Effects of oleic acid

Öz

Content of fatty diet plays a significant role in the development and progression of chronic diseases. Generally, it is accepted that unsaturated fatty acids are beneficial. According to literature review, oleic acid (C18:1n-9) has positive impacts on various tissues in general and has negative impacts rarely. Olive oil composition includes high amount oleic acid. Considering of the effects of oleic acid on the cardiovascular system, it was determined that decreasing of the myocardial infarction rate, platelet aggregation and secretion of TXA2, plus reduce of the systolic blood pressure. LDL cholesterol was decreased. In terms of effects on the liver, while some studies suggest that oleic acid has beneficial effects, unlike other studies proved that exposed to oleic acid of hepatocytes induce ER (endoplasmic reticulum) stress in long - term period. The several studies which were investigating the efficacy of the oleic acid on the tumor tissue proved that OA increased to hepato-tumorigenesis in vivo as a potential. On te other hand, another research showed that oleic acid blocked the action of HER-2 / neu oncogene that led to breast cancer. Although some researchers reported that OA develop neutrophil phagocytic capacity and candidacidal activity, other researchers point out that these fatty acids didn’t cause any changes on bactericidal activity and fatty acids caused moderate decreases on phagocytosis and chemotaxis only in extremely high concentrations, and they suppressed to T lymphocytes. Although, most of studies have indicated to beneficial effects of oleic acids, also the adverse effects of oleic acid have been reported in a few studies. This situation requires further researches for detail information about oleic acid

Anahtar Kelimeler

• Oleic acid, Cancer, Liver, Immune system, Cardiovascular system disease

Effects of oleic acid

Öz

Kaynakça

1. 1. Montgomery R, Conway TW, Spector A. Approach with biochemistry Case Reports. Palme Publishing. 2000;6:297
2. 2. Poudyal H, Kumar SA, Iyer A, Waanders J, Ward LC, Brown L. Responses to oleic, linoleic and alphalinolenic acids in high-carbohydrate, high-fat dietinduced metabolic syndrome in rats. The Journal of nutritional biochemistry. 2013;24(7):1381-92.
3. 3. Cocchi M, Tonello L, Martínez ÁJ, Lercker G, Caramia GM. Extra virgin olive oil and oleic acid. Nutr. clín. diet. hosp. 2009;29(3):12-24
4. 4. Tunstall-Pedoe H, Kuulasmaa K, Mahonen M, Tolonen H, Ruokokoski E, Amouyel P. Contribution of trends in survival and coronary-event rates to changes in coronary heart disease mortality: 10-year results from 37 WHO MONICA project populations. Monitoring trends and determinants in cardiovascular disease. Lancet. 1999;353(9164):1547-57. 5. Masia R, Pena A, Marrugat J, Sala J, Vila J, Pavesi M,
5. et al. High prevalence of cardiovascular risk factors in Gerona, Spain, a province with low myocardial infarction incidence. REGICOR Investigators. Journal of epidemiology and community health. 1998;52(11):707-15.
6. 6. Covas MI. Olive oil and the cardiovascular system. Pharmacological research : the official journal of the Italian Pharmacological Society. 2007;55(3):175-86.
7. 7. US Food and Drug Administration. Press Release November 1. http://www.fda.gov/bbs/topics/news/2004/NEW01129.h tlm (last access: October 28, 2006). 2004;P04-100.
8. 8. Kris-Etherton PM, Mustad V, Derr JA. Effects of dietary stearic acid on plasma lipids and thrombosis. Nutr. Today. 1993;28: 30-38

