BibTex RIS Kaynak Göster

Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L.

Yıl 2014, Cilt: 1 Sayı: 2, 51 - 60, 01.06.2014
https://doi.org/10.17546/msd.43365

Öz

Objective: Diabetes mellitus (DM) is a group of metabolic diseases with high blood glucose, which cause the damage and dysfunction of some of the organ systems. Although various oral drugs are used to treat DM, they do not prevent the development of DM related diseases such as nephropathy and retinopathy and glucose dependent vascular diseases. Thus novel strategies for the prevention and treatment of DM are urgently needed. This research aimed to reveal the effects of Thymus Vulgaris Lamiaceae (TVL) and Thymbra Spicata Lamiaceae (TSL) on the damaging effects of DM. Methods: P repared TVL and TSL aqueous extracts were studied in the streptozocin induced experimental diabetic rat model. Blood glucose, body weight, and blood biochemical alterations were measured. Rat kidney for nephropathy were enucleated and fixed in paraffin blocks to examine histopathological changes. Results: Briefly, impaired blood glucose, and weight loss of Diabetic rats were significantly improved by TVL in dose dependent manner (P<0.01). Impaired Blood Uric acid, Urea, and liver enzymes were significantly improved and adjusted to the control group values (P<0.001). The histological analyses of the kidney in TVL and TSL groups revealed the findings of significant healing properties, which was similar to the normal structures of kidney. Conclusions: In this study, strong biochemical, physiological, and histological improvements in the DM related disorders, such as neuropathy and nephropathy were obtained by TVL treatment.

Kaynakça

  • Increased risk of renal deterioration associated with low e
  • GFR in type 2 diabetes mellitus only in albuminuric
  • subjects. Internal medicine. 2009;48(9):657-63. 19.
  • Zhu WW, Chen HP, Ge YC, Xie HL, Zeng CH, Li LS, et
  • al. Ultrastructural changes in the glomerular filtration
  • barrier and occurrence of proteinuria in Chinese patients
  • with type 2 diabetic nephropathy. Diabetes research and
  • clinical practice. 2009;86(3):199-207. 20.
  • Abdel-Rahman EM, Saadulla L, Reeves WB, Awad AS.
  • Therapeutic modalities in diabetic nephropathy: standard
  • and emerging approaches. Journal of general internal
  • medicine. 2012;27(4):458-68. 21.
  • Reddy MA, Tak Park J, Natarajan R. Epigenetic
  • modifications in the pathogenesis of diabetic nephropathy.
  • Seminars in nephrology. 2013;33(4):341-53. 22.
  • Brenner BM, Hostetter TH, Humes HD. Glomerular
  • permselectivity: barrier function based on discrimination
  • of molecular size and charge. The American journal of
  • physiology. 1978;234(6):F455-60. 23.
  • Varghese SA, Powell TB, Budisavljevic MN, Oates JC,
  • Raymond JR, Almeida JS, et al. Urine biomarkers predict
  • the cause of glomerular disease. Journal of the American
  • Society of Nephrology : JASN. 2007;18(3):913-22. 24.
  • Najafian B, Mauer M. Progression of diabetic
  • nephropathy in type 1 diabetic patients. Diabetes research
  • and clinical practice. 2009;83(1):1-8. 25.
  • Suzuki D, Miyazaki M, Jinde K, Koji T, Yagame M,
  • Endoh M, et al. In situ hybridization studies of matrix
  • metalloproteinase-3, tissue inhibitor of metalloproteinase
  • 1 and type IV collagen in diabetic nephropathy. Kidney
  • international. 1997;52(1):111-9.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.

Impairments of Diabetes Mellitus related Nephropathy and blood bio- chemicals by the Thymus Vulgaris L. and Thymbra Spicata L

Yıl 2014, Cilt: 1 Sayı: 2, 51 - 60, 01.06.2014
https://doi.org/10.17546/msd.43365

