A case of primary malignant melanoma of the larynx

Yıl 2019, , 59 - 62, 30.03.2019

Özge Kaya , Dudu Solakoğlu Kahraman , Gülden Diniz , Gönül Demir

https://doi.org/10.17546/msd.500996

Öz

Objective:  Malignant melanoma of the larynx is an uncommon tumor type that can be seen as a primary tumor or as a metastasis from a cutaneous primary lesion.  Morphological appearances of this tumor are readily confused with the other types of laryngeal cancers.  A new case of primary laryngeal malignant melanoma has been presented in this case report . Case: The patient was a 54-year-old man without any clinical evidence of other cutaneous malignant melanocytic lesions. Microscopically, polygonal-epithelioid tumor cells containing cytoplasmic and nuclear melanin were located under the mucosal squamous epithelial cells. Atypical mitotic figures were also present. Ulceration and disruption of the epithelium weren’t observed. Immunohistochemical studies were positive for S100, HMB-45, Melan-A and vimentin while it was negative for cytokeratin. Based on findings this diagnosis was established.

Anahtar Kelimeler

Mucosal malignant melanoma, laryngeal primary melanoma, malignant melanoma

Kaynakça

• 1. Wenig BM. Laryngeal mucosal malignant melanoma: a clinicopathologic,immunohistochemical, and ultrastructural study of four patients and a review of the literature. Cancer. 1995;75:1568-1577
• 2. Cojocaru O, Aşchie M, Mocanu L, Baltatescu GI. Laryngeal primary malignant melanoma: a case report.Rom J MorpholEmbryol 2015, 56(4):1513-1516
• 3. Amin HH, Petruzzeli GJ, Huain AN, Nickoloff BJ. Primary malignant melanoma of the larynx. Arch Pathol Lab Med,2001,125:271-273.
• 4. El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ. World Health Organization Classification of Head and Neck Tumours. 4th ed. Lyon: IARC; 2017. pp. 60–61. 126-127.
• 5. Terada T, Saeki N, Toh K, Uwa N, Sagawa K, Mouri T, Sakagami M. Primary malignantmelanoma of the larynx:a case report and litareture review. AurisNasus Larynx, 2007, 34(1):105-110.
• 6. Zaghi S, Pouldar D, Lai C, Chettri DK. Subglottic presentation of a rare tumor:primary or metastatic? Primary mucosal melanoma of the subglottic larynx. JAMA Otolaryngol Head Neck Surg,2013,139(7):739-740.
• 7. Lohia S, Boersma I, Lentsch E. Primary malignant melanoma of the larynx- A case report. Otolaryngology Case Reports 4 (2017) 15-17.