Öz
Congenital afibrinogenemia is a rare bleeding disorder. It may be manifested as umblical, mucosal, intramuscular, intraarticular, or life-threatening intracranial bleeding. A third-day-old infant was admitted for umblical cord bleeding, and was found to have a prolonged prothrobin time [PT], and activated partial thromboplastin time [aPTT], and a very low fibrinogen level. He was diagnosed as congenital afibrinogenemia, and reported for the rarity of disease, and discussion of novel therapeutic approaches
Anahtar Kelimeler
Congenital afibrinogenemia umblical cord bleeding fibrinogen concentrate
Kaynakça
- Conflict of Interest
- The authors declared that they had no
- anaesthesiology. 2008;25(6):519-21. European journal of 14.
- Cronin C, Fitzpatrick D, Temperley I. Multiple pulmonary
- emboli in a patient with afibrinogenaemia. Acta
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- De Mattia D, Regina G, Giordano P, Del Vecchio GC,
- Altomare M, Schettini F. Association of congenital
- afibrinogenemia and K-dependent protein C deficiency--a
- case report. Angiology. 1993;44(9):745-9. 16. de Moerloose P, Neerman-Arbez M. Congenital fibrinogen disorders. Seminars in thrombosis and hemostasis. 2009;35(4):356-66. 17. Peyvandi F, Haertel S, Knaub S, Mannucci PM. Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypofibrinogenemia. Journal of thrombosis and haemostasis : JTH. 2006;4(7):1634-7. 18.
- Parameswaran R, Dickinson JP, de Lord S, Keeling DM,
- Colvin BT. Spontaneous intracranial bleeding in two
- patients with congenital afibrinogenaemia and the role of
- replacement therapy. Haemophilia : the official journal of
- the World Federation of Hemophilia. 2000;6(6):705-8.
- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Öz
Kaynakça
- Conflict of Interest
- The authors declared that they had no
- anaesthesiology. 2008;25(6):519-21. European journal of 14.
- Cronin C, Fitzpatrick D, Temperley I. Multiple pulmonary
- emboli in a patient with afibrinogenaemia. Acta
- haematologica. 1988;79(1):53-4. 15.
- De Mattia D, Regina G, Giordano P, Del Vecchio GC,
- Altomare M, Schettini F. Association of congenital
- afibrinogenemia and K-dependent protein C deficiency--a
- case report. Angiology. 1993;44(9):745-9. 16. de Moerloose P, Neerman-Arbez M. Congenital fibrinogen disorders. Seminars in thrombosis and hemostasis. 2009;35(4):356-66. 17. Peyvandi F, Haertel S, Knaub S, Mannucci PM. Incidence of bleeding symptoms in 100 patients with inherited afibrinogenemia or hypofibrinogenemia. Journal of thrombosis and haemostasis : JTH. 2006;4(7):1634-7. 18.
- Parameswaran R, Dickinson JP, de Lord S, Keeling DM,
- Colvin BT. Spontaneous intracranial bleeding in two
- patients with congenital afibrinogenaemia and the role of
- replacement therapy. Haemophilia : the official journal of
- the World Federation of Hemophilia. 2000;6(6):705-8.
- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Vaka Sunumu |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Mart 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 1 Sayı: 1 |
