Bağışıklık Sisteminin Bekçileri Makrofajların Gizemli Dünyası

Yıl 2025, Cilt: 8 Sayı: 2, 127 - 139, 30.06.2025

Kübra Başol Baki , Mukaddes Eşrefoğlu

https://doi.org/10.55517/mrr.1630658

Öz

Mononükleer fagositik sistemin önemli elemanları olan makrofajlar vücudun savunma mekanizmalarının sürdürülmesi için önemlidirler. Güçlü fagositik aktiviteleri ve verimli antijen sunumlarıyla tanınan bu çok yönlü hücreler, etkilerini bağışıklığın ötesine taşıyarak doku gelişimi, onarımı ve homeostazisinde önemli roller oynarlar. Oldukça heterojen bir grup olan makrofajlar, farklı dokuların özel ihtiyaçlarına uyum sağlayarak çeşitli organlarda farklı isimler alırlar. İki ana fenotipe ayrılabilirler: klasik olarak aktive edilmiş (pro-inflamatuar) makrofajlar ve alternatif olarak aktive edilmiş (anti-inflamatuar) makrofajlar. Makrofaj polarizasyonunu kontrol ederek inflamatuar yanıtları düzenlemek makrofajlarla bağlantılı birçok hastalığın engellenmesinde ve tedavisinde etkili olabilir. Bu derlemede makrofajların kökenleri, mikroskobik ve fonksiyonel özellikleri, tipleri, işaretleme yöntemleri ve klinik önemleri ele alınmıştır.

Anahtar Kelimeler

fenotip , inflamasyon , Makrofaj

Etik Beyan

Bir derleme çalışması olduğundan etik kurul onayı gerekmemiştir.

Destekleyen Kurum

Yazarlar, bu makalenin araştırılması ve/veya yazarlığı için herhangi bir finansal destek almamıştır.

The Mysterious World of Macrophages, the Guardians of the Immune System

Öz

Macrophages, key players of the mononuclear phagocytic system, are essential for maintaining the body’s defense mechanisms. Renowned for their robust phagocytic activity and efficient antigen presentation, these versatile cells extend their influence beyond immunity, playing pivotal roles in tissue development, repair, and homeostasis. As a highly heterogeneous group, macrophages adapt to the specific needs of different tissues, earning distinct names across various organs. They can polarize into two major phenotypes: classically activated (pro-inflammatory) macrophages and alternatively activated (anti-inflammatory) macrophages. Regulating inflammatory responses by controlling macrophage polarization may be effective in preventing and treating many diseases associated with macrophages. In this review, the origins, microscopic and functional properties, types, labeling methods and clinical importance of macrophages are discussed.

Anahtar Kelimeler

phenotype , inflammation , Macrophages

Kaynakça

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