Impairments of Diabetes Mellitus related Nephropathy and blood bio-chemicals by the Thymus Vulgaris L. and Thymbra Spicata L.
Öz
Objective: Diabetes mellitus (DM) is a group of metabolic diseases with high blood glucose, which cause the damage and dysfunction of some of the organ systems. Although various oral drugs are used to treat DM, they do not prevent the development of DM related diseases such as nephropathy and retinopathy and glucose dependent vascular diseases. Thus novel strategies for the prevention and treatment of DM are urgently needed. This research aimed to reveal the effects of Thymus Vulgaris Lamiaceae (TVL) and Thymbra Spicata Lamiaceae (TSL) on the damaging effects of DM. Methods: P repared TVL and TSL aqueous extracts were studied in the streptozocin induced experimental diabetic rat model. Blood glucose, body weight, and blood biochemical alterations were measured. Rat kidney for nephropathy were enucleated and fixed in paraffin blocks to examine histopathological changes. Results: Briefly, impaired blood glucose, and weight loss of Diabetic rats were significantly improved by TVL in dose dependent manner (P<0.01). Impaired Blood Uric acid, Urea, and liver enzymes were significantly improved and adjusted to the control group values (P<0.001). The histological analyses of the kidney in TVL and TSL groups revealed the findings of significant healing properties, which was similar to the normal structures of kidney. Conclusions: In this study, strong biochemical, physiological, and histological improvements in the DM related disorders, such as neuropathy and nephropathy were obtained by TVL treatment.
Anahtar Kelimeler
Diabetes mellitus Streptozocin Diabetic rat Thymus Vulgaris L. Thymbra Spicata L. AST ALT UREA Nephyropathy Nephyron
Kaynakça
- Increased risk of renal deterioration associated with low e
- GFR in type 2 diabetes mellitus only in albuminuric
- subjects. Internal medicine. 2009;48(9):657-63. 19.
- Zhu WW, Chen HP, Ge YC, Xie HL, Zeng CH, Li LS, et
- al. Ultrastructural changes in the glomerular filtration
- barrier and occurrence of proteinuria in Chinese patients
- with type 2 diabetic nephropathy. Diabetes research and
- clinical practice. 2009;86(3):199-207. 20.
- Abdel-Rahman EM, Saadulla L, Reeves WB, Awad AS.
- Therapeutic modalities in diabetic nephropathy: standard
- and emerging approaches. Journal of general internal
- medicine. 2012;27(4):458-68. 21.
- Reddy MA, Tak Park J, Natarajan R. Epigenetic
- modifications in the pathogenesis of diabetic nephropathy.
- Seminars in nephrology. 2013;33(4):341-53. 22.
- Brenner BM, Hostetter TH, Humes HD. Glomerular
- permselectivity: barrier function based on discrimination
- of molecular size and charge. The American journal of
- physiology. 1978;234(6):F455-60. 23.
- Varghese SA, Powell TB, Budisavljevic MN, Oates JC,
- Raymond JR, Almeida JS, et al. Urine biomarkers predict
- the cause of glomerular disease. Journal of the American
- Society of Nephrology : JASN. 2007;18(3):913-22. 24.
- Najafian B, Mauer M. Progression of diabetic
- nephropathy in type 1 diabetic patients. Diabetes research
- and clinical practice. 2009;83(1):1-8. 25.
- Suzuki D, Miyazaki M, Jinde K, Koji T, Yagame M,
- Endoh M, et al. In situ hybridization studies of matrix
- metalloproteinase-3, tissue inhibitor of metalloproteinase
- 1 and type IV collagen in diabetic nephropathy. Kidney
- international. 1997;52(1):111-9.
- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Impairments of Diabetes Mellitus related Nephropathy and blood bio- chemicals by the Thymus Vulgaris L. and Thymbra Spicata L
Öz
Kaynakça
- Increased risk of renal deterioration associated with low e
- GFR in type 2 diabetes mellitus only in albuminuric
- subjects. Internal medicine. 2009;48(9):657-63. 19.
- Zhu WW, Chen HP, Ge YC, Xie HL, Zeng CH, Li LS, et
- al. Ultrastructural changes in the glomerular filtration
- barrier and occurrence of proteinuria in Chinese patients
- with type 2 diabetic nephropathy. Diabetes research and
- clinical practice. 2009;86(3):199-207. 20.
- Abdel-Rahman EM, Saadulla L, Reeves WB, Awad AS.
- Therapeutic modalities in diabetic nephropathy: standard
- and emerging approaches. Journal of general internal
- medicine. 2012;27(4):458-68. 21.
- Reddy MA, Tak Park J, Natarajan R. Epigenetic
- modifications in the pathogenesis of diabetic nephropathy.
- Seminars in nephrology. 2013;33(4):341-53. 22.
- Brenner BM, Hostetter TH, Humes HD. Glomerular
- permselectivity: barrier function based on discrimination
- of molecular size and charge. The American journal of
- physiology. 1978;234(6):F455-60. 23.
- Varghese SA, Powell TB, Budisavljevic MN, Oates JC,
- Raymond JR, Almeida JS, et al. Urine biomarkers predict
- the cause of glomerular disease. Journal of the American
- Society of Nephrology : JASN. 2007;18(3):913-22. 24.
- Najafian B, Mauer M. Progression of diabetic
- nephropathy in type 1 diabetic patients. Diabetes research
- and clinical practice. 2009;83(1):1-8. 25.
- Suzuki D, Miyazaki M, Jinde K, Koji T, Yagame M,
- Endoh M, et al. In situ hybridization studies of matrix
- metalloproteinase-3, tissue inhibitor of metalloproteinase
- 1 and type IV collagen in diabetic nephropathy. Kidney
- international. 1997;52(1):111-9.
- Copyright © 2014 The Author(s); This is an open-access article distributed under the terms of the Creative Commons Attribution
- License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium,
- provided the original work is properly cited.
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Araştırma Makalesi |
| Yazarlar | |
| Yayımlanma Tarihi | 1 Haziran 2014 |
| Yayımlandığı Sayı | Yıl 2014 Cilt: 1 Sayı: 2 |
