Pregnancy outcome of a case with Swyer syndrome after bilateral gonadectomy and adjuvant chemotherapy

Yıl 2016, Cilt: 3 Sayı: 7, 286 - 9, 15.07.2016

Cenk Gezer , Atalay Ekin , Alkim Gulsah Sahingoz Ulas Solmaz , Tugba Karadeniz Sevil Sayhan Mehmet Ozeren

https://doi.org/10.17546/msd.80958

Öz

Swyer syndrome is a rare disorder characterized by a phenotypic female with an XY karyotype. We presented a patient with Swyer syndrome with a diagnosis of malign germ cell tumor. After bilateral gonadectomy and pelvic lymph node dissection, the patient received four courses of bleomycin, etoposide and cisplatin chemotherapy. The patient was free from tumour recurrence after 13years’ follow-up. A successful pregnancy was achieved by oocyte donation and in vitro fertilization. Caesarean delivery was performed at 37 gestational weeks due to oligohydramnios and intrauterine growth restriction.

Anahtar Kelimeler

46 , XY gonadal dysgenesis , chemotherapy; gonadectomy; pregnancy; Swyer syndrome

Kaynakça

• Swyer GI. Male pseudohermaphroditism: a hitherto undescribed form. British medical journal. 1955 Sep 17;2(4941):709-12. PubMed PMID: 13250193. PMCID: 1980764.
• Chen MJ, Yang JH, Mao TL, Ho HN, Yang YS. Successful pregnancy in a gonadectomized woman with 46,XY gonadal dysgenesis and gonadoblastoma. Fertility and sterility. 2005 Jul;84(1):217. PubMed PMID: 16009184.
• Frydman R, Parneix I, Fries N, Testart J, Raymond JP, Bouchard P. Pregnancy in a 46, XY patient. Fertility and sterility. 1988 Nov;50(5):813-4. PubMed PMID: 3181493.
• Hughes IA, Houk C, Ahmed SF, Lee PA, Group LC, Group EC. Consensus statement on management of intersex disorders. Archives of disease in childhood. 2006 Jul;91(7):554-63. PubMed PMID: 16624884. PMCID: 2082839.
• Michala L, Goswami D, Creighton SM, Conway GS. Swyer syndrome: presentation and outcomes. BJOG : an international journal of obstetrics and gynaecology. 2008 May;115(6):737-41. PubMed PMID: 18410658.
• Dirnfeld M, Bider D, Abramovicia H, Calderon I, Blumenfeld Z. Subsequent successful pregnancy and delivery after intracytoplasmic sperm injection in a patient with XY gonadal dysgenesisms. European journal of obstetrics, gynecology, and reproductive biology. 2000 Jan;88(1):101-2. PubMed PMID: 10659926.
• Creatsas G, Deligeoroglou E, Tsimaris P, Pantos K, Kreatsa M. Successful pregnancy in a Swyer syndrome patient with preexisting hypertension. Fertility and sterility. 2011 Aug;96(2):e83-5. PubMed PMID: 21782051.
• Kan AK, Abdalla HI, Oskarsson T. Two successful pregnancies in a 46,XY patient. Human reproduction. 1997 Jul;12(7):1434-5. PubMed PMID: 9262272.
• Sauer MV, Lobo RA, Paulson RJ. Successful twin pregnancy after embryo donation to a patient with XY gonadal dysgenesis. American journal of obstetrics and gynecology. 1989 Aug;161(2):380-1. PubMed PMID: 2764056.
• Ko PC, Peng HH, Soong YK, Chang SD. Triplet pregnancy complicated with one hydatidiform mole and preeclampsia in a 46,XY female with gonadal dysgenesis. Taiwanese journal of obstetrics & gynecology. 2007 Sep;46(3):276-80. PubMed PMID: 17962110.
• Tulic I, Tulic L, Micic J. Pregnancy in patient with Swyer syndrome. Fertility and sterility. 2011 Apr;95(5):1789 e1-2. PubMed PMID: 21195397.
• Fedder J, Ørskov M, Rubeck PK. Pregnancies in XY women: Is a weak myometrium cause of complications during pregnancy and delivery? . Asian Pac J Reprod 2013;2(1):76-9.
• Siddique H, Daggett P, Artley K. Successful term vaginal delivery in a 46,XY woman. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2008 Jun;101(3):298-9. PubMed PMID: 18280476.
• Practice Committee of the American Society for Reproductive M. Increased maternal cardiovascular mortality associated with pregnancy in women with Turner syndrome. Fertility and sterility. 2006 Nov;86(5 Suppl 1):S127-8. PubMed PMID: 17055808.
• Herrmann T, Thiede G, Trott KR, Voigtmann L. [Offsprings of preconceptionally irradiated parents. Final report of a longitudinal study 1976-1994 and recommendations for patients' advisory]. Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft [et al]. 2004 Jan;180(1):21-30. PubMed PMID: 14704841. Nachkommen prakonzeptionell bestrahlter Eltern. Abschlussbericht einer Longitudinalstudie 1976-1994 und Empfehlungen zur Patientenberatung.