathway has been associated with pathways specific to some chronic diseases such as obesity. The purpose of this study was to examine the effects of dietary-like amounts of arginine supplementation on fractional exhaled nitric oxide (FeNO) levels in obese and normal-weighted individuals. Methods: This study was conducted with 40 participants (20 obese and 20 control). The participants consumed 4500 mg arginine supplement and low protein (41 mg arginine/25 g powder product) soup after one-night hunger. Resting metabolic rate (RMR) and 1st, 2nd, and 5th hour fractional exhaled nitric oxide (FeNO) levels were measured and 3-day food consumptions were recorded. Results: There was no significant difference between the mean baseline and 1st -hour FeNO level of the participants in the obese group and the mean baseline FeNO level of the participants in the control group. The mean 2nd and 5th hour FeNO level of the participants in the control group were significantly higher than the mean 2nd and 5th hour FeNO levels of the participants in the obese group (p<0.05). Conclusion: The fact that normal-weighted participants had higher FeNO levels than obese participants probably support previous studies that pointed to the relationship between airway inflammation and obesity.

Anahtar Kelimeler

• Arginine
• Obesity
• Respiration
• Nitric oxide
• Body weight

Kaynakça

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