“Nephrotic Syndrome Associated with Breast Cancer; When should it be treated?

Öz

We hereby describe a 46-year woman with nephrotic syndrome and new-onset breast cancer. This patient admitted to our hospital with peripheral edema and a mass in her right breast. Membranous glomerulonephritis (MGN) was the etiology of nephrotic syndrome. MGN has been reported in association with a wide variety of solid neoplastic diseases, although rarely occurs as a complication of breast carcinoma. We report a rare and a resistant case of MGN, who was concomitant diagnosed with breast cancer and there was no improvement in proteinuria although breast cancer was under-controlled with cheomotheraphy and surgery. 

Anahtar Kelimeler

• breast cancer; proteinuria; treatment

Kaynakça

1. Valcamonico F, Ferrari V, Simoncini E, Gregorini G, Vassalli L, Amoroso V., et al. Paraneoplastic Nephrotic Syndrome in Advanced Breast Cancer Patient. A Case Report. Tumori 2004; 90 (1): 154-156.
2. Eagen JW, Lewis EJ. Glomerulopathies of neoplasia. Kidney Int 1977; 11:297-306.
3. Pai P, Bone JM, McDicken I, Bell GM. Solid tumour and glomerulopathy. Q J Med 1996; 89:361-367.
4. Ozawa T, Pluss R, Lacher J, Boadecker E, Guggenheim S, Hammond W., et al. Endogenous immune complex nephropathy associated with malignancy: studies on the nature and immunopathogenic significance of glomerular bound antigen and antibody, isolation and characterisation of tumour specific antigen and antibody and circulating immune complexes. Q J Med 1975; 44:523-541.
5. Gagliano RG, Costanzi JJ, Beathard GA, Sarles HE, Bell JD. The Nephrotic Syndrome Associated with Neoplasia: An Unusual Paraneoplastic Syndrome Report of a Case and Review of the Literature. Am J Med 1976; 60:1026-1031.