9. 9. Nunez D, Randon J, Gandhi C, Siafaka-Kapadai A, Olson MS, Hanahan DJ. The inhibition of plateletactivating factor-induced platelet activation by oleic acid is associated with a decrease in polyphosphoinositide metabolism. The Journal of biological chemistry. 1990;265(30):18330-8.
10. 10. Barradas MA, Christofides JA, Jeremy JY, Mikhailidis DP, Fry DE, Dandona P,et al. The Effect of Olive Oil Supplementation on Human Platelet Function, Serum Cholesterol-Related Variables and Plasma Fibrinogen Concentrations. A Pilot Study, Nutrition Research. 1990;10:403-411
11. 11. Teres S, Barcelo-Coblijn G, Benet M, Alvarez R, Bressani R, Halver JE, et al. Oleic acid content is responsible for the reduction in blood pressure induced by olive oil. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(37):13811-6.
12. 12. Claudia DF, Thierry C, Pooja K, Guenter H (2012). Absence of Adipose Triglyceride Lipase Protects From Hepatic Endoplasmic Reticulum Stress in Mice; Hepatology; 56:270-280
13. 13. Fuchs CD, Claudel T, Kumari P, Haemmerle G, Pollheimer MJ, Stojakovic T, et al. Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice. Hepatology. 2012;56(1):270- 80.
14. 14. Caviglia JM, Gayet C, Ota T, Hernandez-Ono A, Conlon DM, Jiang H, et al. Different fatty acids inhibit apoB100 secretion by different pathways: unique roles for ER stress, ceramide, and autophagy. Journal of lipid research. 2011;52(9):1636-51.
15. 15. Dixon JL, Furukawa S, Ginsberg HN. Oleate stimulates secretion of apolipoprotein B-containing lipoproteins from Hep G2 cells by inhibiting early intracellular degradation of apolipoprotein B. The Journal of biological chemistry. 1991;266(8):5080-6.
16. 16. Rutledge AC, Su Q, Adeli K. Apolipoprotein B100 biogenesis: a complex array of intracellular mechanisms regulating folding, stability, and lipoprotein assembly. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2010;88(2):251-67.
17. 17. Ota T, Gayet C, Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. The Journal of clinical investigation. 2008;118(1):316-32.
18. 18. Pan M, Maitin V, Parathath S, Andreo U, Lin SX, St Germain C, et al. Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control. Proceedings of the National Academy of Sciences of the United States of America. 2008;105(15):5862-7.
19. 19. Qiu W, Zhang J, Dekker MJ, Wang H, Huang J, Brumell JH, et al. Hepatic autophagy mediates endoplasmic reticulum stress-induced degradation of misfolded apolipoprotein B. Hepatology. 2011;53(5):1515-25.
20. 20. Wu HT, Chen W, Cheng KC, Ku PM, Yeh CH, Cheng JT. Oleic acid activates peroxisome proliferatoractivated receptor delta to compensate insulin resistance in steatotic cells. The Journal of nutritional biochemistry. 2012;23(10):1264-70.
21. 21. Karaçor K, Çam M, Orhan N, Coşgun E, Demirin H. High Fatty Diet Effects on Rat Liver European Journal Gen Medical. 2014;11(2): 99-108
22. 22. Kudo Y, Tanaka Y, Tateishi K, Yamamoto K, Yamamoto S, Mohri D, et al. Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway. Journal of hepatology. 2011;55(6):1400-8.
23. 23. David TW. Oleic Acid – The Anti-Breast Cancer Component in Olive Oil. AU J.T. 2005;9(2):75-78
24. 24. Mendez JA, Vellon L, Colomer R,Lupu R (2005). Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (HerceptinTM) in breast cancer cells with Her-2/neu oncogene amplification. European Society for Medical Oncology
25. 25. Menendez JA, Vellon L, Colomer R, Lupu R. Oleic acid, the main monounsaturated fatty acid of olive oil, suppresses Her-2/neu (erbB-2) expression and synergistically enhances the growth inhibitory effects of trastuzumab (Herceptin) in breast cancer cells with Her- 2/neu oncogene amplification. Annals of oncology : official journal of the European Society for Medical Oncology / ESMO. 2005;16(3):359-71.
26. 26. Carrillo C, Cavia Mdel M, Alonso-Torre S. Role of oleic acid in immune system; mechanism of action; a review. Nutricion hospitalaria. 2012;27(4):978-90.
27. 27. Carluccio MA, Massaro M, Bonfrate C, Siculella L, Maffia M, Nicolardi G, et al. Oleic acid inhibits endothelial activation : A direct vascular antiatherogenic mechanism of a nutritional component in the mediterranean diet. Arteriosclerosis, thrombosis, and vascular biology. 1999;19(2):220-8..