Öz

Kaynakça

  • Increased risk of renal deterioration associated with low e
  • GFR in type 2 diabetes mellitus only in albuminuric
  • subjects. Internal medicine. 2009;48(9):657-63. 19.
  • Zhu WW, Chen HP, Ge YC, Xie HL, Zeng CH, Li LS, et
  • al. Ultrastructural changes in the glomerular filtration
  • barrier and occurrence of proteinuria in Chinese patients
  • with type 2 diabetic nephropathy. Diabetes research and
  • clinical practice. 2009;86(3):199-207. 20.
  • Abdel-Rahman EM, Saadulla L, Reeves WB, Awad AS.
  • Therapeutic modalities in diabetic nephropathy: standard
  • and emerging approaches. Journal of general internal
  • medicine. 2012;27(4):458-68. 21.
  • Reddy MA, Tak Park J, Natarajan R. Epigenetic
  • modifications in the pathogenesis of diabetic nephropathy.
  • Seminars in nephrology. 2013;33(4):341-53. 22.
  • Brenner BM, Hostetter TH, Humes HD. Glomerular
  • permselectivity: barrier function based on discrimination
  • of molecular size and charge. The American journal of
  • physiology. 1978;234(6):F455-60. 23.
  • Varghese SA, Powell TB, Budisavljevic MN, Oates JC,
  • Raymond JR, Almeida JS, et al. Urine biomarkers predict
  • the cause of glomerular disease. Journal of the American
  • Society of Nephrology : JASN. 2007;18(3):913-22. 24.
  • Najafian B, Mauer M. Progression of diabetic
  • nephropathy in type 1 diabetic patients. Diabetes research
  • and clinical practice. 2009;83(1):1-8. 25.
  • Suzuki D, Miyazaki M, Jinde K, Koji T, Yagame M,
  • Endoh M, et al. In situ hybridization studies of matrix
  • metalloproteinase-3, tissue inhibitor of metalloproteinase
  • 1 and type IV collagen in diabetic nephropathy. Kidney
  • international. 1997;52(1):111-9.
  • Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
  • License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
  • provided the original work is properly cited.
Toplam 34 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Araştırma Makalesi
Yazarlar

Zafer Akan Bu kişi benim

Melek Dikilidal Bu kişi benim

Hulya Ozdemir Bu kişi benim

Gokhan Oto Bu kişi benim

Mehmet Bilgehan Yuksel Bu kişi benim

Salaheddin Akcay Bu kişi benim

Seda Vatansever Bu kişi benim

Hayrunnisa Yesil Bu kişi benim

Ahmet Yilmaz Bu kişi benim

Ahmet Var Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2014
Yayımlandığı Sayı Yıl 2014 Cilt: 1 Sayı: 2

Kaynak Göster

APA Akan, Z., Dikilidal, M., Ozdemir, H., Oto, G., vd. (2014). Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L. Medical Science and Discovery, 1(2), 51-60. https://doi.org/10.17546/msd.43365
AMA Akan Z, Dikilidal M, Ozdemir H, Oto G, Yuksel MB, Akcay S, Vatansever S, Yesil H, Yilmaz A, Var A. Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L. Med Sci Discov. Haziran 2014;1(2):51-60. doi:10.17546/msd.43365
Chicago Akan, Zafer, Melek Dikilidal, Hulya Ozdemir, Gokhan Oto, Mehmet Bilgehan Yuksel, Salaheddin Akcay, Seda Vatansever, Hayrunnisa Yesil, Ahmet Yilmaz, ve Ahmet Var. “ And Thymbra Spicata L”. Medical Science and Discovery 1, sy. 2 (Haziran 2014): 51-60. https://doi.org/10.17546/msd.43365.
EndNote Akan Z, Dikilidal M, Ozdemir H, Oto G, Yuksel MB, Akcay S, Vatansever S, Yesil H, Yilmaz A, Var A (01 Haziran 2014) Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L. Medical Science and Discovery 1 2 51–60.
IEEE Z. Akan, “ and Thymbra Spicata L”., Med Sci Discov, c. 1, sy. 2, ss. 51–60, 2014, doi: 10.17546/msd.43365.
ISNAD Akan, Zafer vd. “ And Thymbra Spicata L”. Medical Science and Discovery 1/2 (Haziran 2014), 51-60. https://doi.org/10.17546/msd.43365.
JAMA Akan Z, Dikilidal M, Ozdemir H, Oto G, Yuksel MB, Akcay S, Vatansever S, Yesil H, Yilmaz A, Var A. Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L. Med Sci Discov. 2014;1:51–60.
MLA Akan, Zafer vd. “ And Thymbra Spicata L”. Medical Science and Discovery, c. 1, sy. 2, 2014, ss. 51-60, doi:10.17546/msd.43365.
Vancouver Akan Z, Dikilidal M, Ozdemir H, Oto G, Yuksel MB, Akcay S, Vatansever S, Yesil H, Yilmaz A, Var A. Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L. Med Sci Discov. 2014;1(2):51-60.

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