28. 28. Massaro M, Carluccio MA, De Caterina R. Direct vascular antiatherogenic effects of oleic acid: a clue to the cardioprotective effects of the Mediterranean diet. Cardiologia. 1999;44(6):507-13.
29. 29. Sanadgol N, Mostafaie A, Bahrami G, Mansouri K, Ghanbari F, Bidmeshkipour A. Elaidic acid sustains LPS and TNF-alpha induced ICAM-1 and VCAM-I expression on human bone marrow endothelial cells (HBMEC). Clinical biochemistry. 2010;43(12):968-72.
30. 30. Christon RA. Mechanisms of action of dietary fatty acids in regulating the activation of vascular endothelial cells during atherogenesis. Nutrition reviews. 2003;61(8):272-9.
31. 31. De Caterina R, Libby P. Control of endothelial leukocyte adhesion molecules by fatty acids. Lipids. 1996;31 Suppl:S57-63.
32. 32. Holthe MR, Andersson Y, Lyberg T. Lack of proinflammatory effects of free fatty acids on human umbilical cord vein endothelial cells and leukocytes. Acta obstetricia et gynecologica Scandinavica. 2005;84(7):672-8.
33. 33. Harvey KA, Walker CL, Xu Z, Whitley P, Pavlina TM, Hise M, et al. Oleic acid inhibits stearic acid-induced inhibition of cell growth and pro-inflammatory responses in human aortic endothelial cells. Journal of lipid research. 2010;51(12):3470-80.
34. 34. Mastrangelo AM, Jeitner TM, Eaton JW. Oleic acid increases cell surface expression and activity of CD11b on human neutrophils. Journal of immunology. 1998;161(8):4268-75.
35. 35. Ferrante A, Goh D, Harvey DP, Robinson BS, Hii CS, Bates EJ, et al. Neutrophil migration inhibitory properties of polyunsaturated fatty acids. The role of fatty acid structure, metabolism, and possible second messenger systems. The Journal of clinical investigation. 1994;93(3):1063-70.
36. 36. Padovese R, Curi R. Modulation of rat neutrophil function in vitro by cis- and trans-MUFA. The British journal of nutrition. 2009;101(9):1351-9.
37. 37. Martins de Lima-Salgado T, Coccuzzo Sampaio S, Cury-Boaventura MF, Curi R. Modulatory effect of fatty acids on fungicidal activity, respiratory burst and TNF-alpha and IL-6 production in J774 murine macrophages. The British journal of nutrition. 2011;105(8):1173-9.
38. 38. Hawley HP, Gordon GB. The effects of long chain free fatty acids on human neutrophil function and structure. Laboratory investigation; a journal of technical methods and pathology. 1976;34(2):216-22.
39. 39. Badwey JA, Curnutte JT, Karnovsky ML. cisPolyunsaturated fatty acids induce high levels of superoxide production by human neutrophils. The Journal of biological chemistry. 1981;256(24):12640-3.
40. 40. Badwey JA, Curnutte JT, Robinson JM, Berde CB, Karnovsky MJ, Karnovsky ML. Effects of free fatty acids on release of superoxide and on change of shape by human neutrophils. Reversibility by albumin. The Journal of biological chemistry. 1984;259(12):7870-7.
41. 41. Morimoto YM, Sato E, Nobori K, Takahashi R, Utsumi K. Effect of calcium ion on fatty acid-induced generation of superoxide in guinea pig neutrophils. Cell structure and function. 1986;11(2):143-55.
42. 42. Hatanaka E, Levada-Pires AC, Pithon-Curi TC, Curi R. Systematic study on ROS production induced by oleic, linoleic, and gamma-linolenic acids in human and rat neutrophils. Free radical biology & medicine. 2006;41(7):1124-32.
43. 43. Yamaguchi T, Kaneda M, Kakinuma K. Effect of saturated and unsaturated fatty acids on the oxidative metabolism of human neutrophils. The role of calcium ion in the extracellular medium. Biochimica et biophysica acta. 1986;861(3):440-6.
44. 44. Li Y, Ferrante A, Poulos A, Harvey DP. Neutrophil oxygen radical generation. Synergistic responses to tumor necrosis factor and mono/polyunsaturated fatty acids. The Journal of clinical investigation. 1996;97(7):1605-9.
45. 45. Hardy SJ, Robinson BS, Ferrante A, Hii CS, Johnson DW, Poulos A, et al. Polyenoic very-long-chain fatty acids mobilize intracellular calcium from a thapsigargin-insensitive pool in human neutrophils. The relationship between Ca2+ mobilization and superoxide production induced by long- and very-long-chain fatty acids. The Biochemical journal. 1995;311 ( Pt 2):689- 97.
46. 46. Juttner B, Kroplin J, Coldewey SM, Witt L, Osthaus WA, Weilbach C, et al. Unsaturated long-chain fatty acids induce the respiratory burst of human neutrophils and monocytes in whole blood. Nutrition & metabolism. 2008;5:19.
47. 47. Hwang TL, Su YC, Chang HL, Leu YL, Chung PJ, Kuo LM, et al. Suppression of superoxide anion and elastase release by C18 unsaturated fatty acids in human neutrophils. Journal of lipid research. 2009;50(7):1395- 408.
48. 48. Tanaka T, Makino R, Iizuka T, Ishimura Y, Kanegasaki S. Activation by saturated and monounsaturated fatty acids of the O2- -generating system in a cell-free preparation from neutrophils. The Journal of biological chemistry. 1988;263(27):13670-6.
49. 49. Chow SC, Jondal M. Polyunsaturated free fatty acids stimulate an increase in cytosolic Ca2+ by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in T cells through a mechanism independent of phosphoinositide turnover. The Journal of biological chemistry. 1990;265(2):902-7.
50. 50. Chow SC, Ansotegui IJ, Jondal M. Inhibition of receptor-mediated calcium influx in T cells by unsaturated non-esterified fatty acids. The Biochemical journal. 1990;267(3):727-32.
51. 51. Randriamampita C, Trautmann A. Arachidonic acid activates Ca2+ extrusion in macrophages. The Journal of biological chemistry. 1990;265(30):18059-62.
52. 52. Breittmayer JP, Pelassy C, Cousin JL, Bernard A, Aussel C. The inhibition by fatty acids of receptormediated calcium movements in Jurkat T-cells is due to increased calcium extrusion. The Journal of biological chemistry. 1993;268(28):20812-7.
53. 53. Carrillo C, del Mar Cavia M, Alonso-Torre SR. Oleic acid versus linoleic and alpha-linolenic acid. different effects on Ca2+ signaling in rat thymocytes. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011;27(3-4):373-80.
54. 54. Carrillo C, Del Mar Cavia M, Roelofs H, Wanten G, Alonso-Torre SR. Activation of human neutrophils by oleic acid involves the production of reactive oxygen species and a rise in cytosolic calcium concentration: a comparison with N-6 polyunsaturated fatty acids. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2011;28(2):329-38.
55. 55. Hidalgo MA, Nahuelpan C, Manosalva C, Jara E, Carretta MD, Conejeros I, et al. Oleic acid induces intracellular calcium mobilization, MAPK phosphorylation, superoxide production and granule release in bovine neutrophils. Biochemical and biophysical research communications. 2011;409(2):280-6.
56. 56. Verlengia R, Gorjao R, Kanunfre CC, Bordin S, de Lima TM, Curi R. Effect of arachidonic acid on proliferation, cytokines production and pleiotropic genes expression in Jurkat cells--a comparison with oleic acid. Life sciences. 2003;73(23):2939-51.
57. 57. Llado V, Gutierrez A, Martinez J, Casas J, Teres S, Higuera M, et al. Minerval induces apoptosis in Jurkat and other cancer cells. Journal of cellular and molecular medicine. 2010;14(3):659-70.
58. 58. Yaqoob P, Newsholme EA, Calder PC. The effect of dietary lipid manipulation on rat lymphocyte subsets and proliferation. Immunology. 1994;82(4):603-10.
59. 59. Yaqoob P, Newsholme EA, Calder PC. The effect of fatty acids on leukocyte subsets and proliferation in whole blood. Nutr Res. 1995;15:279-87.
60. 60. Calder PC, Costa-Rosa LF, Curi R. Effects of feeding lipids of different fatty acid compositions upon rat lymphocyte proliferation. Life sciences. 1995;56(6):455-63.
61. 61. Jeffery NM, Yaqoob P, Newsholme EA, Calder PC. The effects of olive oil upon rat serum lipid levels and lymphocyte functions appear to be due to oleic acid. Annals of nutrition & metabolism. 1996;40(2):71-80.
62. 62. Jeffery NM, Cortina M, Newsholme EA, Calder PC. Effects of variations in the proportions of saturated, monounsaturated and polyunsaturated fatty acids in the rat diet on spleen lymphocyte functions. The British journal of nutrition. 1997;77(5):805-23.
63. 63. Cury-Boaventura MF, Pompeia C, Curi R. Comparative toxicity of oleic acid and linoleic acid on Jurkat cells. Clinical nutrition. 2004;23(4):721-32.
64. 64. Cury-Boaventura MF, Pompeia C, Curi R. Comparative toxicity of oleic acid and linoleic acid on Raji cells. Nutrition. 2005;21(3):395-405.